Page last updated: 2024-12-08

valtrate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

valtrate: Baldrisedon contains 100mg extract of Radix Valerianae mexicanae which contains 50mg valepotriate [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID442436
CHEMBL ID402061
CHEBI ID9928
SCHEMBL ID1073699
MeSH IDM0095590

Synonyms (48)

Synonym
ACON0_000478
valtrate [inn]
butanoic acid, 3-methyl-, 4-((acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta(c)pyran-7(1h),2'-oxirane)-1,6-diyl ester, (1s-(1-alpha,6-alpha,7-beta,7a-alpha))-
valtrato [inn-spanish]
valtratum [inn-latin]
4-acetoxymethyl-1,6,7,7a-tetrahydro-1,6-bis(isovaleryloxy)cyclopenta(c)pyran-7-spiro-2'-oxiran
3a,4-dihydro-3,4-dihydroxyspiro(benzofuran-2(3h),2'-oxirane)-6-methanol 6-acetate 3,4-diisovalerate
1,7a-dihydro-1,6-dihydroxyspiro(cyclopenta(c)pyran-7-(6h),2'-oxirane)-4-methanol 4-acetate 1,6-diisovalerate
ccris 5795
einecs 242-174-2
valtrats [german]
(7s)-4-acetoxymethyl-1,6,7,7a-tetrahydro-1alpha,6alpha-bis(isovaleroyl)cyclopent(c)pyran-7-spiro-2-oxiran
baldrisedon
halazuchrome b
valepotriate
MEGXP0_000900
C09801
valtratum
18296-44-1
valtrate
LMPR0102070015
[(1s,6s,7r,7as)-4-(acetoxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1h-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
(1s,6s,7r,7as)-4-[(acetyloxy)methyl]-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)
[(1s,6s,7r,7as)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1h-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate
unii-l3jq035x9b
valtrats
l3jq035x9b ,
valtrato
chebi:9928 ,
CHEMBL402061
AKOS015896850
SCHEMBL1073699
butanoic acid, 3-methyl-, 4-((acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta-(c)pyran-7(1h),2'-oxirane)-1,6-diyl ester, (1s-(1-.alpha.,6-.alpha,,7- .beta.,7a-.alpha.))-
valtrate [mart.]
valtrate [who-dd]
V-2700
AC-34887
(1s,2'r,6s)-4-(acetoxymethyl)-6,7a-dihydro-1h-spiro[cyclopenta[c]pyran-7,2'-oxirane]-1,6-diyl bis(3-methylbutanoate)
HY-N0718
mfcd00868024
Q27108520
BDIAUFOIMFAIPU-KVJIRVJXSA-N
CS-0009735
MS-27416
butanoic acid, 3-methyl-, 1,1'-[(1s,2'r,6s,7as)-4-[(acetyloxy)methyl]-6,7a-dihydrospiro[cyclopenta[c]pyran-7(1h),2'-oxirane]-1,6-diyl] ester
DTXSID501031053
valtrate (mart.)
butanoic acid, 3-methyl-, 4-((acetyloxy)methyl)-6,7a-dihydrospiro(cyclopenta-(c)pyran-7(1h),2'-oxirane)-1,6-diyl ester, (1s-(1-alpha,6-.alpha,,7-beta,7a-alpha))-

Research Excerpts

Overview

Valtrate is a novel epoxy iridoid ester isolated from Chinese herbal medicine Valeriana jatamansi Jones. It has anti-proliferative activity against various human cancer cell lines.

ExcerptReferenceRelevance
"Valtrate is a novel epoxy iridoid ester isolated from Chinese herbal medicine Valeriana jatamansi Jones with anti-proliferative activity against various human cancer cell lines. "( Valtrate as a novel therapeutic agent exhibits potent anti-pancreatic cancer activity by inhibiting Stat3 signaling.
Chen, L; Cheng, G; Cheng, X; Feng, D; Gu, M; Liu, Q; Lv, H; Qian, Y; Song, H; Wu, Y; Yang, B; Zhang, X, 2021
)
3.51

Toxicity

ExcerptReferenceRelevance
" Compounds with free SH groups like cysteine, mercaptoethanol, dithioerythritol, and glutathione were able to suppress the cytotoxicity of the valepotriates in a dose-dependent way, whereas compounds with blocked SH groups did not antagonize these toxic effects."( Effects of thiol compounds versus the cytotoxicity of valepotriates on cultured hepatoma cells.
Anton, R; Beck, JP; Haag-Berrurier, M; Keochanthala-Bounthanh, C, 1990
)
0.28

Pharmacokinetics

ExcerptReferenceRelevance
" The method was successfully applied to pharmacokinetic studies of valtrate in rats."( Development of a LC-MS-MS Method for Quantification of Valtrate and Its Application to Pharmacokinetic Study.
Lin, W; Qiu, J; Sun, L; Wang, G; Zhang, N, 2015
)
0.9
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
fatty acid esterA carboxylic ester in which the carboxylic acid component can be any fatty acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID423380Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay2009Journal of natural products, Apr, Volume: 72, Issue:4
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
AID104474Antiviral activity was determined by measurement of HIV-p24 antigen production in the supernatants of the infected MT-4 cell cultures with acommercially available HIV-antigen kit.2002Bioorganic & medicinal chemistry letters, Oct-21, Volume: 12, Issue:20
New Rev-transport inhibitor with anti-HIV activity from Valerianae Radix.
AID312045Cytotoxicity against human PC3M cells by MTT assay2007Journal of natural products, Dec, Volume: 70, Issue:12
Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1).
AID423379Cytotoxicity against human A549 cells after 24 hrs by MTT assay2009Journal of natural products, Apr, Volume: 72, Issue:4
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
AID423381Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay2009Journal of natural products, Apr, Volume: 72, Issue:4
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
AID499280Inhibition of hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as localization by indirect fluorescent antibody technique2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Concise synthesis of 5,6-dihydrovaltrate leading to enhanced Rev-export inhibitory congener.
AID423382Cytotoxicity against human PC3M cells after 24 hrs by MTT assay2009Journal of natural products, Apr, Volume: 72, Issue:4
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
AID475316Inhibition of hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as protein localization after 12 hrs by indirect fluorescent antibody technique2010Bioorganic & medicinal chemistry letters, Apr-01, Volume: 20, Issue:7
Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.35)18.7374
1990's3 (13.04)18.2507
2000's8 (34.78)29.6817
2010's6 (26.09)24.3611
2020's5 (21.74)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.20 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (4.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (4.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (92.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]