Compounds > eremanthin
Page last updated: 2024-12-07

eremanthin

Eremanthin is a natural compound isolated from the roots of the plant *Eremophila mitchellii*. It has been shown to have potential anti-inflammatory and antioxidant properties. Its biosynthesis is thought to involve the shikimate pathway, leading to the production of a phenylpropanoid precursor. Further studies are investigating its potential as a therapeutic agent for conditions such as arthritis and neurodegenerative diseases. The unique structure and biological activities of eremanthin make it a subject of ongoing research.'

Cross-References

ID SourceID
PubMed CID100572
CHEMBL ID451364
CHEBI ID4815
SCHEMBL ID9516039
MeSH IDM0043271

Synonyms (15)

Synonym
NCI60_002782
azuleno[4, 3a,4,6a,7,8,9,9a,9b-octahydro-6-methyl-3,9-bis(methylene)-, [3as-(3a.alpha.,6a.alpha.,9a.alpha.,9b.beta.)]-
nsc-321215
NSC321215 ,
C09406
eremanthin
37936-58-6
(3as,6ar,9ar,9bs)-6-methyl-3,9-dimethylidene-4,6a,7,8,9a,9b-hexahydro-3ah-azuleno[4,5-b]furan-2-one
chebi:4815 ,
CHEMBL451364
nsc 321215
azuleno(4,5-b)furan-2(3h)-one, 3a,4,6a,7,8,9,9a,9b-octahydro-6-methyl-3,9-bis(methylene)-, (3as-(3aalpha,6aalpha,9aalpha,9bbeta))-
SCHEMBL9516039
DTXSID50191371
Q27106489

Research Excerpts

Overview

Eremanthin is a potent anticancer agent against human cervical cancer. It may be included as lead molecule in cervical cancer treatment provided further in vitro and in vivo investigations are performed.

ExcerptReferenceRelevance
"Eremanthin molecule is a potent anticancer agent against human cervical cancer and may be included as lead molecule in cervical cancer treatment provided further in vitro and in vivo investigations are performed."( Anticancer activity of Eremanthin against the human cervical cancer cells is due to G2/M phase cell cycle arrest, ROS-mediated necrosis-like cell death and inhibition of PI3K/AKT signalling pathway.
Kong, W; Liu, T; Liu, Y; Song, D; Zhao, X, )		1.88

Treatment

ExcerptReferenceRelevance
"Eremanthin treatment led to G2/M-phase cell cycle arrest."( Anticancer activity of Eremanthin against the human cervical cancer cells is due to G2/M phase cell cycle arrest, ROS-mediated necrosis-like cell death and inhibition of PI3K/AKT signalling pathway.
Kong, W; Liu, T; Liu, Y; Song, D; Zhao, X, )		1.16
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID377924Inhibition of killing activity of CD8+ specific mouse CTL-OE4 cells1999Journal of natural products, Jan, Volume: 62, Issue:1
Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives.
AID377925Inhibition of IL-1-beta-induced ICAM1 expression in human A549 cells1999Journal of natural products, Jan, Volume: 62, Issue:1
Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's2 (28.57)18.2507
2000's1 (14.29)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.10 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dehydrocostus lactone
dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.		710gamma-lactone;
guaiane sesquiterpenoid;
organic heterotricyclic compound;
sesquiterpene lactone		antimycobacterial drug;
antineoplastic agent;
apoptosis inducer;
cyclooxygenase 2 inhibitor;
metabolite;
trypanocidal drug
diosgenin
[no description available]		2.17103beta-sterol;
hexacyclic triterpenoid;
sapogenin;
spiroketal		antineoplastic agent;
antiviral agent;
apoptosis inducer;
metabolite
dioscin
[no description available]		2.1710hexacyclic triterpenoid;
spiroketal;
spirostanyl glycoside;
trisaccharide derivative		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 1.14.18.1 (tyrosinase) inhibitor;
hepatoprotective agent;
metabolite
mokko lactone
mokko lactone: isolated from mokko, Saussurea lappa; structure in first source		710
glycogen
glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.		2.0510
sesquiterpenes
[no description available]		3.2660
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		2.1710caffeic acidgeroprotector;
mouse metabolite
costunolide
[no description available]		2.6930
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9410cysteiniumfundamental metabolite
beta-escin
[no description available]		2.1710
acid phosphatase
Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Alloxan Diabetes
[description not available]		02.4620
Abnormalities, Autosome
[description not available]		01.9810
Bilharziasis
[description not available]		01.9410
Schistosomiasis
Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.		06.9410
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