Page last updated: 2024-12-05

monolinuron

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Monolinuron is a phenylurea herbicide, a derivative of diuron, that is used to control weeds in a variety of crops, including sugar beet, potatoes, and soybeans. It is a selective herbicide, meaning that it kills weeds but not the crop plants. Monolinuron works by inhibiting photosynthesis in weeds, specifically by blocking the electron transport chain in photosystem II. The compound is absorbed through the roots and leaves of weeds. It is generally applied as a pre-emergent herbicide, before weeds have a chance to germinate. Monolinuron is a persistent herbicide, meaning that it can remain active in the soil for an extended period of time. Its persistence can be beneficial for long-term weed control, but it also means that it can be a source of groundwater contamination. The use of monolinuron has been restricted in some countries due to its environmental effects. It is often studied because it is an effective herbicide that can be used to control a variety of weeds, but its environmental persistence and potential for groundwater contamination are also a concern. Monolinuron is synthesized by the reaction of 3-(4-chlorophenyl)-1,1-dimethylurea with 2-chloro-4-nitroaniline. The compound has been shown to be effective in controlling a variety of weeds, including annual grasses, broadleaf weeds, and sedges. It is also being studied for its potential to control aquatic weeds. Monolinuron is a relatively expensive herbicide, but it is effective and can provide long-term weed control.'

monolinuron: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15629
CHEMBL ID1320234
CHEBI ID81965
SCHEMBL ID65568
MeSH IDM0096771

Synonyms (60)

Synonym
SDCCGMLS-0013702.P002
urea, 3-(p-chlorophenyl)-1-methoxy-1-methyl-
urea, n'-(4-chlorophenyl)-n-methoxy-n-methyl-
n'-(4-chlorophenyl)-n-methoxy-n-methylurea
smr000069097
MLS000058831
monorotox
caswell no. 207d
hsdb 5030
arezin
monolinuron [bsi:iso]
3-(p-chlorophenyl)-1-methoxy-1-methylurea
aresin
n-(4-chlorophenyl)-n'-methoxy-n-methylurea
hoe 02747
epa pesticide chemical code 207500
premalin
hoe 2747
3-(4-chlorophenyl)-1-methoxy-1-methylurea
einecs 217-129-5
monolinuron
arezine
3-(4-chlorphenyl)-1-methoxy-1-methylharnstoff [german]
brn 2212523
AKOS001686898
C18794
1746-81-2
3-(4-chlorphenyl)-1-methoxy-1-methylharnstoff
6kjj4xad6m ,
unii-6kjj4xad6m
cas-1746-81-2
dtxsid0037576 ,
tox21_301360
dtxcid8017576
NCGC00255518-01
HMS2402C08
S10380
monolinuron [iso]
monolinuron [mi]
monolinuron [hsdb]
SCHEMBL65568
CHEBI:81965 ,
1-methoxy-1-methyl-3-(4-chlorophenyl)urea
LKJPSUCKSLORMF-UHFFFAOYSA-N
afesin
arresin
CHEMBL1320234
1-(4-chlorophenyl)-3-methoxy-3-methylurea
monolinuron, pestanal(r), analytical standard
monolinuron 100 microg/ml in acetonitrile
monolinuron 10 microg/ml in acetonitrile
J-011027
M3269
BCP05312
mfcd00055264
DS-16467
Q6901670
AMY10726
A924734
CS-0151364
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
ureas
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (15)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
TDP1 proteinHomo sapiens (human)Potency16.36010.000811.382244.6684AID686979
GLI family zinc finger 3Homo sapiens (human)Potency0.24340.000714.592883.7951AID1259369
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency47.64370.001022.650876.6163AID1224838; AID1224893
progesterone receptorHomo sapiens (human)Potency0.96890.000417.946075.1148AID1346795
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency11.22020.28189.721235.4813AID2326
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency44.70700.003041.611522,387.1992AID1159552; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency24.33650.001530.607315,848.9004AID1224849
pregnane X nuclear receptorHomo sapiens (human)Potency48.55770.005428.02631,258.9301AID1346982
aryl hydrocarbon receptorHomo sapiens (human)Potency28.39520.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency34.37620.001723.839378.1014AID743083
histone deacetylase 9 isoform 3Homo sapiens (human)Potency32.93840.037617.082361.1927AID1259364; AID1259388
pyruvate kinase PKM isoform aHomo sapiens (human)Potency1.58490.04017.459031.6228AID1631; AID1634
ras-related protein Rab-9AHomo sapiens (human)Potency0.89130.00022.621531.4954AID485297
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.00000.050127.073689.1251AID588590
Guanine nucleotide-binding protein GHomo sapiens (human)Potency12.58931.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (23.81)18.7374
1990's4 (19.05)18.2507
2000's3 (14.29)29.6817
2010's7 (33.33)24.3611
2020's2 (9.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.37 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.52 (4.65)
Search Engine Demand Index44.85 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (26.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies3 (14.29%)4.05%
Observational0 (0.00%)0.25%
Other17 (80.95%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]