Echinopsine is a natural alkaloid found in plants of the genus Echinops. Its structure features a pyrrolizidine ring system, which is common in many bioactive plant compounds. Echinopsine has shown various pharmacological activities, including anti-inflammatory, analgesic, and anticancer effects. Researchers are interested in its potential therapeutic applications, especially in treating inflammatory conditions and certain types of cancer. However, caution is needed due to the pyrrolizidine alkaloid structure, as some of these compounds can be hepatotoxic. The synthesis of echinopsine involves complex organic chemistry reactions, and researchers are continually working on developing more efficient and environmentally friendly methods for its production.'
echinopsine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6748 |
| CHEBI ID | 4749 |
| SCHEMBL ID | 1809581 |
| MeSH ID | M0050861 |
| Synonym |
|---|
| n-methyl-gamma-quinoline |
| einecs 201-485-3 |
| brn 0122247 |
| n-methyl-4-quinolone |
| 1-methyl-4(1h)-quinolone |
| 4(1h)-quinolone, 1-methyl- |
| 1-methyl-4-quinolone |
| 1-methyl-4(1h)-quinolinone |
| 1,4-dihydro-1-methyl-4-oxoquinoline |
| 4(1h)-quinolinone, 1-methyl- |
| echinopsin |
| echinopsine |
| 83-54-5 |
| AKOS000277978 |
| HMS1648C04 |
| 1-methylquinolin-4-one |
| unii-17mmy7ok1u |
| 17mmy7ok1u , |
| 5-21-08-00210 (beilstein handbook reference) |
| 1-methylquinolin-4(1h)-one |
| STL372984 |
| 4(1h)-quinolinone,1-methyl- |
| BBL028347 |
| echinopsine [mi] |
| DTXSID30232110 |
| CHEBI:4749 |
| SCHEMBL1809581 |
| n-methylquinolin-4-one |
| n-methyl-.gamma.-quinolinone |
| 1-methyl-4-quinolinone |
| ekhinopsin |
| FT-0699406 |
| 1-methyl-1,4-dihydroquinolin-4-one |
| Q4533321 |
| VS-08731 |
| D86440 |
| 1-methyl-1h-quinolin-4-one |
| EN300-7424849 |
| Z1198151716 |
| Class | Description |
|---|---|
| quinolines | A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (52.47) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||