| Assay ID | Title | Year | Journal | Article |
|---|
| AID137248 | L-1210 mouse leukemia life prolongation activity was measured as T/C (mean survival time of treated animals divided by the mean survival time of the controls times 100) at dose 10 mg/kg | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12
| Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. |
| AID152253 | Lowest toxicity was observed at this dose against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID94100 | Compound was tested for active dose in L1210 Leukemia assay; 10-40 mg/kg | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. |
| AID137370 | L-1210 mouse leukemia life prolongation activity was measured as T/C (mean survival time of treated animals divided by the mean survival time of the controls times 100) at dose 80 mg/kg | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12
| Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. |
| AID1123927 | Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase in mouse survival time at 0.4 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID235764 | Therapeutic index was measured on P-388 leukemia cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID1123932 | Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase in mouse survival time at 3.7 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID1123928 | Antitumor activity against mouse P388 cells allografted in mouse assessed as increase in mouse survival time at 11.1 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID210946 | Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells | 1993 | Journal of medicinal chemistry, Sep-03, Volume: 36, Issue:18
| Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs. |
| AID98164 | Concentration that inhibits the proliferation of L1210 cells by 50% | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. |
| AID120239 | Optimal activity expressed as percentage treated to that of control was measured in vivo against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID94103 | Compound was tested for maximum percentage T/C in L1210 Leukemia assay at 40 mg/kg (no cures out of 6) | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. |
| AID8446 | In vitro cytotoxicity of compound was tested against 9KB cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID1123929 | Antitumor activity against mouse P388 cells allografted in mouse assessed as increase in mouse survival time at 3.7 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID1123933 | Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase in mouse survival time at 1.2 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID137250 | L-1210 mouse leukemia life prolongation activity was measured as T/C (mean survival time of treated animals divided by the mean survival time of the controls times 100) at dose 20 mg/kg | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12
| Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. |
| AID152254 | This is the dose at which optimal activity was observed against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID1123971 | Antitumor activity against human HeLa cells assessed as inhibition of radioactive thymidine incorporation into acid-insoluble material by DNA sedimentation assay | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID56563 | Concentration that produces 50% DNA cleavage mediated by DNA topoisomerase I | 1989 | Journal of medicinal chemistry, Mar, Volume: 32, Issue:3
| Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity. |
| AID1123930 | Antitumor activity against mouse P388 cells allografted in mouse assessed as increase in mouse survival time at 1.2 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID1123931 | Antitumor activity against mouse L1210 cells allografted in mouse assessed as increase in mouse survival time at 11.1 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID152255 | Antileukemic activity against P-388 leukemia cells was measured at given dose range | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5
| Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID137251 | L-1210 mouse leukemia life prolongation activity was measured as T/C (mean survival time of treated animals divided by the mean survival time of the controls times 100) at dose 40 mg/kg | 1987 | Journal of medicinal chemistry, Dec, Volume: 30, Issue:12
| Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin. |
| AID1123923 | Antitumor activity against mouse P388 cells allografted in mouse assessed as increase in mouse survival time at 0.4 mg/kg, iv for 4 to 9 days relative to control | 1979 | Journal of medicinal chemistry, Mar, Volume: 22, Issue:3
| Prodrug analogues of the antitumor alkaloid camptothecin. |
| AID94106 | Compound was tested for toxic dose in L1210 Leukemia assay | 1986 | Journal of medicinal chemistry, Aug, Volume: 29, Issue:8
| Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |