solasulfone profile

Solasulfone, also known as dapsone, is a sulfone antibiotic used to treat leprosy and other infections. It is synthesized through a multi-step process involving the reaction of aniline with chlorosulfonic acid to form sulfanilic acid, followed by a series of reactions to introduce the sulfone group. Solasulfone exerts its therapeutic effect by inhibiting the synthesis of dihydrofolate reductase, an enzyme essential for bacterial growth. It is particularly effective against Mycobacterium leprae, the causative agent of leprosy. Solasulfone has been studied extensively for its potential applications in treating various infectious diseases, including malaria, toxoplasmosis, and Pneumocystis pneumonia. Its long history of use and effectiveness in treating leprosy make it a valuable therapeutic agent. However, concerns regarding adverse effects, such as hemolysis in individuals with glucose-6-phosphate dehydrogenase deficiency, have prompted researchers to investigate alternative treatment options.'

solasulfone: used in drug therapy of leprosy; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	8626
CHEMBL ID	2106031
MeSH ID	M0054811

Synonym
phenopryldiasulfone sodique
solapsone [dcit]
einecs 205-116-7
solasulfonum [inn-latin]
tetrasodium salt of 1,1'-(sulfonylbis(p-phenylimino))bis-(3-phenyl-1,3-propanedisulfonic acid)
sulfetrone
solasulfona [inn-spanish]
4,4'-diamino-diphenyl-sulfon-di-(3-phenyl-propan-1,3-disulfonat)natrium (1:4) [german]
solasulfone
1,3-propanedisulfonic acid, 1,1'-(sulfonylbis(p-phenyleneimino))bis(3-phenyl-, tetrasodium salt
solasulfone [inn]
133-65-3
phenopryldiasulfone sodium
CHEMBL2106031
solasulphone
unii-h12je4313s
h12je4313s ,
solasulfona
solasulfonum
4,4'-diamino-diphenyl-sulfon-di-(3-phenyl-propan-1,3-disulfonat)natrium (1:4)
solapsone
solapsone [mart.]
solasulfone [mi]
tetrasodium salt of 1,1'-(sulfonylbis(p-phenylimino)bis-(3-phenyl-1,3-propanedisulfonic acid)
solasulfon
DTXSID50927894
tetrasodium;1-phenyl-3-[4-[4-[(3-phenyl-1,3-disulfonatopropyl)amino]phenyl]sulfonylanilino]propane-1,3-disulfonate
Q7557110
sodium 3,3'-((sulfonylbis(4,1-phenylene))bis(azanediyl))bis(1-phenylpropane-1,3-disulfonate)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	30 (93.75)	18.7374
1990's	1 (3.13)	18.2507
2000's	1 (3.13)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	40 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dapsone [no description available]	3.32	7	substituted aniline; sulfone	anti-inflammatory drug; antiinfective agent; antimalarial; leprostatic drug
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	1.93	1	carbohydrazide	antitubercular agent; drug allergen
aminosalicylic acid Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.. 4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.	2.33	2	aminobenzoic acid; phenols	antitubercular agent
sulfanilamide [no description available]	1.92	1	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
sulfoxone sulfoxone: RN given refers to parent cpd	2.62	3	sulfonamide
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	2	1	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
streptomycin [no description available]	2.62	3	antibiotic antifungal drug; antibiotic fungicide; streptomycins	antibacterial drug; antifungal agrochemical; antimicrobial agent; antimicrobial drug; bacterial metabolite; protein synthesis inhibitor
cefazolin Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.	1.97	1	beta-lactam antibiotic allergen; cephalosporin; tetrazoles; thiadiazoles	antibacterial drug
glucosulfone glucosulfone: RN given refers to parent cpd; synonym promin refers to di-Na salt	1.92	1	sulfonamide
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	1.92	1	chalcogen; nonmetal atom	macronutrient

Condition	Relationship Strength	Studies
Hansen Disease [description not available]	3.94	14
Leprosy A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.	8.94	14
Koch's Disease [description not available]	3.63	10
Pulmonary Consumption [description not available]	2.62	3
Tuberculosis Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.	3.63	10
Tuberculosis, Pulmonary MYCOBACTERIUM infections of the lung.	2.62	3
Fibroid [description not available]	1.93	1
Cancer of Skin [description not available]	1.93	1
Leiomyoma A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.	1.93	1
Skin Neoplasms Tumors or cancer of the SKIN.	1.93	1
Pachymeningitis [description not available]	1.92	1
Meningitis, Tuberculous [description not available]	1.92	1
Meningitis Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)	1.92	1
Tuberculosis, Meningeal A form of bacterial meningitis caused by MYCOBACTERIUM TUBERCULOSIS or rarely MYCOBACTERIUM BOVIS. The organism seeds the meninges and forms microtuberculomas which subsequently rupture. The clinical course tends to be subacute, with progressions occurring over a period of several days or longer. Headache and meningeal irritation may be followed by SEIZURES, cranial neuropathies, focal neurologic deficits, somnolence, and eventually COMA. The illness may occur in immunocompetent individuals or as an OPPORTUNISTIC INFECTION in the ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunodeficiency syndromes. (From Adams et al., Principles of Neurology, 6th ed, pp717-9)	1.92	1
Infection, Toxoplasma gondii [description not available]	1.93	1
Toxoplasmosis The acquired form of infection by Toxoplasma gondii in animals and man.	1.93	1
Great Pox [description not available]	1.97	1
Chancre The primary sore of syphilis, a painless indurated, eroded papule, occurring at the site of entry of the infection.	1.97	1
Syphilis A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.	1.97	1
Recrudescence [description not available]	1.96	1

solasulfone

Description

Cross-References

Synonyms (29)

Research

Studies (32)

Market Indicators

Research Demand Index: 10.55

Study Types