Compounds > albizziin
Page last updated: 2024-12-07

albizziin

Description

Albizziin is a non-protein amino acid that was first isolated from the plant Albizzia saman. It is a potent inhibitor of glutamate decarboxylase, the enzyme responsible for converting glutamate to GABA. This inhibition leads to increased levels of glutamate in the brain, which can have neurotoxic effects. Albizziin has also been shown to have anti-inflammatory and anti-tumor activity. Due to its potent biological activity, albizziin has been studied for its potential therapeutic applications in treating neurological disorders, cancer, and inflammation. The synthesis of albizziin involves a complex multi-step process that starts from the amino acid L-glutamine. Albizziin is an interesting molecule due to its unique structure and its potent biological activity. It is a promising target for the development of new drugs for the treatment of a wide range of diseases.'

albizziin: RN given refers to parent cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92891
CHEBI ID6173
SCHEMBL ID690347
MeSH IDM0049023

Synonyms (55)

Synonym
nsc-132089
albizzine
l-albizziin
l-alanine, 3-[(aminocarbonyl)amino]-
l-2-amino-3-ureidopropionic acid
C08264
albizziin
l-albizziine
1483-07-4
A-4650
zinc01531037
(2s)-2-amino-3-(carbamoylamino)propanoic acid
A808754 ,
(s)-2-amino-3-ureidopropanoicacid
AKOS006237907
3-ureido-l-alanin
l-alanine, 3-((aminocarbonyl)amino)-
albizziin (van)
nsc 132089
einecs 216-046-1
l-beta-ureidoalanine
rw59as48cr ,
unii-rw59as48cr
l-(-)-2-amino-3-ureidopropionic acid
propionic acid, 2-amino-3-ureido-, l-
nsc 407273
albizziin [mi]
3-((aminocarbonyl)amino)-l-alanine
SCHEMBL690347
CHEBI:6173
(2s)-2-amino-3-ureido-propanoic acid
3-[(aminocarbonyl)amino]alanine #
GZYFIMLSHBLMKF-REOHCLBHSA-N
(2s)-2-ammonio-3-(carbamoylamino)propanoate
(2s)-3-(aminocarbonylamino)-2-azaniumyl-propanoate
c4h9n3o3
albizziin (h-dap(conh2)-oh)
mfcd00007952
l-(-)2-amino-3-ureidopropionic acid
h-beta-(ureido)-ala-oh
AS-63003
C90278
albizziin, aldrichcpr
h--((aminocarbonyl)amino)-ala-oh;h-dap(carbamoyl)-oh
(s)-2-amino-3-ureidopropanoic acid
Q27107112
AMY22571
HY-121167
butyl 4-?hydroxybenzoate
(butyl paraben)
DTXSID501318659
EN300-7026825
CS-0079579
nsc823850
nsc-823850
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (57.14)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.39 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		1.9710aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
glutamine
Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.		2.3820amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
rotenone
Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.		1.9710organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
diazooxonorleucine
Diazooxonorleucine: An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed). 6-diazo-5-oxo-L-norleucine : A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes.		1.9710amino acid zwitterion;
diazo compound;
ketone;
non-proteinogenic L-alpha-amino acid		analgesic;
antibacterial agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
bacterial metabolite;
EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor;
EC 3.5.1.2 (glutaminase) inhibitor;
EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor;
EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor;
EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor;
EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor;
glutamine antagonist
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		1.9710isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
acivicin
[no description available]		1.9710isoxazoles;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		antileishmanial agent;
antimetabolite;
antimicrobial agent;
antineoplastic agent;
EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor;
glutamine antagonist;
metabolite
antimycin a
Antimycin A: An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed). antimycin A : A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.		1.9710amidobenzoic acid
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome
[description not available]		01.9610
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		01.9710
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