4-chlorocinnamic acid : An organochlorine compound comprising trans-cinnamic acid having a chloro substituent at the 4-position on the phenyl ring. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 637797 |
| CHEMBL ID | 327951 |
| CHEBI ID | 61116 |
| Synonym |
|---|
| CHEMBL327951 , |
| chebi:61116 , |
| LS-13584 |
| (2e)-3-(4-chlorophenyl)acrylic acid |
| nsc-1509 |
| cinnamic acid, p-chloro- |
| 2-propenoic acid, 3-(4-chlorophenyl)- |
| nsc1509 |
| 3-(p-chlorophenyl)acrylic acid |
| 4-chlorocinnamic acid |
| 1615-02-7 |
| nsc-2756 |
| wln: qv1u1r dg |
| p-chlorocinnamic acid |
| nsc2756 |
| trans-p-chlorocinnamic acid |
| nsc52172 |
| 940-62-5 |
| nsc-52172 |
| p-chloro-trans-cinnamic acid |
| (e)-p-chlorocinnamic acid |
| ai3-16650 |
| nsc 2756 |
| ccris 3779 |
| einecs 216-564-8 |
| 3-(4-chlorophenyl)-2-propenoic acid |
| nsc 1509 |
| IDI1_030035 |
| inchi=1/c9h7clo2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6h,(h,11,12)/b6-3 |
| 4-chlorocinnamic acid, 99% |
| STK065389 |
| (2e)-3-(4-chlorophenyl)prop-2-enoic acid |
| AC-10322 |
| HMS1513H03 |
| (e)-3-(4-chlorophenyl)prop-2-enoic acid |
| AKOS000119901 |
| A810264 |
| (e)-3-(4-chlorophenyl)prop-2-enoate;4-chlorocinnamic acid |
| 3-(4-chlorophenyl)acrylic acid |
| trans-4-chlorocinnamic acid |
| trans-3-(4-chlorophenyl)propenoic acid |
| cinnamic acid, p-chloro-, (e)- |
| nsc 52172 |
| 2-propenoic acid, 3-(4-chlorophenyl)-, (e)- |
| einecs 213-373-1 |
| cinnamic acid, p-chloro-, trans- |
| 4-chlorocinnamic acid, predominantly trans |
| 2-propenoic acid, 3-(4-chlorophenyl)-, (2e)- |
| (e)-3-(4-chlorophenyl)acrylic acid |
| AE-641/01605057 |
| S12285 |
| AB00443734-03 |
| trans-3-(4-chloro-phenyl)-acrylic acid |
| 4-chloro-trans-cinnamic acid |
| (e)-3-(4-chloro-phenyl)-acrylic acid |
| p-chloro cinnamic acid |
| e-3-(4-chlorophenyl)propenoic acid |
| MS-9830 |
| W-107972 |
| (2e)-3-(4-chlorophenyl)-2-propenoic acid # |
| mfcd00004396 |
| F0850-6846 |
| sr-01000597225 |
| SR-01000597225-1 |
| bdbm50486901 |
| 4-chlorocinnamicacid |
| Z56989206 |
| BCP21408 |
| Q27130822 |
| 3-(4-chlorophenyl)acrylicacid |
| EN300-17694 |
| EN300-364934 |
| BBL036957 |
| AMY3852 |
| A922539 |
| NCGC00342159-01 |
| CS-0015730 |
| (2e)-3-(4-chlorophenyl)-2-propenoic acid |
| DTXSID001275521 |
| HY-Y0729 |
| Class | Description |
|---|---|
| monochlorobenzenes | Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1755149 | Larvicidal activity against Aedes aegypti 4th instar larvae measured after 48 hrs | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID1755151 | Drug recovery in Aedes aegypti larval extract by HPLC analysis | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID1755152 | Drug recovery in Aedes aegypti supernatant measured after 24 hrs by HPLC analysis | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID1755150 | Retention time of the compound | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID1755148 | Larvicidal activity against Aedes aegypti assessed as mortality at 100 ug/ml measured after 24 hrs relative to control | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID594382 | Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells at 10 uM by liquid scintillation counting | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9 | Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). |
| AID1755147 | Larvicidal activity against Aedes aegypti assessed as mortality at 45 ug/ml measured after 24 hrs relative to control | 2021 | Bioorganic & medicinal chemistry, 08-15, Volume: 44 | Larvicidal activity and in silico studies of cinnamic acid derivatives against Aedes aegypti (Diptera: Culicidae). |
| AID37266 | Inhibition of alpha-glucosidase activity | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11 | Structure-activity relationships of trans-cinnamic acid derivatives on alpha-glucosidase inhibition. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (27.55) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||