tert-butylacrylamide profile

tert-Butylacrylamide is a versatile monomer used in the synthesis of various polymers and copolymers. It is known for its ability to impart unique properties to materials, such as increased hydrophobicity, improved mechanical strength, and enhanced biocompatibility. The synthesis of tert-butylacrylamide typically involves the reaction of tert-butylamine with acrylic acid or acryloyl chloride. Its effects can vary depending on the application, but it is often used to modify the properties of polymers, such as enhancing their water resistance or improving their adhesion to surfaces. tert-Butylacrylamide is studied due to its potential applications in fields like medicine, pharmaceuticals, and materials science. For example, it has been investigated for its use in drug delivery systems, tissue engineering, and the development of new biocompatible materials. The research interest in tert-butylacrylamide stems from its unique chemical structure, which allows for versatile modifications and the creation of materials with tailored properties.'
```

tert-butylacrylamide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	7877
CHEMBL ID	3184503
SCHEMBL ID	26705
MeSH ID	M0296933

Synonym
nsc 5287
ai3-25002
brn 1742331
einecs 203-505-6
n-(1,1-dimethylethyl)-2-propenamide
tert-butylacrylamide
acrylamide, n-tert-butyl-
n-tert-butylacrylamide
2-propenamide,1-dimethylethyl)-
nsc5287
nsc-5287
107-58-4
2-propenamide, n-(1,1-dimethylethyl)-
inchi=1/c7h13no/c1-5-6(9)8-7(2,3)4/h5h,1h2,2-4h3,(h,8,9
n-tert-butylacrylamide, 97%
n-(tert-butyl)acrylamide
n-tert-butylprop-2-enamide
B0703
NCGC00248285-01
4-04-00-00664 (beilstein handbook reference)
t-bu acrylamide
ec 203-505-6
xj13fsh48k ,
unii-xj13fsh48k
EN300-64881
tox21_301092
NCGC00254992-01
dtxsid1040114 ,
cas-107-58-4
dtxcid9020114
AKOS005174133
FT-0675966
SCHEMBL26705
n-tert-butyl-2-propenamide
n-t-butyl-2-propenamide
n-tert.-butylacrylamide
n-t-butyl acrylamide
n-t-butylacrylamide
CHEMBL3184503
mfcd00026271
n-tert-butyl acrylamide
AS-17781
AMY40862
n- tertiary butylacrylamide
D70371
Q27293858
CS-W013480
Z440633548

Excerpt	Relevance	Reference
" In this study, we investigate nanogel suspensions in order to improve the topical ocular therapy by reducing dosage and frequency of administration."	( Nanogels of methylcellulose hydrophobized with N-tert-butylacrylamide for ocular drug delivery. Hoare, T; Jamard, M; Sheardown, H, 2016)	0.69

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	21.8724	0.0008	17.5051	59.3239	AID1159531
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	61.6448	0.0002	29.3054	16,493.5996	AID743075
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	51.4350	0.0003	23.4451	159.6830	AID743067
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (8.33)	18.2507
2000's	7 (29.17)	29.6817
2010's	14 (58.33)	24.3611
2020's	1 (4.17)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
itaconic acid itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.	2.04	1	dicarboxylic acid; dicarboxylic fatty acid; olefinic compound	fungal metabolite; human metabolite
acrylamide [no description available]	7.13	1	acrylamides; N-acylammonia; primary carboxamide	alkylating agent; carcinogenic agent; Maillard reaction product; mutagen; neurotoxin
acrylic acid acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.	2.98	4	alpha,beta-unsaturated monocarboxylic acid	metabolite
thymol Thymol: A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent.. thymol : A phenol that is a natural monoterpene derivative of cymene.	2.41	1	monoterpenoid; phenols	volatile oil component
n,n'-methylenebisacrylamide [no description available]	2.11	1
thiazoles [no description available]	2.07	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
3-hydroxyflavone 3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.	2.05	1	flavonols; monohydroxyflavone
2-hydroxypropyl methacrylate 2-hydroxypropyl methacrylate : An enoate ester that is the 1-methacryloyl derivative of propane-1,2-diol.	2.05	1	enoate ester	polymerisation monomer
n-isopropylacrylamide N-isopropylacrylamide: can polymerize with glycidyl acrylate to form reactive water-soluble polymer that can react with the amino groups of enzymes-proteins or other ligands	4.03	13
thioflavin t thioflavin T: RN given refers to chloride; structure. thioflavine T : An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo.	2.07	1	organic chloride salt	fluorochrome; geroprotector; histological dye
n,n-dimethylacrylamide [no description available]	1.99	1
samarium Samarium: An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.	2.04	1	f-block element atom; lanthanoid atom
iodine [no description available]	2.04	1	halide anion; monoatomic iodine	human metabolite
pyrene pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.	2.05	1	ortho- and peri-fused polycyclic arene	fluorescent probe; persistent organic pollutant
2-acrylamido-2-methylpropanesulfonate 2-acrylamido-2-methylpropanesulfonate: for detection of alkaline phosphatase; RN given refers to parent cpd; do not confuse with AMPS cpd	2.45	2	organosulfonic acid
oxazolidin-2-one Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents.. oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.. oxazolidinone : An oxazolidine containing one or more oxo groups.	2.04	1	carbamate ester; oxazolidinone	metabolite
sperm motility inhibitor 2 [no description available]	2.04	1
angiotensin ii Giapreza: injectable form of angiotensin II used to increase blood pressure in adult patients with septic or other distributive shock. Ile(5)-angiotensin II : An angiotensin II that acts on the central nervous system (PDB entry: 1N9V).	2.11	1	amino acid zwitterion; angiotensin II	human metabolite
n-phenylacrylamide N-phenylacrylamide: structure in first source	2.13	1
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.13	1	cyclodextrin
7-methoxyflavone 7-methoxyflavone: an aromatase inhibitor	2.05	1	ether; flavonoids
m antigen, brucella melitensis M antigen, Brucella melitensis: preparation of soluble antigen of Brucella melitensis; Brucella melitensis M antigen	2.11	1
sepharose agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.	2.78	3
4'-diethylamino-3-hydroxyflavone 4'-diethylamino-3-hydroxyflavone: an extrinsic multiple-emission probe; structure in first source	2.05	1
melitten Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.	2.07	1
chitosan [no description available]	7.41	1
methylcellulose Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.	7.13	1
angiotensin i Angiotensin I: A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.. angiotensin I : A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.. angiotensin I dizwitterion : A peptide zwitterion that is the dizwitterionic form of angiotensin I having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3.	2.11	1	angiotensin; peptide zwitterion	human metabolite; neurotransmitter agent
lactoferrin Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.	2.48	2

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.11	1	0
Arteriovenous Malformations Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.	0	2.05	1	0

tert-butylacrylamide

Description

Cross-References

Synonyms (48)

Research Excerpts

Dosage Studied

Protein Targets (3)

Potency Measurements

Research

Studies (24)

Market Indicators

Research Demand Index: 34.00

Study Types