acyclovir monophosphate profile

acyclovir monophosphate: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	135422933
CHEMBL ID	517814
SCHEMBL ID	1477723
SCHEMBL ID	11308931
MeSH ID	M0086198
PubMed CID	135434163
CHEMBL ID	7193
SCHEMBL ID	9472121
MeSH ID	M0086198

Synonym
acyclovir-monophosphate
6h-purin-6-one, 2-amino-1,9-dihydro-9-[[2-(phosphonooxy)ethoxy]methyl]-
acv-mp
2-[(2-amino-6-oxo-1h-purin-9-yl)methoxy]ethyl dihydrogen phosphate
acyclovir monophosphate
66341-16-0
FT-0661421
CHEMBL517814
2-[(2-amino-6-oxo-3h-purin-9-yl)methoxy]ethyl dihydrogen phosphate
6h-purin-6-one, 2-amino-1,9-dihydro-9-((2-(phosphonooxy)ethoxy)methyl)-
acyclo-gmp
6j91qr22o8 ,
unii-6j91qr22o8
acycloguanosine monophosphate
SCHEMBL1477723
SCHEMBL11308931
2-amino-1,9-dihydro-9-[[2-(phosphonooxy)ethoxy]methyl]-6h-purin-6-one
acyclovir, monophosphate
mfcd00797590
W-203461
C90516
acyclovir phosphate
acyclic guanosine monophosphate; acyclovir monophosphate
2-[(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)methoxy]ethyl dihydrogen phosphate
4DG ,
2-[(2-amino-1,6-dihydro-6-oxo-9h-purin-9-yl)methoxy]ethyl dihydrogen phosphate
2-((2-amino-6-oxo-1h-purin-9(6h)-yl)methoxy)ethyl dihydrogen phosphate
DTXSID90984966
2-[(6-hydroxy-2-imino-2,3-dihydro-9h-purin-9-yl)methoxy]ethyl dihydrogen phosphate
Q27454619
2-((2-amino-6-oxo-1h-purin-9(6h)-yl)methoxy)ethyldihydrogenphosphate
HY-17422B
CS-0066107
{[2-(2-amino-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-ethoxy]-hydroxy-diphosphate
bdbm50033666
2-[(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)methoxy]ethyl trihydrogen diphosphate(acvdp)
acyclovir-diphosphate
2-[(2-amino-6-oxo-1,6-dihydro-9h-purin-9-yl)methoxy]ethyl trihydrogen diphosphate
2-[(2-amino-6-oxo-1h-purin-9-yl)methoxy]ethyl phosphono hydrogen phosphate
acv-dp
CHEMBL7193 ,
acyclovir diphosphate
SCHEMBL9472121
DTXSID501314988
66341-17-1

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Purine nucleoside phosphorylase	Homo sapiens (human)	Ki	0.0080	0.0000	0.5289	7.0000	AID156077; AID1571174; AID164923; AID164924; AID164927; AID164941
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
inosine catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
urate biosynthetic process	Purine nucleoside phosphorylase	Homo sapiens (human)
positive regulation of T cell proliferation	Purine nucleoside phosphorylase	Homo sapiens (human)
positive regulation of alpha-beta T cell differentiation	Purine nucleoside phosphorylase	Homo sapiens (human)
allantoin metabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
nucleobase-containing compound metabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
inosine catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
deoxyinosine catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
deoxyadenosine catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
purine ribonucleoside salvage	Purine nucleoside phosphorylase	Homo sapiens (human)
IMP catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
nicotinamide riboside catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
immune response	Purine nucleoside phosphorylase	Homo sapiens (human)
nucleotide biosynthetic process	Purine nucleoside phosphorylase	Homo sapiens (human)
response to xenobiotic stimulus	Purine nucleoside phosphorylase	Homo sapiens (human)
positive regulation of interleukin-2 production	Purine nucleoside phosphorylase	Homo sapiens (human)
purine-containing compound salvage	Purine nucleoside phosphorylase	Homo sapiens (human)
dAMP catabolic process	Purine nucleoside phosphorylase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nucleoside binding	Purine nucleoside phosphorylase	Homo sapiens (human)
purine nucleobase binding	Purine nucleoside phosphorylase	Homo sapiens (human)
purine-nucleoside phosphorylase activity	Purine nucleoside phosphorylase	Homo sapiens (human)
protein binding	Purine nucleoside phosphorylase	Homo sapiens (human)
phosphate ion binding	Purine nucleoside phosphorylase	Homo sapiens (human)
identical protein binding	Purine nucleoside phosphorylase	Homo sapiens (human)
guanosine phosphorylase activity	Purine nucleoside phosphorylase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Purine nucleoside phosphorylase	Homo sapiens (human)
cytoplasm	Purine nucleoside phosphorylase	Homo sapiens (human)
cytosol	Purine nucleoside phosphorylase	Homo sapiens (human)
secretory granule lumen	Purine nucleoside phosphorylase	Homo sapiens (human)
extracellular exosome	Purine nucleoside phosphorylase	Homo sapiens (human)
ficolin-1-rich granule lumen	Purine nucleoside phosphorylase	Homo sapiens (human)
cytoplasm	Purine nucleoside phosphorylase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (30)

Assay ID	Title	Year	Journal	Article
AID359821	Activity of human wild type DNA polymerase gamma assessed as amplitude of excision of compound from correctly paired DNA primer during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359798	Activity of wild type HSV1 DNA polymerase UL42 assessed as rate of excision of compound from correctly paired DNA primer during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359809	Activity of wild type HSV1 DNA polymerase UL42 assessed as amplitude of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359802	Activity of wild type HSV1 DNA polymerase UL42 assessed as rate of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID689096	Selectivity ratio of CC50 for african green monkey Vero cells to EC50 for acyclovir-resistant HSV1 L2	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID359799	Activity of wild type HSV1 DNA polymerase UL42 assessed as amplitude of excision of compound from correctly paired DNA primer during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID689094	Cytotoxicity against human Jurkat cells up to 2000 uM after 48 hrs by trypan blue staining	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID359820	Activity of human wild-type DNA polymerase gamma assessed as rate of excision of compound from correctly paired DNA primer during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID357984	Activity of human wild type DNA polymerase gamma assessed as amplitude of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359816	Activity of human wild type DNA polymerase gamma assessed as rate of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359807	Activity of wild type HSV1 DNA polymerasemerse UL42 assessed as amplitude of excision of compound from correctly paired DNA primer during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359817	Activity of human wild type DNA polymerase gamma assessed as amplitude of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359813	Activity of human wild type DNA polymerase gamma assessed as amplitude of excision of compound from correctly paired DNA primer during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359806	Activity of wild type HSV1 DNA polymerase UL42 assessed as rate of excision of compound from correctly paired DNA primer during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359803	Activity of wild type HSV1 DNA polymerase UL42 assessed as amplitude of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359822	Activity of human wild type DNA polymerase gamma assessed as rate of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359808	Activity of wild type HSV1 DNA polymerase UL42 assessed as rate of excision of compound from 3'-frayed DNA primer with 8 mispaired bases at 3' end during fast phase of excision in presence of 100 uM dNTPs	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID359812	Activity of human wild type DNA polymerase gamma assessed as rate of excision of compound from correctly paired DNA primer during fast phase of excision	2007	The Journal of biological chemistry, Aug-24, Volume: 282, Issue:34	Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
AID689099	Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID689098	Selectivity ratio of CC50 for african green monkey Vero cells to EC50 for HSV1 L2	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID689097	Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID689100	Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Phosphoramidate derivatives of acyclovir: synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro.
AID164939	Binding affinity against hydrophobic pocket of Purine nucleoside Phosphorylase	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
AID164940	Binding affinity against phosphate binding site of Purine nucleoside Phosphorylase	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
AID164941	Binding affinity against purine binding site of Purine nucleoside Phosphorylase	1993	Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24	Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.
AID1571174	Inhibition of human PNP	2018	MedChemComm, Dec-01, Volume: 9, Issue:12	The transition to magic bullets - transition state analogue drug design.
AID156077	Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay	1993	Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22	9-[(Phosphonoalkyl)benzyl]guanines. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.
AID164924	Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride	1995	Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6	[[(Guaninylalkyl)phosphinico]methyl]phosphonic acids. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.
AID164927	In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.	1996	Journal of medicinal chemistry, Feb-16, Volume: 39, Issue:4	Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase.
AID164923	Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)	1995	Journal of medicinal chemistry, Mar-17, Volume: 38, Issue:6	[[(Guaninylalkyl)phosphinico]methyl]phosphonic acids. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (36.36)	18.7374
1990's	7 (31.82)	18.2507
2000's	2 (9.09)	29.6817
2010's	5 (22.73)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.56%)	5.53%
Trials	0 (0.00%)	5.53%
Reviews	2 (11.11%)	6.00%
Reviews	1 (20.00%)	6.00%
Case Studies	1 (5.56%)	4.05%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Observational	0 (0.00%)	0.25%
Other	14 (77.78%)	84.16%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
foscarnet Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.	2.06	1	0	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	1.95	1	0	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
galactose galactopyranose : The pyranose form of galactose.	1.96	1	0	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.	3.34	1	1	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
tricalcium phosphate tricalcium phosphate: a form of tricalcium phosphate used as bioceramic bone replacement material; see also records for alpha-tricalcium phosphate, beta-tricalcium phosphate, calcium phosphate; apatitic tricalcium phosphate Ca9(HPO4)(PO4)5(OH) is the calcium orthophosphate leading to beta tricalcium phosphate Ca3(PO4)2 (b-TCP). calcium phosphate : A calcium salt composed of calcium and phosphate/diphosphate ions; present in milk and used for the mineralisation of calcified tissues.	2.08	1	0	calcium phosphate
vidarabine phosphate Vidarabine Phosphate: An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.	2.66	3	0
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	2.07	1	0	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
thymidine 5'-triphosphate thymidine 5'-triphosphate: RN given refers to parent cpd. dTTP : A thymidine phosphate having a triphosphate group at the 5'-position.	2.03	1	0	pyrimidine 2'-deoxyribonucleoside 5'-triphosphate; thymidine phosphate	Escherichia coli metabolite; mouse metabolite
organophosphonates hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.	2.03	1	0	divalent inorganic anion; phosphite ion
oligonucleotides [no description available]	1.97	1	0
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	7.12	16	1	2-aminopurines; oxopurine	antimetabolite; antiviral drug
2'-deoxyguanosine 5'-phosphate 2'-deoxyguanosine 5'-phosphate: RN given refers to parent cpd.. 2'-deoxyguanosine 5'-monophosphate : A purine 2'-deoxyribonucleoside 5'-monophosphate having guanine as the nucleobase.	2.03	1	0	deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-monophosphate	Escherichia coli metabolite; mouse metabolite
deoxyguanosine triphosphate [no description available]	2.03	1	0	deoxyguanosine phosphate; guanyl deoxyribonucleotide; purine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
guanosine monophosphate Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.	1.95	1	0	guanosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	biomarker; Escherichia coli metabolite; metabolite; mouse metabolite
guanine [no description available]	5.36	4	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
acyclovir triphosphate [no description available]	4.68	5	0
1,4-dideoxy-1,4-iminoarabinitol, (2r-(2alpha,3beta,4beta))-isomer [no description available]	3.27	1	0	pyrrolidines
galidesivir [no description available]	3.27	1	0
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	3.27	1	0	2-aminopurines; oxopurine	antimetabolite; antiviral drug
inosine [no description available]	3.27	1	0	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
8-amino-9-(2-thienylmethyl)guanine [no description available]	3.27	1	0
8-amino-9-benzylguanine 8-amino-9-benzylguanine: structure given in first source	3.27	1	0
forodesine forodesine: structure in first source	3.27	1	0	dihydroxypyrrolidine; pyrrolopyrimidine
peldesine peldesine: potent inhibitor of human CCRF-CEM T-cell proliferation; structure given in first source	3.27	1	0
immucillin g immucillin G: structure in first source	3.27	1	0	dihydroxypyrrolidine; pyrrolopyrimidine
ulodesine ulodesine: a purine nucleoside phosphorylase inhibitor	3.27	1	0
9-deaza-9-(3-thienylmethyl)guanine [no description available]	3.27	1	0
8-aminoguanosine [no description available]	1.98	1	0

Condition	Relationship Strength	Studies	Trials
Herpes Simplex Virus Infection [description not available]	2.07	1	0
HIV Coinfection [description not available]	2.07	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	2.07	1	0
HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).	2.07	1	0
Benign Neoplasms [description not available]	2.08	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.08	1	0
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2.06	1	0
Cell Transformation, Viral An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.	1.95	1	0
Furrow Keratitis [description not available]	3.34	1	1
Viremia The presence of viruses in the blood.	6.97	1	0
Hepatitis, Viral, Animal INFLAMMATION of the LIVER in animals due to viral infection.	1.97	1	0
Retinal Diseases Diseases involving the RETINA.	1.97	1	0

acyclovir monophosphate

Description

Cross-References

Synonyms (45)

Protein Targets (1)

Inhibition Measurements

Biological Processes (17)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (30)

Research

Studies (22)

Study Types

acyclovir monophosphate

Description

Cross-References

Synonyms (45)

Protein Targets (1)

Inhibition Measurements

Biological Processes (17)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (30)

Research

Studies (22)

Study Types

Related Drugs (28)

Related Conditions (12)