2-chloro-1,1-difluoroethylene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-chloro-1,1-difluoroethylene: volatile metabolite of halothane [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9664
MeSH ID	M0070062

Synonyms (33)

Synonym
ethene, 2-chloro-1,1-difluoro-
ethylene, 2-chloro-1,1-difluoro-
f 1122
1,1-difluorochloroethylene
2-chloro-1,1-difluoroethylene
brn 1736774
einecs 206-625-7
hcfc 1122
fc 1122
r 1122
2-chloro-1,1-difluoroethene
359-10-4
A823037
AKOS006228408
qgf1p560aw ,
4-01-00-00703 (beilstein handbook reference)
unii-qgf1p560aw
FT-0611678
chloro-1,1-difluoroethylene
r-1122
2,2-difluoro-1-chloroethene
freon r 1122
R1122 ,
chloro-1,1-difluoroethylene, 2-
2-chloro-1,1-difluoro-ethene
hcfc-1122
1,1-difluoro-2-chloroethylene
cf2=chcl
DTXSID3073898
mfcd00042134
Q26841345
methyl4-(3-thienyl)benzoate
2-chloro-1,1-difluoroethylene(fc-1122)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

Pathway	Proteins	Compounds
Halothane Pathway, Pharmacokinetics	4	1

Research

Studies (16)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	13 (81.25)	18.7374
1990's	3 (18.75)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.21 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	4.30 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.21)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dithionite Dithionite: Dithionite. The dithionous acid ion and its salts.	1.96	1	sulfur oxide; sulfur oxoanion
enflurane Enflurane: An extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate.. enflurane : An ether in which the oxygen atom is connected to 2-chloro-1,1,2-trifluoroethyl and difluoromethyl groups.	1.96	1	ether; organochlorine compound; organofluorine compound	anaesthetic
halothane [no description available]	3.98	14	haloalkane; organobromine compound; organochlorine compound; organofluorine compound	inhalation anaesthetic
isoflurane Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.	3.07	5	organofluorine compound	inhalation anaesthetic
diisopropyl 1,3-dithiol-2-ylidenemalonate diisopropyl 1,3-dithiol-2-ylidenemalonate: structure in first source	1.97	1	isopropyl ester
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.66	3	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
piperonyl butoxide [no description available]	1.97	1	benzodioxoles	pesticide synergist
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	1.97	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
ethane Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.	1.96	1	alkane; gas molecular entity	plant metabolite; refrigerant
1,1,1-trifluoro-2-chloroethane 1,1,1-trifluoro-2-chloroethane: volatile metabolite of halothane	3.57	9	organofluorine compound
trifluoroacetic acid Trifluoroacetic Acid: A very strong halogenated derivative of acetic acid. It is used in acid catalyzed reactions, especially those where an ester is cleaved in peptide synthesis.. trifluoroacetic acid : A monocarboxylic acid that is the trifluoro derivative of acetic acid.	2.66	3	fluoroalkanoic acid	human xenobiotic metabolite; NMR chemical shift reference compound; reagent
chlorotrifluoroethylene [no description available]	1.96	1
fluorides [no description available]	2.38	2	halide anion; monoatomic fluorine
nadp [no description available]	2.38	2
benzphetamine Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222). benzphetamine : Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity.	1.98	1	amphetamines; tertiary amine	adrenergic uptake inhibitor; appetite depressant; dopamine uptake inhibitor; sympathomimetic agent

Condition	Relationship Strength	Studies
Acute Liver Injury, Drug-Induced [description not available]	2.65	3
Anoxemia [description not available]	1.96	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	1.96	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.65	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.95	1
Benign Neoplasms [description not available]	1.95	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1.95	1
Hyperthyroid [description not available]	1.97	1
Liver Dysfunction [description not available]	1.97	1
Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.	1.97	1
Liver Diseases Pathological processes of the LIVER.	1.97	1

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