Page last updated: 2024-09-28

Criss-cross Heart

A developmental malformation of the heart characterized by a twisted but not defective atrioventicular connection. The abnormal rotation of the ventricular mass around its long axis results in the crossing of the inflow streams of the two ventricles. Other features include hypoplasia of the TRICUSPID VALVE and RIGHT VENTRICLE.

Synonyms(2)

Synonym
Criss-cross Heart
Crisscross Heart

Research

Studies (3)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's2 (66.67)18.1394
2010's1 (33.33)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
furosemide0low10
gadolinium0low20

Protein Targets (49)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma1001
AR protein1001
aldehyde dehydrogenase 1 family, member A11001
estrogen receptor 2 (ER beta)1001
cytochrome P450 family 3 subfamily A polypeptide 41001
EWS/FLI fusion protein1001
retinoic acid nuclear receptor alpha variant 11001
farnesoid X nuclear receptor1001
estrogen nuclear receptor alpha1001
aryl hydrocarbon receptor1001
thyrotropin-releasing hormone receptor1001
thyroid hormone receptor beta isoform 21001
nuclear factor erythroid 2-related factor 2 isoform 11001
geminin1001
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
Bile salt export pump0101
Bile salt export pump0101
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Albumin0101
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein1001
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90102
Canalicular multispecific organic anion transporter 10101
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0102
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]