Page last updated: 2024-10-15

9-deazaguanine

Cross-References

ID SourceID
PubMed CID135461003
CHEMBL ID367746
SCHEMBL ID4872325
SCHEMBL ID1715820
MeSH IDM0206370

Synonyms (42)

Synonym
nsc344522
65996-58-9
nsc-344522
9-deazaguanine
9DG ,
DB04356
2-amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one
2-amino-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
AKOS000320629
2-amino-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
bdbm50108005
CHEMBL367746 ,
A835298
2-amino-3h-pyrrolo[3,2-d]pyrimidin-4(5h)-one
4h-pyrrolo(3,2-d)pyrimidin-4-one, 2-amino-1,5-dihydro-
2-amino-3,5-dihydro-4h-pyrrolo(3,2-d)pyrimidine-4-one
unii-h2o1dd3can
h2o1dd3can ,
nsc 344522
AKOS006329593
4h-pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro-
FT-0649229
4h-pyrrolo[3,2-d]pyrimidin-4-one,2-amino-3,5-dihydro-
SCHEMBL4872325
SCHEMBL1715820
2-amino-1,5-dihydro-4h-pyrrolo[3,2-d]pyrimidin-4-one #
2-amino-3,5-dihydropyrrolo(3,2-d)pyrimidin-4-one
W-203443
DTXSID20216202
mfcd09540493
2-amino-3,5-dihydro-4h-pyrrolo[3,2-d]pyrimidin-4-one
DS-10645
2-amino-1,5-dihydro-4h-pyrrolo(3,2-d)pyrimidin-4-one
4h-pyrrolo(3,2-d)pyrimidin-4-one, 2-amino-3,5-dihydro-
2-amino-3,5-dihydro-4h-pyrrolo(3,2-d)pyrimidin-4-one
SB38177
Q27457004
CS-0079471
2-amino-1,5-dihydro-4h-pyrrolo[3,2-d]pyrimidin-4-one
2-amino-3 pound not5-dihydropyrrolo[3 pound not2-d]pyrimidin-4-one
PD057040
HY-121106

Bioavailability

ExcerptReference
" Pharmacokinetic analysis of BzDAG in the rat showed it to be 48% orally bioavailable (at a dose of 5 mg/kg)."( Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds.
Allan, PW; Bennett, LL; Erion, MD; Montgomery, JA; Niwas, S; Noker, PE; Rose, LM, 1993
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Purine nucleoside phosphorylase Bos taurus (cattle)Kd0.16500.00000.66673.3000AID694065; AID694066
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Purine nucleoside phosphorylase Bos taurus (cattle)Kieq7.40000.00003.47507.4000AID694063
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Processvia Protein(s)Taxonomy
purine ribonucleoside salvagePurine nucleoside phosphorylase Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
purine-nucleoside phosphorylase activityPurine nucleoside phosphorylase Bos taurus (cattle)
guanosine phosphorylase activityPurine nucleoside phosphorylase Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID694063Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay2012Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
AID1767038Inhibition of hexa-his tagged Helicobacter pylori XGHPRT using guanine and PRib-PP as substrate2021Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9
AID66419Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes2002Journal of medicinal chemistry, Jan-03, Volume: 45, Issue:1
Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.
AID694065Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis2012Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
AID694066Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry2012Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (37.50)18.2507
2000's4 (25.00)29.6817
2010's5 (31.25)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.88%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (88.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]