drosopterin

Description

drosopterin: eye pigments of Drosophila melanogaster; RN given refers to (trans)-(+-)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135618521
MeSH ID	M0073914

Synonyms (6)

Synonym
drosopterin
33466-46-5
(z)-(+)-2-amino-6-(1-(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)-3-hydroxy-2-oxopropylidene)-5,6,7,8-tetrahydro-4(1h)-pteridinone
drosopterins
DTXSID90955095
3,10-diimino-14-methyl-3,5,6,6a,6b,7,9,10-octahydro-4h-pyrimido[4'',5'':2',3'][1,4]diazepino[6',5':3,4]pyrrolo[1,2-f]pteridine-1,12-diol

Dosage Studied

Excerpt	Reference
" Although there may be other molecular differences between the heterochromatic regions of the recombinants, the most obvious is the dosage of NO."	( Nucleolus organizer-suppressed position-effect variegation in Drosophila melanogaster. DeSalle, R; Spofford, JB, 1991)
" The extent of rescue was dependent on the dosage of transgenic CG6781."	( Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases. Ahn, C; Kim, J; Kim, K; Kim, S; Suh, H; Yim, J, 2006)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (43.48)	18.7374
1990's	4 (17.39)	18.2507
2000's	6 (26.09)	29.6817
2010's	3 (13.04)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (8.70%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (91.30%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pteridines [no description available]	6.07	23	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; pteridines
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	1.96	1	alkanethiol; primary alcohol	geroprotector
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	1.94	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	2.05	1	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	1.97	1	xanthene
xanthommatin [no description available]	1.97	1	xanthommatins
riboflavin vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).	2.17	1	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite
astaxanthine astaxanthine: a keto form of carotene; pigment in flesh of Scottish salmon (Salmo salar) crustacoa-lobster (Homarus gammarus, flamingo feathers; structure; a carotenoid without vitamin A activity, has shown anti-oxidant and anti-inflammatory activities. astaxanthin : A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein.	2.17	1	carotenol; carotenone	animal metabolite; anticoagulant; antioxidant; food colouring; plant metabolite
sepiapterin sepiapterin: A substrate of sepiapterin reductase	1.94	1	sepiapterin
dihydroneopterin triphosphate [no description available]	2.37	2	dihydropterin; neopterins; pterin phosphate	Escherichia coli metabolite; mouse metabolite
2-amino-4-oxo-6-acetyl-7,8-dihydro-3h,9h-pyrimidodiazepine 2-amino-4-oxo-6-acetyl-7,8-dihydro-3H,9H-pyrimidodiazepine: a 6-acetylpyrimidodiazepine intermediate in biosyn of drosopterin. 6-acetyl-2-amino-3,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-4-one : A member of the class of pyrimidodiazepine 3,7,8,9-tetrahydropyrimido[4,5-b][1,4]diazepin-4-one bearing amino and acetyl substituents at positions 2 and 6 respectively.	2.87	4	methyl ketone; pyrimidodiazepine	metabolite
neopterin [no description available]	2.37	2
7,8-dihydropterin 7,8-dihydropterin: RN given refers to parent cpd	1.95	1	organic molecular entity; pterins

Condition	Indicated	Relationship Strength	Studies	Trials
Chromosome Inversion An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.	0	1.97	1	0

chemdatabank.com