| Assay ID | Title | Year | Journal | Article |
|---|
| AID1145480 | Solubility of the compound | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID1145431 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 5.74 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID57046 | The compound was tested for inhibitory activity against DNA relaxation by DNA topoisomerase I at dose 100 uM | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID9798 | Compound was evaluated for in vitro antiproliferative activity against A172 human CNS cancer cell line | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring. |
| AID234609 | Tested for (median survival time of treated/control animals) x100 at dosage of 60 mg/kg | 1994 | Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
| Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues. |
| AID235764 | Therapeutic index was measured on P-388 leukemia cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID100153 | The compound was tested in vivo for life prolongation against mouse L1210 tumor cells; Not tested | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID1145434 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 144 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID210946 | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. |
| AID8446 | In vitro cytotoxicity of compound was tested against 9KB cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID57047 | The compound was tested for inhibitory activity against DNA relaxation by DNA topoisomerase I at dose 30 uM | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID42763 | Compound was evaluated for in vitro antiproliferative activity against CAOV-3 human ovarian cancer cell line | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring. |
| AID1145436 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 26.3 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID95318 | Compound was evaluated for in vitro antiproliferative activity against KATO-III human gastric cancer cell line | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring. |
| AID261687 | Antiproliferative activity against NCI60 cell line | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6
| Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. |
| AID57044 | The compound was tested for inhibitory activity against DNA relaxation by DNA topoisomerase I at dose 10 uM | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID153187 | The compound was tested in vivo for life prolongation against mouse P388 tumor cells at 8 mg/kg concentration | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID234602 | Tested for (median survival time of treated/control animals) x100 at dosage of 120 mg/kg | 1994 | Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
| Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues. |
| AID1145435 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 287 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID53782 | Compound was evaluated for in vitro antiproliferative activity against DLD-1 human colon cancer cell line | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring. |
| AID1145459 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as host survival at 5.74 umol/kg, ip after 30 days | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID1145461 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as host survival at 287 umol/kg, ip after 30 days | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID234606 | Tested for (median survival time of treated/control animals) x100 at dosage of 30 mg/kg | 1994 | Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
| Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues. |
| AID8615 | The cytotoxic activity was in vitro tested by 9PS assay method | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID152254 | This is the dose at which optimal activity was observed against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID210947 | Inhibition of Topoisomerase I by cleavage complex formation in intact human HL-60 cells | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. |
| AID1145462 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as host survival at 26.3 umol/kg, ip after 30 days | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID234604 | Tested for (median survival time of treated/control animals) x100 at dosage of 240 mg/kg | 1994 | Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
| Antitumor agents. 7. Synthesis and antitumor activity of novel hexacyclic camptothecin analogues. |
| AID98220 | Compound was evaluated for in vitro antiproliferative activity against L1210 mouse leukemia cell line | 1998 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 8, Issue:14
| Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring. |
| AID1145432 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 28.7 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID120239 | Optimal activity expressed as percentage treated to that of control was measured in vivo against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID152255 | Antileukemic activity against P-388 leukemia cells was measured at given dose range | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID132641 | The cytotoxic activity in vitro by 9KB assay method | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin. |
| AID261688 | Activity against NCI60 cell line xenograft in nude mouse by HF assay | 2006 | Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6
| Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. |
| AID152253 | Lowest toxicity was observed at this dose against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID1145460 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as host survival at 28.7 umol/kg, ip after 30 days | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| AID1145433 | Antileukemic activity against mouse L1210 cells allografted in BDF1 mouse assessed as increase in life span of host at 71.8 umol/kg, ip relative to control | 1976 | Journal of medicinal chemistry, May, Volume: 19, Issue:5
| Experiments of synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |