veratrilogenin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

veratrilogenin: from roots of Veratrilla baillinii Franch.; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Veratrilla	genus	[no description available]	Gentianaceae	A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.[MeSH]

Cross-References

ID Source	ID
PubMed CID	5490798
CHEMBL ID	4100829
MeSH ID	M0098183

Synonyms (8)

Synonym
veratrilogenin
1,7-dihydroxy-3,4-dimethoxyxanthen-9-one
1,7-dihydroxy-3,4-dimethoxy-xanthone
9h-xanthen-9-one, 1,7-dihydroxy-3,4-dimethoxy-
76907-77-2
1,7-dihydroxy-3,4-dimethoxyxanthone
DTXSID70227707
CHEMBL4100829

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID1434700	Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3	Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
AID1434698	Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3	Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
AID1434699	Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay	2017	Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3	Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.53 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	1.95	1	xanthene
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.15	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
euxanthone euxanthone : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.	2.15	1	phenols; xanthones	metabolite; plant metabolite
gentisein gentisein: isolated from the methanol extract of the herb of Hypericum annulatum; structure in first source. gentisein : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3 and 7.	2.15	1	polyphenol; xanthones	plant metabolite
gentisin gentisin: a hydroxyxanthone from methanol extract of Gentianae (Gentian?) radix and Calophyllum. gentisin : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1 and 7 and a methoxy group at position 3.	2.15	1	aromatic ether; polyphenol; xanthones	plant metabolite
1,7-dihydroxy-4-methoxyxanthone 1,7-dihydroxy-4-methoxyxanthone : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy groups at positions 1 and 7, a methoxy group at position 4 and an oxo group at position 9. It has been isolated from the stems of Cratoxylum cochinchinense.	2.15	1	aromatic ether; phenols; xanthones	metabolite; plant metabolite

Condition	Relationship Strength	Studies
Innate Inflammatory Response [description not available]	2.25	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.25	1
Rheumatoid Arthritis [description not available]	2.11	1
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	2.11	1

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