Page last updated: 2024-12-08
ici 147798
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
ICI 147798: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 134361 |
| SCHEMBL ID | 11175828 |
| MeSH ID | M0152061 |
Synonyms (15)
| Synonym |
|---|
| pyrazinecarboxamide, 3,5-diamino-6-chloro-n-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)- |
| jct2l02hhb , |
| unii-jct2l02hhb |
| 3,5-diamino-6-chloro-n-(1-n-(2-hydroxyl-3-naphthoxypropylamino)ethylcarbamoyl)-1-methylethylpyrazine-2-carboxamide |
| ici-147798 |
| ici 147798 |
| 83812-65-1 |
| 3,5-diamino-6-chloro-n-[1-[2-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]ethylamino]-2-methyl-1-oxopropan-2-yl]pyrazine-2-carboxamide |
| SCHEMBL11175828 |
| 3,5-diamino-6-chloro-n-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)-2-pyrazinecarboxamide |
| 2-pyrazinecarboxamide, 3,5-diamino-6-chloro-n-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)- |
| (+/-)-ici-147798 |
| DTXSID601003885 |
| 3,5-diamino-6-chloro-n-(1-hydroxy-1-{[2-({2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl}amino)ethyl]imino}-2-methylpropan-2-yl)pyrazine-2-carboximidic acid |
| PD159773 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " ICI 147,798 produced a dose-dependent shift to the right of the dose-response (chronotropic) curve of isoproterenol with suppression of the maximal tachycardia, an effect characteristic of insurmountable beta receptor blockade." | ( Insurmountable beta receptor blockade by ICI 147,798 in rabbits. Giles, RE; Hwang, TF; Kau, ST; Keith, RA; Murthy, VS; Salama, AI; Wurm, R; Zagar, ME, 1989) | 0.28 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.32
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.32) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||