Page last updated: 2024-11-12
angiotensin iii, ile(7)-
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
angiotensin III, Ile(7)-: angiotensin II antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 14728930 |
| CHEMBL ID | 2371409 |
| MeSH ID | M0159143 |
Synonyms (12)
| Synonym |
|---|
| angiotensin iii, isoleucine(7)- |
| 7-ile-angiotensin iii |
| aiii, ile(7)- |
| 52498-25-6 |
| angiotensin iii, ile(7)- |
| 7-isoleucine-aiii |
| CHEMBL2371409 |
| angiotensin iii inhibitor (human) |
| argininyl-valinyl-tyrosinyl-isoleucinyl-histidinyl-prolinyl-isoleucine |
| [ile7] angiotensin iii |
| (2s,3s)-2-((s)-1-((6s,9s,12s,15s,18s)-18-((1h-imidazol-4-yl)methyl)-1,6-diamino-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxamido)-3-methylpentanoic acid |
| (2s,3s)-2-[[(2s)-1-[(2s)-2-[[(2s,3s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1h-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]a |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID172170 | In vivo agonist angiotensin II like activity was measured in rat blood pressure increase by a 1 ug iv injection | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4 | The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. |
| AID167773 | In vitro agonist angiotensin II like activity was measured in the rabbit aorta strip assay | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4 | The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. |
| AID39185 | In vitro antagonist activity against Angiotensin II receptor was measured in the rabbit aorta strip assay | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4 | The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. |
| AID179466 | Antagonist activity ID50 was measured in vivo in the rat blood pressure assay | 1988 | Journal of medicinal chemistry, Apr, Volume: 31, Issue:4 | The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.97
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.97) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||