Page last updated: 2024-12-07
adenylyl-(2'-5')-adenosine
Description
Adenylyl-(2'-5')-adenosine, also known as 2-5A, is a unique nucleotide that plays a crucial role in the innate antiviral response. It is synthesized from ATP by 2-5A synthetase enzymes, which are activated by viral double-stranded RNA. 2-5A then binds to and activates RNase L, an endoribonuclease that degrades viral and cellular RNA, inhibiting viral replication. This makes 2-5A a key molecule in the antiviral defense system. It is actively studied as a potential target for novel antiviral therapies, particularly against RNA viruses like influenza, HIV, and hepatitis C. Research is also exploring its potential use in cancer therapy and immunotherapy.'
A2'p5'A : A (2'->5')-dinucleotide in which the two nucleoside components connected by the (2'->5')-phosphodiester linkage are adenosine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 102238 |
| CHEBI ID | 75801 |
| MeSH ID | M0098031 |
Synonyms (21)
| Synonym |
|---|
| 2273-76-9 |
| einecs 218-884-3 |
| [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2r,3r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate |
| adenylyl-(2'.5')-adenosine |
| ammonium adenylyl-2',5'-adenosine |
| adenosine, adenylyl-(2'-5')- |
| adenylyl-(2'-5')-adenosine |
| EPITOPE ID:191096 |
| adenylyl(2'-5')phosphoadenine |
| CHEBI:75801 , |
| a2'p5'a |
| adenosin-2'-yl adenosin-5'-yl hydrogen phosphate |
| adenylyl-(2'->5')-adenosine |
| ap(2'-5')a |
| adenylyl-2',5'-adenosine |
| adenosin-2'-yl adenosin-5'-yl phosphate |
| phosphoric acid adenosin-2'-yl ester adenosin-5'-yl ester |
| adenylyl-[2'-5']-adenosine |
| Q27145551 |
| adenylyl-(2'-->5')-adenosine |
| DTXSID901311243 |
Drug Classes (1)
| Class | Description |
|---|
| (2'->5')-dinucleotide | Any dinucleotide where the two components are connected via a (2'->5')-phosphodiester linkage. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.92
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 11.92 (24.57) | | Research Supply Index | 2.48 (2.92) | | Research Growth Index | 4.40 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (9.09%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (90.91%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |