benzocyclobutene profile

Benzocyclobutene is a highly strained cyclic hydrocarbon with a unique structure consisting of a benzene ring fused to a cyclobutene ring. It has attracted significant interest in organic chemistry due to its unusual reactivity and potential for ring-opening reactions. The synthesis of benzocyclobutene involves various approaches, including the photochemical ring closure of o-tolylacetylene and the thermolysis of certain benzocyclobutene derivatives. Research on benzocyclobutene focuses on understanding its unique electronic properties, its role in synthetic transformations, and its potential applications in materials science and drug discovery. Notably, benzocyclobutene derivatives have been explored as building blocks for the construction of complex molecules and as precursors to polymers with interesting properties.'

benzocyclobutene : A carbobicyclic compound that is benzene fused to a cyclobutane ring. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	69667
CHEBI ID	87328
MeSH ID	M0211704

Synonym
c8h8
benzocyclobutene
inchi=1/c8h8/c1-2-4-8-6-5-7(8)3-1/h1-4h,5-6h
bicyclo[4.2.0]octa-1,3,5-triene
benzocyclobutene, 98%
694-87-1
FT-0657962
bicyclo(4.2.0)octa-1,3,5-triene
AKOS004907664
B3863
unii-mf7u8f3ylb
mf7u8f3ylb ,
AM20041021
benzocyclobutane
1,2-dihydrobenzocyclobutene
benzocyclobutene, 1,2-dihydro-
CHEBI:87328
DTXSID3073927
STL452965
mfcd01321219
1,2-dihydrocyclobutabenzene
bicyclo[4.2.0]octa-1(6),2,4-triene
CS-W016636
DS-4372
Q420972
SY052978
F15000
EN300-104400

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
carbobicyclic compound	A bicyclic compound in which all the ring atoms are carbon.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (7.41)	18.2507
2000's	13 (48.15)	29.6817
2010's	11 (40.74)	24.3611
2020's	1 (3.70)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.70%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (96.30%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
spironolactone Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827). spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.	2.45	2	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic
isatin tribulin: endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal;	2.15	1	indoledione	EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
1,3-butadiene buta-1,3-diene : A butadiene with unsaturation at positions 1 and 3.	7	1	butadiene	carcinogenic agent; mutagen
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2	1	pyrrole; secondary amine
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	7.03	1	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
diazomethane Diazomethane: A diazonium compound with the formula CH2N2.. diazomethane : The simplest diazo compound, in which a diazo group is attached to a methylene group.	2.03	1	diazo compound	alkylating agent; antineoplastic agent; carcinogenic agent; poison
2-norbornene norbornene : A bridged compound that is cyclohexane with a methylene bridge between carbons 1 and 4 and a double bond at position 2.	2.13	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	3.18	5	metal allergen; nickel group element atom; platinum group metal atom
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.51	2	cobalt group element atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2	1	copper group element atom; elemental gold
alkenes [no description available]	7.41	1
viridin viridin: bacteriocins of alpha-hemolytic streptococcal isolates; RN given refers to (1S-(1alpha,2alpha,11balpha))-isomer	2.02	1
2-oxindole 2-oxindole: RN given refers to parent cpd; structure. indolin-2-one : An indolinone carrying an oxo group at position 2.	2.15	1	gamma-lactam; indolinone
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.44	2	carbon group element atom; metalloid atom; nonmetal atom

Condition	Relationship Strength	Studies
Dementia Praecox [description not available]	2.15	1
Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.	2.15	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1

benzocyclobutene

Description

Cross-References

Synonyms (28)

Roles (1)

Drug Classes (1)

Research

Studies (27)

Market Indicators

Research Demand Index: 44.55

Study Types