Compounds > adenylyl-(2'-5')-adenylyl-(2'-5')adenosine
Page last updated: 2024-12-07
adenylyl-(2'-5')-adenylyl-(2'-5')adenosine
Description
Adenylyl-(2'-5')-adenylyl-(2'-5')adenosine, also known as 2-5A, is a linear trimer of adenosine monophosphate linked by 2'-5' phosphodiester bonds. It is a potent antiviral molecule that is synthesized in response to viral infection. The synthesis of 2-5A is catalyzed by a family of enzymes called 2-5A synthetases, which are activated by double-stranded RNA. Once synthesized, 2-5A binds to and activates an endoribonuclease called RNase L. This enzyme degrades viral RNA, thereby inhibiting viral replication. 2-5A is a key component of the innate immune response to viral infection. It is studied extensively to understand the mechanisms of antiviral immunity and to develop new antiviral therapies. 2-5A has also been shown to have anti-tumor and immunomodulatory effects.'
adenylyl-(2'-5')-adenylyl-(2'-5')adenosine: inhibits protein synthesis in intact mouse lymphocytes, hepatocytes & bone marrow cells [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 122642 |
| SCHEMBL ID | 13020760 |
| MeSH ID | M0098026 |
Synonyms (7)
| Synonym |
|---|
| 70062-83-8 |
| a2'p5'a2'p5'a |
| [5-(6-aminopurin-9-yl)-4-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [2-(6-aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate |
| a2'-5'a2'-5'a |
| adenosine, adenylyl-(2'-5')-adenylyl-(2'-5')- |
| adenylyl-(2'-5')-adenylyl-(2'-5')adenosine |
| SCHEMBL13020760 |
Research
Studies (8)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.09
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.09 (24.57) | | Research Supply Index | 2.20 (2.92) | | Research Growth Index | 4.28 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |