hs-1793 and Hypoxia
hs-1793 has been researched along with Hypoxia* in 2 studies
Other Studies
2 other study(ies) available for hs-1793 and Hypoxia
| Article | Year |
|---|---|
The resveratrol analog HS-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions.
Tumor hypoxia is associated with treatment resistance, cell proliferation, and metastatic potential, all of which contribute to a poor prognosis. Resveratrol [RES (trans-3,4',5-trihydroxystilbene)], a naturally occurring polyphenol, is enriched in grapes and red wine. This study investigated whether the resveratrol analog HS-1793 modulates the hypoxic status and the level of perfusion in mouse breast cancer FM3A cells. Our data show that HS-1793 decreased the levels of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor protein under hypoxic conditions in FM3A cells. HS-1793 improved perfusion and hypoxic status in tumor tissues and inhibited angiogenesis through HIF-1α suppression in mice. Moreover, HS-1793 inhibited hypoxia-induced cancer stem cell properties and enhanced ionizing radiation-induced apoptosis in hypoxic FM3A cells. Collectively, the resveratrol analog HS-1793 might act as a potent radiosensitizer and be a useful adjuvant agent against radiotherapy-resistant hypoxic cells in solid tumors. Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Cell Movement; Cell Survival; Enzyme-Linked Immunosorbent Assay; Female; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Naphthols; Neoplastic Stem Cells; Neovascularization, Pathologic; Radiation Tolerance; Radiation-Sensitizing Agents; Real-Time Polymerase Chain Reaction; Resorcinols; Resveratrol; Stilbenes; Tumor Cells, Cultured | 2016 |
HS-1793, a recently developed resveratrol analogue protects rat heart against hypoxia/reoxygenation injury via attenuating mitochondrial damage.
Resveratrol is known to exert a cardioprotective effect against hypoxia/reoxygenation (H/R) injury. HS-1793 is a novel, more stable resveratrol analog, but its cardioprotective effects were unknown. The present study aimed to test the cardioprotective effect of HS-1793 against H/R injury and investigate the role of mitochondria in Sprague Dawley rat heart damage using an ex vivo Langendorff system. HS-1793 ameliorated H/R-induced mitochondrial dysfunction by reducing mitochondrial reactive oxygen species production, improving mitochondrial oxygen consumption and suppressing mitochondrial calcium (Ca(2+)) overload during reperfusion. Moreover, HS-1793-treated rat heart showed reduced infarct size. Our data suggest that HS-1793 can protect cardiac against mitochondrial damage following H/R, thereby suppressing injury. Topics: Animals; Calcium; Heart; Hypoxia; Mitochondria; Myocardial Reperfusion Injury; Naphthols; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resorcinols; Resveratrol; Stilbenes | 2013 |