Chlorotrifluoroethylene (CTFE) is a colorless, odorless, nonflammable gas at room temperature. It is a versatile monomer used in the production of various polymers, notably polychlorotrifluoroethylene (PCTFE), a highly fluorinated thermoplastic known for its exceptional chemical resistance, high-temperature stability, and excellent dielectric properties. CTFE is synthesized through a multi-step process involving the reaction of trichloroethylene with hydrogen fluoride in the presence of a catalyst. The synthesis is typically carried out at high temperatures and pressures. CTFE is studied extensively due to its unique properties and applications. Its chemical inertness and thermal stability make it suitable for use in applications that require resistance to corrosive chemicals and extreme temperatures, such as in chemical processing equipment, seals, gaskets, and high-performance coatings. Its dielectric properties have led to its use in electrical insulation, capacitors, and other electronic components. CTFE is also used in the production of specialty polymers for biomedical applications, where its biocompatibility and resistance to degradation are valuable assets. However, CTFE is considered a potent greenhouse gas and its release into the atmosphere should be minimized.'
| ID Source | ID |
|---|---|
| PubMed CID | 6594 |
| SCHEMBL ID | 18665 |
| MeSH ID | M0066225 |
| Synonym |
|---|
| ethene, chlorotrifluoro- |
| ethylene, chlorotrifluoro- |
| 1-chloro-1,2,2-trifluoroethene |
| 79-38-9 |
| CFE , |
| brn 1740373 |
| daiflon |
| ethylene, trifluorochloro- |
| 1,1,2-trifluoro-2-chloroethylene |
| trifluoromonochloroethylene |
| ctfe |
| 12 f |
| trifluorovinyl chloride |
| trithene |
| un1082 |
| 2-chloro-1,1,2-trifluoroethylene |
| fluoroplast 3 |
| chlorotrifluoroethylene |
| trifluorochloroethylene |
| einecs 201-201-8 |
| genetron 1113 |
| hsdb 2806 |
| chlortrifluoraethylen [german] |
| 1-chloro-1,2,2-trifluoroethylene |
| kel-f |
| trifluorchlorethylen [czech] |
| monochlorotrifluoroethylene |
| chlorotrifluoroethene |
| chlorotrifluoroethylene, 98% |
| A839670 |
| 1-chloranyl-1,2,2-tris(fluoranyl)ethene |
| AKOS007930325 |
| 9002-83-9 |
| trifluorochloroethylene, inhibited |
| af215gw34g , |
| ec 201-201-8 |
| trifluorochloroethylene, inhibited [un1082] [poison gas] |
| unii-af215gw34g |
| chlortrifluoraethylen |
| ethene, 1-chloro-1,2,2-trifluoro- |
| 4-01-00-00704 (beilstein handbook reference) |
| trifluorchlorethylen |
| cfc-1113 |
| chlorotrifluoroethylene [hsdb] |
| freon 1113 |
| SCHEMBL18665 |
| chlorotrifluorethylene |
| chlorotrifluoroetylene |
| cf2=cfcl |
| trifluoro-chloroethylene |
| 9036-80-0 |
| 1-chloro-1,2,2-trifluoro-ethene |
| un 1082 |
| c2f3cl |
| DTXSID3026485 |
| mfcd00000822 |
| Q408215 |
| fluorolube grease |
| halocarbon oil 0.8 |
Polychlorotrifluoroethylene (3.1 oil) is a nonflammable hydraulic fluid. It is composed of oligomers of different carbon chain lengths (C5 to C9)
| Excerpt | Reference | Relevance |
|---|---|---|
| "Polychlorotrifluoroethylene (3.1 oil) is a nonflammable hydraulic fluid composed of chlorotrifluoroethylene (CTFE) oligomers of different carbon chain lengths (C5 to C9), primarily six (trimer) and eight (tetramer) carbons. " | ( Comparative hepatotoxicity of two polychlorotrifluoroethylenes (3.1 oils) and two chlorotrifluoroethylene (CTFE) oligomers in male Fischer 344 rats. DelRaso, NJ; Flemming, CD; Godin, CS; Jones, CE; Mattie, DR; Wall, HG, 1991) | 1.11 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " They are structurally related to PFDA, and CTFE tetramer acid has caused toxic effects in rodents that are similar to those observed following PFDA administration." | ( Assessment of the potential genotoxicity of perfluorodecanoic acid and chlorotrifluoroethylene trimer and tetramer acids. Cifone, MA; Godin, CS; Lawlor, TE; Murli, H; Myhr, BC; Young, RR, 1992) | 0.52 |
| " Moreover, S-(2-chloro-1,1,2-trifluoroethyl)-DL-alpha-methylcysteine, which cannot be metabolized by pyridoxal phosphate-dependent enzymes, was not toxic to isolated renal tubular cells." | ( Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. Anders, MW; Dohn, DR; Lash, LH; Leininger, JR; Quebbemann, AJ, 1985) | 0.27 |
| " In vitro systems allow for a more rapid identification of toxic compounds and can be utilized to study mechanisms of toxicity at the cellular and subcellular level." | ( In vitro methodologies for enhanced toxicity testing. DelRaso, NJ, 1993) | 0.29 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition to the formation of tetramer acid, rats dosed with tetramer also indicated comparable amounts of trimer acid." | ( Evidence of hepatic conversion of C6 and C8 chlorotrifluoroethylene (CTFE) oligomers to their corresponding CTFE acids. Auten, KL; DelRaso, NJ; Higman, HC; Leahy, HF, 1991) | 0.54 |
| " The degree of nephrotoxicity by all three compounds exhibited a dose-response from 1-25 mg/kg." | ( Nephrotoxicity of halogenated vinyl cysteine compounds. Gandolfi, AJ; Nagle, RB; Plescia, FH; Soltis, JJ, 1981) | 0.26 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 12 (37.50) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 5 (15.63) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (55.22) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (2.70%) | 5.53% |
| Reviews | 1 (2.70%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 35 (94.59%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||