2-acetylpyridine semicarbazone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	9577136
CHEMBL ID	1099026
SCHEMBL ID	5526339
MeSH ID	M0174664

Synonyms (19)

Synonym
[(e)-1-(2-pyridyl)ethylideneamino]urea
(1e)-1-(2-pyridinyl)ethanone semicarbazone
apsc
2-acetylpyridine semicarbazone
2-acetylpyridine-semicarbazone
hapsc
CHEMBL1099026
hydrazinecarboxamide, 2-(1-(2-pyridinyl)ethylidene)-
14534-93-1
AKOS015992570
SCHEMBL5526339
120446-04-0
3N-005
[(e)-[1-(pyridin-2-yl)ethylidene]amino]urea
2-[(e)-1-(2-pyridinyl)ethylidene]-1-hydrazinecarboxamide
2-((e)-1-(2-pyridinyl)ethylidene)-1-hydrazinecarboxamide
mfcd00832644
[(e)-1-pyridin-2-ylethylideneamino]urea
2-acetylpyridine semi-carbazone

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID478787	Selectivity index, ratio of IC50 for mouse J774 cells to MIC for Mycobacterium tuberculosis H37Rv	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
AID478785	Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 7 days by resazurine microtiter assay	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
AID478786	Cytotoxicity against mouse J774 cells after 24 hrs by resazurin assay	2010	European journal of medicinal chemistry, May, Volume: 45, Issue:5	Thiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: anti-Mycobacterium tuberculosis activity and cytotoxicity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	3 (60.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.41 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.36 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (20.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
1,3-butylene glycol 1,3-butylene glycol: RN given refers to cpd without isomeric designation. butane-1,3-diol : A butanediol compound having two hydroxy groups in the 1- and 3-positions.	1.97	1	butanediol; glycol
2-acetylpyridine thiosemicarbazone 2-acetylpyridine thiosemicarbazone: RN given refers to parent cpd	2.41	2
thiosemicarbazone h thiosemicarbazone H: antibacterial & antiparasitic properties; structure given in first source	2.05	1
2-acetylpyridine-4-methyl-3-thiosemicarbazone [no description available]	2.41	2
di-2-pyridyl ketone isonicotinoyl hydrazone di-2-pyridyl ketone isonicotinoyl hydrazone: a chelating agent; structure in first source	2.05	1
guanine [no description available]	2.6	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
8-hydroxyguanine 7,8-dihydro-8-oxoguanine: was substituted for guanine at G(8), G(9), G(14), or G(15) in the human telomeric oligonucleotide 5'-d[AGGGTTAG(8)G(9)GTT AG(14)G(15)GTTAGGGTGT]-3'. 7,8-dihydro-8-oxoguanine : An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.	2.6	1	oxopurine

Condition	Relationship Strength	Studies	Trials
Diabetes Mellitus, Adult-Onset [description not available]	3.8	1	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	3.8	1	1
Female Genital Diseases [description not available]	1.97	1	0
Herpes Simplex Virus Infection [description not available]	1.97	1	0
Genital Diseases, Female Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	1.97	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	1.97	1	0

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