4-fluoro-3-nitrophenyl azide

Description

4-fluoro-3-nitrophenyl azide is a versatile reagent used in organic synthesis, particularly in the preparation of various nitrogen-containing compounds. Its synthesis typically involves diazotization of 4-fluoro-3-nitroaniline followed by reaction with sodium azide. 4-fluoro-3-nitrophenyl azide is known to undergo a variety of reactions, including Staudinger reactions, 1,3-dipolar cycloadditions, and electrophilic aromatic substitution reactions. It has been used to synthesize a wide range of compounds, including pharmaceuticals, agrochemicals, and materials. The compound is often studied due to its ability to act as a photoaffinity labeling reagent, allowing for the investigation of protein-ligand interactions. The presence of both a fluorine atom and a nitro group provides unique electronic and steric properties, making it an attractive building block for the design of new molecules with specific biological activities.'

4-fluoro-3-nitrophenyl azide: used as an affinity label for insulin to give mono-azide-nitrophenyl-insulin derivatives [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]