Compounds > calothrixin b
Page last updated: 2024-12-11

calothrixin b

Description

calothrixin B: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9817721
CHEMBL ID362573
SCHEMBL ID5222737
MeSH IDM0376607

Synonyms (5)

Synonym
calothrixin b
CHEMBL362573
254114-34-6
SCHEMBL5222737
DTXSID80431277
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (69)

Assay IDTitleYearJournalArticle
AID1701942Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701959Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G2/M phase at 5 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422409Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702013Octanol/water partition coefficient, log P of the compound2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702045Induction of apoptosis in human NCI-H460 cells assessed as nuclear fragmentation at 5 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422411Induction of human DNA topoisomerase 1-mediated DNA cleavage at 1 to 10 uM by polyacrylamide gel electrophoresis2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422416Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701938Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702043Induction of apoptosis in human HCT-116 cells assessed as nuclear fragmentation at 5 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422419Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702014Octanol/buffer distribution coefficient, log D of the compound at pH 7.42018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702006Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring decrease in intensity of positive CD band at 13.5*10^-6 mol/L by CD spectroscopy2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422414Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702007Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring decrease in intensity of negative CD band at 6.6*10^-6 mol/L by CD spectroscopy2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422420Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701943Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422427Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID292937Cytotoxicity against human HeLa cells by MTT assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Structure-activity delineation of quinones related to the biologically active Calothrixin B.
AID422418Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701958Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G1 phase at 5 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422407Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID292939Cytotoxicity against CV1 cells by MTT assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Structure-activity delineation of quinones related to the biologically active Calothrixin B.
AID1701940Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID670966Antimalarial activity against chloroquine sensitive Plasmodium falciparum FCR-32012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives.
AID422428Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701953Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G0/G1 phase at 5 uM incubated for 20 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422426Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701944Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422429Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701966Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G1 phase at 5 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422415Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701949Anticlonogenic activity against human NCI-H460 cells assessed as inhibition of colony formation incubated for 48 hrs followed by compound washout with PBS and measured after 14 days by crystal violet staining based analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701941Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701990Induction of apoptosis in human HeLa cells assessed as activation of PARP incubated for 48 hrs by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702044Induction of apoptosis in human NCI-H460 cells assessed as chromatin condensation at 5 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702008Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring decrease in intensity of negative CD band at 13.5*10^-6 mol/L by CD spectroscopy2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422408Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702011Binding affinity to calf thymus DNA assessed as binding constant at 298 K by double beam UV-vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422410Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701948Anticlonogenic activity against human HCT-116 cells assessed as inhibition of colony formation incubated for 48 hrs followed by compound washout with PBS and measured after 14 days by crystal violet staining based analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422422Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701939Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422424Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702042Induction of apoptosis in human HCT-116 cells assessed as chromatin condensation at 5 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID246030Cytotoxicity against HeLa cell lines2004Journal of medicinal chemistry, Sep-23, Volume: 47, Issue:20
Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.
AID1701999Binding affinity to calf thymus DNA assessed as hypochromic effect measured at 264 nm at 3*10^-5 mol/L by double beam UV-Vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701989Induction of apoptosis in human HeLa cells assessed as increase in cleaved PARP levels at 10 uM by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701969Inhibition of wild-type recombinant human topoisomerase 1 expressed in baculovirus infected Sf9 cells assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA at 200 uM incubated for 30 mins by ethidium bromide staining based gel e2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422405Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701937Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422413Reversal of drug-stabilized human DNA topoisomerase 1-DNA binary complex at 5 uM within 5 mins by polyacrylamide gel electrophoresis in presence of 0.35 M NaCl2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701961Induction of cell cycle arrest in human HeLa cells assessed as accumulation of cells at G1 phase at 1 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422423Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422432Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701960Induction of cell cycle arrest in human HeLa cells assessed as accumulation of cells at S phase at 1 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701993Induction of apoptosis in human HCT-116 cells assessed as reduction in PARP protein levels at 5 uM incubated for 48 hrs by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422417Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422430Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID292938Cytotoxicity against mouse P388 cells by MTT assay2007Bioorganic & medicinal chemistry letters, Jan-01, Volume: 17, Issue:1
Structure-activity delineation of quinones related to the biologically active Calothrixin B.
AID1701974Induction of DNA cleavage in supercoiled pBlue-Script KS(+) plasmid DNA assessed as closed circular DNA formation at 250 uM incubated for 1 hr in presence of Fe2+ and DTT by ethidium bromide staining based gel electrophoresis method2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701978Induction of DNA damage in human HCT-116 cells assessed as tail length at 5 uM incubated for 48 hrs by alkaline Comet assay relative to control2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701945Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702005Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring decrease in intensity of positive CD band at 6.6*10^-6 mol/L by CD spectroscopy2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422431Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701991Induction of apoptosis in human NCI-H460 cells assessed as increase in cleaved PARP protein levels at 5 uM incubated for 48 hrs by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422425Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701954Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at S phase at 5 uM incubated for 20 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422421Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422406Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (36.84)29.6817
2010's12 (63.16)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.44

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.44 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index5.25 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.44)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		2.0810halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0710aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.02101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
carbazole
carbazole: structure in first source		2.1710carbazole
ethidium bromide
[no description available]		2.1710organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		7.7730metal allergen;
nickel group element atom;
platinum group metal atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.4920delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
ferric chloride
ferric chloride: RN given refers to cpd with MF of Fe-Cl3; used to induce experimental arterial thrombosis to evaluate antithrombotic agents		2.0810iron coordination entityastringent;
Lewis acid
murrayaquinone a
murrayaquinone A: a carbazole alkaloid from Murraya (Rutaceae); structure given in first source		7.4620
calothrixin a
calothrixin A: structure in first source		4.86100
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Colon
[description not available]		02.1710
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1710
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