Compounds > biotin sulfone
Page last updated: 2024-11-06

biotin sulfone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Biotin sulfone is a synthetic analog of biotin, a vitamin essential for various metabolic processes. It is known to inhibit biotin-dependent enzymes, particularly carboxylases, by acting as a competitive inhibitor. This inhibition occurs due to the sulfone group replacing the carboxyl group in biotin, which is essential for binding to the enzyme active site. Biotin sulfone's ability to inhibit carboxylases has led to its investigation as a potential therapeutic agent in certain conditions, including cancer and metabolic disorders. Studies have shown that biotin sulfone can suppress the growth of cancer cells and regulate blood glucose levels in diabetic models. However, further research is needed to understand its potential clinical applications and safety profile. The study of biotin sulfone is important as it provides insights into the mechanisms of biotin-dependent enzymes and the potential for developing new therapeutic strategies.'

biotin sulfone: RN given for (3aS-(3aalpha,4beta,6aalpha))-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

biotin sulfone : A member of the class of biotins that is biotin sulfoxide with a sulfone group replacing the sulfoxide. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID83863
CHEBI ID74092
SCHEMBL ID710629
MeSH IDM0272598

Synonyms (30)

Synonym
5-[(3as,4s,6ar)-5,5-dioxido-2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl]pentanoic acid
EN300-24308
5-[(3as,4s,6ar)-2,5,5-trioxo-hexahydro-1h-5lambda6-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
biotin sulfone
40720-05-6
5-[(3as,4s,6ar)-2,5,5-trioxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid
AKOS001254221
1h-thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, 5,5-dioxide, (3as,4s,6ar)-
unii-22451myq9x
1h-thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, 5,5-dioxide, (3as-(3aalpha,4beta,6aalpha))-
22451myq9x ,
C20387
[3as-(3aa,4b,6aa)]-5,5-dioxide-hexahydro-2-oxo-1h-thieno[3,4-d]imidazole-4-pentanoic acid
5,5-dioxide biotin
CHEBI:74092
SCHEMBL710629
QPFQYMONYBAUCY-ZKWXMUAHSA-N
5-((1r,5s,6s)-3,7,7-trioxo-7-thia-2,4-diazabicyclo[3.3.0]oct-6-yl)pentanoic acid
[3as-(3aa,4b,6aa)]- 5,5-dioxide-hexahydro-2-oxo-1h-thieno[3,4-d]imidazole-4-pentanoic acid
[3as-(3aa,4b,6aa)]- 5,5-dioxide-hexahydro-2-oxo-1h-thieno[3,4-d]imidazole-4-pentanoate
Z190662994
Q27144407
HY-113268
CS-0059469
5-((3as,4s,6ar)-5,5-dioxido-2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl)pentanoic acid
MS-23928
5-((3as,4s,6ar)-5,5-dioxido-2-oxohexahydro-1h-thieno[3,4-d]imidazol-4-yl)pentanoicacid
1h-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 5,5-dioxide, (3as,4s,6ar)-
DTXSID301124523
mfcd08444234
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
biotinsCompounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton.
sulfoneAn organosulfur compound having the structure RS(=O)2R (R =/= H).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (40.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.03 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		2.0810aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
butyric acid
Butyric Acid: A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.. butyrate : A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.. butyric acid : A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.		6.9210fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
5,6-dihydroorotate
4,5-dihydroorotic acid: RN given refers to cpd without isomeric designation; structure. dihydroorotic acid : A pyrimidinemonocarboxylic acid that results from the base-catalysed cyclisation of N(alpha)-carbethoxyasparagine.		2.1310monocarboxylic acid;
N-acylurea;
pyrimidinemonocarboxylic acid;
secondary amide
orotic acid
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.. orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.		2.1310pyrimidinemonocarboxylic acidEscherichia coli metabolite;
metabolite;
mouse metabolite
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.		2.1310diazine;
pyrimidines		Daphnia magna metabolite
permethrin
hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141		2.0810cyclopropanecarboxylate ester;
cyclopropanes		agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide
d-biotin-d-sulfoxide
biotin sulfoxide : A sulfoxide that is the S-oxide of biotin.		1.9910biotins;
sulfoxide		metabolite
bisnorbiotin
bisnorbiotin: bacterial catabolite of biotin		1.9910heterocyclic fatty acid
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		3.67100biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
kaempferol
[no description available]		2.13107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
mannans
[no description available]		2.0710
oxybiotin
oxybiotin: structure in first source		6.9210
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0410
Cancer of Lung
[description not available]		02.0810
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0810
Aura
[description not available]		01.9310
Audiogenic Epilepsy
[description not available]		01.9310
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		06.9310
Epilepsy, Reflex
A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)		01.9310