Page last updated: 2024-09-04

17-hydroxypregnanolone and pregnanolone

17-hydroxypregnanolone has been researched along with pregnanolone in 16 studies

Compound Research Comparison

Studies
(17-hydroxypregnanolone)
Trials
(17-hydroxypregnanolone)
Recent Studies (post-2010)
(17-hydroxypregnanolone)
Studies
(pregnanolone)
Trials
(pregnanolone)
Recent Studies (post-2010) (pregnanolone)
17001,984111666

Protein Interaction Comparison

ProteinTaxonomy17-hydroxypregnanolone (IC50)pregnanolone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-1Mus musculus (house mouse)0.071
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.101
GABA theta subunitRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.101

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199013 (81.25)18.7374
1990's1 (6.25)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Holsboer, F; Knorr, D1
Baker, K; Bevan, BR; Jenkins, JM; Pennington, GW; Savvas, M; Taylor, NF1
Heger, W; Neubert, D1
Heger, W; Hoyer, GA; Neubert, D1
Homoki, J; Solyom, J; Teller, WM1
Heger, W; Meister, R; Merker, HJ; Neubert, D; Sames, K1
Lambert, JG; Schoonen, WG; Van Oordt, PG1
Kodama, M; Kodama, T; Totani, R1
Matsumoto, K; Nagareda, T; Takeyama, M1
Hirose, K; Suzuki, K; Tamaoki, B1
Drayer, NM; Nagel, GT; van der Ploeg, KR; Volmer, M; Wolthers, BG1
Carolsfeld, J; Collins, PM; Scott, AP; Sherwood, NM1
Auchus, RJ; Flück, CE; Miller, WL1
DE COURCY, C; SCHNEIDER, JJ1
BELL, M; VARLEY, H1
DiMartino Nardi, J; Freeman, K; Grinstein, G; Saenger, P; Vuguin, P1

Other Studies

16 other study(ies) available for 17-hydroxypregnanolone and pregnanolone

ArticleYear
Determination of urinary 17-hydroxypregnanolone by gas chromatography-mass spectrometry in patients with congenital adrenal hyperplasia.
    Journal of steroid biochemistry, 1977, Volume: 8, Issue:11

    Topics: Adolescent; Adrenocortical Hyperfunction; Adult; Child; Chromatography, Gas; Female; Humans; Male; Mass Spectrometry; Pregnanes; Pregnanolone

1977
Abnormal steroid excretion in gestational trophoblastic disease complicated by ovarian theca-lutein cysts.
    Journal of clinical pathology, 1986, Volume: 39, Issue:6

    Topics: Adult; Chromatography, Gas; Female; Humans; Male; Ovarian Cysts; Pregnancy; Pregnanediol; Pregnanetriol; Pregnanolone; Steroids; Trophoblastic Neoplasms; Uterine Neoplasms

1986
Determination of ovulation and pregnancy in the marmoset (Callithrix jacchus) by monitoring of urinary hydroxypregnanolone excretion.
    Journal of medical primatology, 1987, Volume: 16, Issue:3

    Topics: Animals; Callithrix; Callitrichinae; Chromatography, High Pressure Liquid; Female; Ovulation Detection; Pregnancy; Pregnancy, Animal; Pregnanes; Pregnanolone; Reference Values

1987
Identification of the main gestagen metabolite in marmoset (Callithrix jacchus) urine by NMR and MS spectroscopy.
    Journal of medical primatology, 1988, Volume: 17, Issue:1

    Topics: Animals; Callithrix; Callitrichinae; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Pregnancy; Pregnanes; Pregnanolone

1988
Detection of late onset steroid 21-hydroxylase deficiency by capillary gas chromatographic profiling of urinary steroids in children and adolescents.
    European journal of pediatrics, 1988, Volume: 147, Issue:3

    Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Child; Child, Preschool; Chromatography, Gas; Female; Humans; Infant; Male; Pregnanes; Pregnanetriol; Pregnanolone; Puberty, Precocious; Steroid Hydroxylases; Tetrahydrocortisol; Virilism

1988
Embryotoxic effects of thalidomide derivatives in the non-human primate Callithrix jacchus. II. Elucidation of the susceptible period and of the variability of embryonic stages.
    Archives of toxicology, 1988, Volume: 61, Issue:3

    Topics: Animals; Callithrix; Embryo, Mammalian; Embryonic and Fetal Development; Female; Gestational Age; Male; Ovulation; Pregnancy; Pregnanolone; Species Specificity; Thalidomide

1988
Quantitative analysis of steroids and steroid glucuronides in the seminal vesicle fluid of feral spawning and feral and cultivated nonspawning African catfish, Clarias gariepinus.
    General and comparative endocrinology, 1988, Volume: 70, Issue:1

    Topics: Androstane-3,17-diol; Animals; Catfishes; Dihydrotestosterone; Etiocholanolone; Gas Chromatography-Mass Spectrometry; Glucuronates; Male; Pregnanolone; Reproduction; Semen; Steroids; Testosterone

1988
Dissociation of chorioadenoma destruens from hydatidiform mole by urinary steroid analysis.
    American journal of obstetrics and gynecology, 1981, Oct-01, Volume: 141, Issue:3

    Topics: 17-Ketosteroids; Chorionic Gonadotropin; Chromatography, Gas; Diagnosis, Differential; Female; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Pregnancy; Pregnanes; Pregnanolone; Uterine Neoplasms

1981
Deficiency of 5 alpha-steroid formation in guinea pig ovaries compared with immature rat and hamster ovaries.
    Journal of steroid biochemistry, 1984, Volume: 21, Issue:4

    Topics: Aging; Animals; Cricetinae; Female; Guinea Pigs; Mesocricetus; Ovary; Oxidoreductases; Pregnanes; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation; Species Specificity; Steroids

1984
In vitro metabolism of 4-pregnenes in ovaries of a freshwater teleost, the ayu (Plecoglossus altivelis): production of 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one and its 5 beta-reduced metabolites, and activation of 3 beta- and 20 beta-hydroxysteroid deh
    General and comparative endocrinology, 1981, Volume: 45, Issue:4

    Topics: 20-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Animals; Enzyme Activation; Female; Fishes; Gonadotropins; Hydroxyprogesterones; Ovary; Pregnanetriol; Pregnanolone; Progesterone

1981
The diagnosis of 21-hydroxylase deficiency in a prematurely born infant on the basis of the urinary steroid excretion pattern.
    Clinica chimica acta; international journal of clinical chemistry, 1982, Apr-23, Volume: 120, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Aging; Androstanes; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Infant, Newborn; Infant, Premature; Male; Pregnanes; Pregnanetriol; Pregnanolone; Pregnenes; Steroid Hydroxylases; Steroids; Tetrahydrocortisone

1982
Reproductive steroids during maturation in a primitive teleost, the Pacific herring (Clupea harengus pallasi).
    General and comparative endocrinology, 1996, Volume: 103, Issue:3

    Topics: 17-alpha-Hydroxyprogesterone; Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Female; Fishes; Gonads; Hydroxyprogesterones; Male; Oocytes; Ovary; Ovulation; Pregnanolone; Seasons; Sexual Maturation; Steroids; Testosterone; Time Factors

1996
The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:8

    Topics: 17-alpha-Hydroxyprogesterone; Adult; Catalysis; Dehydroepiandrosterone; Female; Humans; Kinetics; Leydig Cells; Male; Microsomes; Multienzyme Complexes; Pregnancy; Pregnanolone; Pregnenolone; Progesterone; Progesterone Reductase; Steroid 17-alpha-Hydroxylase; Steroid Isomerases; Steroids; Testis

2003
Enzymatic reduction of the C-20 carbonyl group of tetrahydrocortisone and 17-hydroxypregnanolone.
    The Journal of biological chemistry, 1956, Volume: 223, Issue:2

    Topics: Cortisone; Liver; Pregnanediol; Pregnanolone; Progestins; Tetrahydrocortisone

1956
The estimation of pregnanetriol and 17-hydroxypregnanolone in urine in congenital adrenal hyperplasia.
    Clinica chimica acta; international journal of clinical chemistry, 1960, Volume: 5

    Topics: Adrenal Cortex; Adrenal Hyperplasia, Congenital; Humans; Pregnanediol; Pregnanetriol; Pregnanolone

1960
Prediction models for insulin resistance in girls with premature adrenarche. The premature adrenarche insulin resistance score: PAIR score.
    Hormone research, 2006, Volume: 65, Issue:4

    Topics: Acanthosis Nigricans; Adrenarche; Birth Weight; Black or African American; Body Mass Index; Caribbean Region; Child; Child, Preschool; Female; Glucose Tolerance Test; Hispanic or Latino; Humans; Insulin Resistance; Linear Models; Models, Statistical; Predictive Value of Tests; Pregnanolone; Puberty, Precocious; Regression Analysis; Risk Factors; Sensitivity and Specificity; Time Factors

2006