Compounds > calothrixin a
Page last updated: 2024-11-12

calothrixin a

Description

calothrixin A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9926867
CHEMBL ID435295
SCHEMBL ID2231059
MeSH IDM0376608

Synonyms (5)

Synonym
CHEMBL435295
calothrixin a
SCHEMBL2231059
20-oxido-10-aza-20-azoniapentacyclo[11.8.0.03,11.04,9.014,19]henicosa-1(13),3(11),4,6,8,14,16,18,20-nonaene-2,12-dione
DTXSID601046871
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (84)

Assay IDTitleYearJournalArticle
AID422423Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422429Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701939Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911370Cytotoxicity against human MDA-MB-231 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1701941Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422424Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1911379Inhibition of DNA topoisomerase I (unknown origin) relaxation activity at 100 uM incubated for 30 mins by chemiDoc system
AID1911371Cytotoxicity against human HCT-116 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1701944Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701937Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422409Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701949Anticlonogenic activity against human NCI-H460 cells assessed as inhibition of colony formation incubated for 48 hrs followed by compound washout with PBS and measured after 14 days by crystal violet staining based analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422428Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701964Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at sub-G1 phase at 2 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701965Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at sub-G1 phase at 5 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422416Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702014Octanol/buffer distribution coefficient, log D of the compound at pH 7.42018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701940Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911369Cytotoxicity against human SH-SY5Y cells expressing low level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1911403Induction of cell cycle arrest in human A-375 cells assessed as accumulation of cells at S phase at 80 nM incubated for 24 hrs by PI based flow cytometric analysis (RVB = 26.73%)
AID1701942Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422430Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1702013Octanol/water partition coefficient, log P of the compound2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701988Induction of apoptosis in human HeLa cells assessed as increase in cleaved PARP levels at 1 uM by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422408Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422418Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701971Inhibition of recombinant human topoisomerase 2 assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA at < 100 uM incubated for 30 mins by ethidium bromide staining based gel electrophoresis method2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701943Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422425Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701977Induction of DNA damage in human HCT-116 cells assessed as tail length at 0.5 uM incubated for 48 hrs by alkaline Comet assay relative to control2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701969Inhibition of wild-type recombinant human topoisomerase 1 expressed in baculovirus infected Sf9 cells assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA at 200 uM incubated for 30 mins by ethidium bromide staining based gel e2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422406Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422419Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701994Induction of apoptosis in human HCT-116 cells assessed as reduction in PARP protein levels at 3 uM incubated for 48 hrs by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911375Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay
AID1911384Antiproliferative activity against doxorubicin resistant human HCT-116 cells measured after 72 hrs by MTT assay
AID1911402Induction of cell cycle arrest in human A-375 cells assessed as accumulation of cells at G1 phase at 80 nM incubated for 24 hrs by PI based flow cytometric analysis (RVB = 52.94%)
AID1702002Binding affinity to calf thymus DNA assessed as hypsochromic shift absorbance measured at 284 nM at 3*10^-5 mol/L by double beam UV-Vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911372Cytotoxicity against human MCF7 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1911401Antiinvasive activity in human A-375 cells assessed as reduction in cell migration at 40 nM incubated for 24 hrs by crystal violet staining method
AID1701954Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at S phase at 5 uM incubated for 20 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702004Binding affinity to calf thymus DNA assessed as hyperchromic shift measured at 432 nm at 3*10^-5 mol/L by double beam UV-Vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422417Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422431Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422407Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 0.1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701962Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G1/S phase at 2 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701957Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at S phase at 5 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1702003Binding affinity to calf thymus DNA assessed as hyperchromic shift measured at 362 nm at 3*10^-5 mol/L by double beam UV-Vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701982Induction of apoptosis in human HCT-116 cells assessed as chromatin condensation at 2 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911399Inhibition of colony formation in human HCT-116 cells at 40 nM incubated for 48 hrs by crystal violet staining method
AID422411Induction of human DNA topoisomerase 1-mediated DNA cleavage at 1 to 10 uM by polyacrylamide gel electrophoresis2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701945Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701983Induction of apoptosis in human HCT-116 cells assessed as nuclear fragmentation at 2 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911404Induction of cell cycle arrest in human A-375 cells assessed as accumulation of cells at G2 phase at 80 nM incubated for 24 hrs by PI based flow cytometric analysis (RVB = 20.34%)
AID422405Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID670966Antimalarial activity against chloroquine sensitive Plasmodium falciparum FCR-32012Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives.
AID1911373Cytotoxicity against human A-375 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1701985Induction of apoptosis in human NCI-H460 cells assessed as nuclear fragmentation at 2 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422415Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701948Anticlonogenic activity against human HCT-116 cells assessed as inhibition of colony formation incubated for 48 hrs followed by compound washout with PBS and measured after 14 days by crystal violet staining based analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID246030Cytotoxicity against HeLa cell lines2004Journal of medicinal chemistry, Sep-23, Volume: 47, Issue:20
Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.
AID1702011Binding affinity to calf thymus DNA assessed as binding constant at 298 K by double beam UV-vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701970Inhibition of recombinant human topoisomerase 2 assessed as decrease in relaxation of supercoiled pBlue-Script KS(+) plasmid DNA at 200 uM incubated for 30 mins by ethidium bromide staining based gel electrophoresis method2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1701992Induction of apoptosis in human NCI-H460 cells assessed as increase in cleaved PARP protein levels at 3 uM incubated for 48 hrs by Western blot analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422422Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 10 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701960Induction of cell cycle arrest in human HeLa cells assessed as accumulation of cells at S phase at 1 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422421Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1911378Aqueous solubility of the compound in saline equilibrating for 24 hrs by HPLC analysis
AID1702000Binding affinity to calf thymus DNA assessed as hypochromic effect at 3*10^-5 mol/L by double beam UV-Vis spectroscopic analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911376Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay
AID422413Reversal of drug-stabilized human DNA topoisomerase 1-DNA binary complex at 5 uM within 5 mins by polyacrylamide gel electrophoresis in presence of 0.35 M NaCl2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701984Induction of apoptosis in human NCI-H460 cells assessed as chromatin condensation at 2 uM incubated for 48 hrs by acridine orange/propidium iodide double staining based fluorescence microscopy analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422426Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G0 phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422420Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1911374Cytotoxicity against human A549 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay
AID1701953Induction of cell cycle arrest in human HCT-116 cells assessed as accumulation of cells at G0/G1 phase at 5 uM incubated for 20 hrs by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID1911385Antiproliferative activity against doxorubicin sensitive human HCT-116 cells measured after 72 hrs by MTT assay
AID1911398Inhibition of colony formation in human A-375 cells at 40 nM incubated for 48 hrs by crystal violet staining method
AID422414Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701938Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422432Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at G2/M phase at 10 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID422427Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at subG1 phase at 1 uM treated for 3 hrs followed by drug washout and 15 hrs incubation in drug free medium by flow cytometry2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
AID1701961Induction of cell cycle arrest in human HeLa cells assessed as accumulation of cells at G1 phase at 1 uM incubated for 3 to 20 hrs in presence of 0.3 uM mitotic inhibitor nocodazole by propidium iodide staining based flow cytometry analysis2018Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues.
AID422410Cell cycle arrest in human CCRF-CEM cells assessed as accumulation at S phase at 0.1 uM treated for 3 hrs measured for 15 hrs after nocodazole treatment by flow cytometry in presence of mitotic inhibitor nocodazole2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Calothrixins, a new class of human DNA topoisomerase I poisons.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's7 (50.00)24.3611
2020's2 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.36

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.36 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.07 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.36)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0710aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
vitamin k 3
Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.		2.02101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
ethidium bromide
[no description available]		2.1710organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.4820metal allergen;
nickel group element atom;
platinum group metal atom
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.4920delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
calothrixin b
calothrixin B: structure in first source		4.86100
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.2110
Lung Neoplasms
Tumors or cancer of the LUNG.		02.2110
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