Page last updated: 2024-12-07
9-methoxycamptothecin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
10-methoxycamptothecin: a radiotracer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
9-methoxycamptothecin: RN given refers to (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 97283 |
| CHEMBL ID | 75854 |
| SCHEMBL ID | 1035263 |
| MeSH ID | M0085442 |
| PubMed CID | 123617 |
| CHEMBL ID | 522112 |
| SCHEMBL ID | 1004508 |
| MeSH ID | M0085442 |
Synonyms (48)
| Synonym |
|---|
| CHEMBL75854 |
| 19685-10-0 |
| 10-methoxycamptothecin |
| 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (s)- |
| nsc-111533 |
| NCI60_000257 |
| 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-9-methoxy-, (s)- |
| nsc 111533 |
| SCHEMBL1035263 |
| Q-100242 |
| (s)-10-methoxycamptothecin, aldrichcpr |
| AKOS030573697 |
| 10-methoxycamptothecine |
| DTXSID60941445 |
| A14767 |
| HY-N0446 |
| CS-0008979 |
| MS-26165 |
| (19s)-19-ethyl-19-hydroxy-7-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione |
| E88614 |
| PD164882 |
| camptothecin, 9-methoxy- |
| 9-methoxycamptothecin |
| 39026-92-1 |
| nsc-176323 |
| 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione-, 4-ethyl-4-hydroxy-10-methoxy-, (s)- |
| NSC176323 , |
| camptothecin,9-methoxy |
| NCI60_001450 |
| {1h-pyrano[3',} {4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione-,} 4-ethyl-4-hydroxy-10-methoxy-, (s)- |
| CHEMBL522112 |
| nsc 176323 |
| SCHEMBL1004508 |
| DTXSID00192292 |
| ncgc00385478-01_c21h18n2o5_1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4s)- |
| NCGC00385478-01 |
| AKOS037514539 |
| F17695 |
| XVMZDZFTCKLZTF-NRFANRHFSA-N |
| mfcd03840473 |
| ZB1864 |
| (s)-4-ethyl-4-hydroxy-10-methoxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione |
| (19s)-19-ethyl-19-hydroxy-8-methoxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione |
| HY-N6011 |
| CS-0032150 |
| MS-26164 |
| (s)-4-ethyl-4-hydroxy-10-methoxy-1,12-dihydro-14h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h)-dione |
| PD125185 |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (22)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID152255 | Antileukemic activity against P-388 leukemia cells was measured at given dose range | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID235764 | Therapeutic index was measured on P-388 leukemia cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID152097 | Compound was evaluated for antitumor activity against P-338 leukemia in mice at the dose of 1.6 mg/kg; T/C=Survival time of treated/control animals*100 | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. |
| AID152114 | Compound was evaluated for antitumor activity against P-338 leukemia in mice, active dose range of the compound; Lowest dose administered, dose range was 0.4-1.6 mg/kg | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. |
| AID426063 | Antitumor activity against human HT-29 cells by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. |
| AID152245 | Antitumor activity against P-338 leukemia in mice. | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. |
| AID426062 | Antitumor activity against human A549/ATCC cells by SRB method | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15 | 7-Cycloalkylcamptothecin derivatives: Preparation and biological evaluation. |
| AID152254 | This is the dose at which optimal activity was observed against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID152253 | Lowest toxicity was observed at this dose against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID120239 | Optimal activity expressed as percentage treated to that of control was measured in vivo against P-388 leukemia cells | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID152247 | Antitumor activity against P-338 leukemia in mice. | 1986 | Journal of medicinal chemistry, Nov, Volume: 29, Issue:11 | Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues. |
| AID8446 | In vitro cytotoxicity of compound was tested against 9KB cells. | 1980 | Journal of medicinal chemistry, May, Volume: 23, Issue:5 | Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogues. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID337695 | Antibacterial activity against Escherichia coli ATCC 25922 at 5 ug after 48 hrs by silica gel plate-based INT-formazan method | |||
| AID337694 | Antibacterial activity against Bacillus subtilis ATCC 6633 at 5 ug after 48 hrs by silica gel plate-based INT-formazan method | |||
| AID381253 | Cytotoxicity against mouse P388 cells | |||
| AID381252 | Cytotoxicity against human KB cells | |||
| AID380079 | Cytotoxicity against human A2780 cells by clonogenic assay | 2006 | Journal of natural products, Feb, Volume: 69, Issue:2 | Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (23)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.78
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.78) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| Other | 19 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||