Page last updated: 2024-11-13

bam 12p

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

BAM 12P: Pro-Met-enkephalin precursor; isolated from bovine adrenal medulla; dodecapeptide Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	25077551
MeSH ID	M0087597

Synonyms (15)

Synonym
6,7-arg-8-val-9-gly-10-arg-11-pro-12-glu-met-enkephalin
bam-12p
75513-71-2
l-glutamic acid, n-(1-(n(2)-(n-(n-(n(2)-(n(2)-(n-(n-(n-(n-l-tyrosylglycyl)glycyl)-l-phenylalanyl)-l-methionyl)-l-arginyl)-l-arginyl)-l-valyl)glycyl)-l-arginyl)-l-prolyl)-
methionine-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-
bam 12p
enkephalin-met, arginyl(6,7)-valyl(8)-glycyl(9)-arginyl(10)-prolyl(11)-glu(12)-
enkephalin-met, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-
met-enkephalin, arg(6,7)-val(8)-gly(9)-arg(10)-pro(11)-glu(12)-
bam-12p (h-l-tyr-gly-gly-l-phe-l-met-l-arg-l-arg-l-val-gly-l-arg-l-pro-l-glu-oh)
mfcd00076689
EX-A7440
bam12p
(2s)-2-[[(2s)-1-[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)- 2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl] amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoyl] amino]-5-(diaminomethylideneamino)pentanoyl]
AKOS040744571

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (78.57)	18.7374
1990's	3 (21.43)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.48 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.31 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.48)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	1.97	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	1.99	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	1.97	1	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
enkephalin, methionine Enkephalin, Methionine: One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.	3.98	14
enkephalin-met, arg(6)-phe(7)- [no description available]	3.06	5	organic molecular entity
enkephalin-met, arg(6)-gly(7)-leu(8)- enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-: from bovine adrenal medulla; has 35% the opiate receptor binding activity of Met-enkephalin	2.65	3
bradykinin [no description available]	1.96	1	oligopeptide	human blood serum metabolite; vasodilator agent
enkephalin, leucine Enkephalin, Leucine: One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.. Leu-enkephalin : A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.	3.67	10	pentapeptide; peptide zwitterion	analgesic; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist; neurotransmitter; rat metabolite
adrenorphin adrenorphin: opioid octapeptide from human & bovine adrenal medulla & human phaeochromocytoma tumor; H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2	2.37	2
dynorphins Dynorphins: A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.	1.99	1
peptide f peptide F: pro-enkephalin intermediate	2.66	3
bam 22p [no description available]	3.22	6
peptide e (adrenal medulla) peptide E (adrenal medulla): kappa opiate receptor agonist; 25-amino acid opioid peptide which when cleaved at the sole double basic (Lys-Arg) typical processing site generates the amino-terminal fragment BAM 18 & the carboxy-terminal fragment Leu-enkephalin; structure given in first source;	2.88	4
bam 18p BAM 18P: opioid peptide derived form proenkephalin A	1.97	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	1.99	1	benzenes; hydroxycoumarin; methyl ketone
preproenkephalin preproenkephalin: initial enkephalin precursor	1.96	1

Condition	Indicated	Relationship Strength	Studies	Trials
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	0	2.37	2	0

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