Compounds > furanacrylic acid
Page last updated: 2024-11-08

furanacrylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID643402
CHEMBL ID1771761
SCHEMBL ID125125
MeSH IDM0073952

Synonyms (85)

Synonym
BB 0238505
(e)-3-furan-2-yl-acrylic acid
2-propenoic acid, 3-(2-furanyl)-
furacrylic acid
furylacrylic acid ,
furanacrylic acid
539-47-9
nsc4671
(2-furyl)acrylic acid
acrylic acid, .beta.-2-furyl-
nsc-4671
2-furanacrylic acid
3-(2-furyl)acrylic acid
2-furalacetic acid
.beta.-(2-furyl)acrylic acid
furfurylideneacetic acid
nsc-32626
nsc32626
acrylic acid, beta-2-furyl-
3-(2-furyl)propenoic acid
ai3-03662
3-(2-furanyl)-2-propenoic acid
nsc 32626
einecs 208-718-8
nsc74521
2-furanacrylic acid, (e)-
nsc-74521
trans-2-furanacrylic acid
15690-24-1
inchi=1/c7h6o3/c8-7(9)4-3-6-2-1-5-10-6/h1-5h,(h,8,9)/b4-3
3-(2-furyl)acrylic acid, 99%
(2e)-3-(furan-2-yl)prop-2-enoic acid
STK073622
AKOS000111373
HMS1648L01
3-(furan-2-yl)prop-2-enoic acid
furan-2-acrylic acid
furfurylidene acetic acid
(e)-3-(furan-2-yl)prop-2-enoic acid
F0084
CHEMBL1771761 ,
nsc 74521
trans-3-(2-furanyl)-2-propenoic acid
trans-beta-2-furylacrylic acid
unii-m2u24oa3uj
m2u24oa3uj ,
(e)-3-(2-furyl)-2-propenoic acid
trans-3-(furan-2-yl)acrylic acid
bdbm50342413
(e)-3-(furan-2-yl)-acrylic acid
(e)-3-(furan-2-yl)acrylic acid
3-fur-2-ylacrylic acid
2-propenoic acid, 3-(2-furanyl)-, (e)-
AM20100325
AB00375883-02
BBL023478
BP-30101
e-3-(2-furyl)propenoic acid
(2e)-3-(2-furyl)acrylic acid
(2e)-3-furan-2-ylprop-2-enoic acid
3-(furan-2-yl)acrylic acid
SCHEMBL125125
2-furanacrylic acid [mi]
2-propenoic acid, 3-(2-furanyl)-, (2e)-
.beta.-2-furylacrylic acid
(e)-3-(2-furyl)prop-2-enoic acid
3-(2-furyl)-2-propenoic acid #
J-640036
J-650062
BS-3783
2-propenoic acid,3-(2-furanyl)-,(2e)-
F3145-0221
3-(2-furyl)acroleine
J-800038
(e)-3-(furan-2-yl)acrylicacid
CS-W013327
(2e)(c)\\3(c)\\(furan(c)\\2(c)\\yl)prop(c)\\2(c)\\enoic acid
EN300-18145
(e)-2-furanacrylic acid
Q27283406
P20225
DTXSID50901230
EN300-304620
(2e)-3-(2-furanyl)-2-propenoic acid
Z2311574202
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Hydroxycarboxylic acid receptor 2Homo sapiens (human)Ki8.10000.00401.49308.1000AID594381
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
neutrophil apoptotic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
positive regulation of neutrophil apoptotic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
negative regulation of lipid catabolic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
positive regulation of adiponectin secretionHydroxycarboxylic acid receptor 2Homo sapiens (human)
G protein-coupled receptor signaling pathwayHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
nicotinic acid receptor activityHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
plasma membraneHydroxycarboxylic acid receptor 2Homo sapiens (human)
cell junctionHydroxycarboxylic acid receptor 2Homo sapiens (human)
plasma membraneHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID594381Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting2011Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9610halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
furan
furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.		6.9310furans;
mancude organic heteromonocyclic parent;
monocyclic heteroarene		carcinogenic agent;
hepatotoxic agent;
Maillard reaction product
senecioic acid
senecioic acid: structure. 3-methylbut-2-enoic acid : A methyl-branched fatty acid that is but-2-enoic acid bearing a methyl substituent at position 3.		2.0610alpha,beta-unsaturated monocarboxylic acid;
methyl-branched fatty acid;
monounsaturated fatty acid;
short-chain fatty acid		plant metabolite
bradykinin
[no description available]		2.3620oligopeptidehuman blood serum metabolite;
vasodilator agent
e-z cinnamic acid
cinnamic acid : A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.. trans-cinnamic acid : The E (trans) isomer of cinnamic acid		2.0610cinnamic acidplant metabolite
fumaric acid
fumaric acid: see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters. fumaric acid : A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.		2.0610butenedioic acidfood acidity regulator;
fundamental metabolite;
geroprotector
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.0610ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
crotonic acid
crotonic acid: a stereospecific unsaturated carboxylic acid found in CROTON OIL. butenoic acid : Any C4, straight-chain fatty acid containing one double bond.. crotonic acid : A but-2-enoic acid with a trans- double bond at C-2. It has been isolated from Daucus carota.		2.06102-butenoic acidplant metabolite
2-hydroxycinnamic acid
trans-2-coumaric acid : The trans-isomer of 2-coumaric acid.. 2-coumaric acid : A monohydroxycinnamic acid in which the hydroxy substituent is located at C-2 of the phenyl ring.		2.06102-coumaric acid;
phenols		antioxidant;
metabolite
3-coumaric acid
3-coumaric acid: RN given refers to cpd without isomeric designation in Chemline. trans-3-coumaric acid : A 3-coumaric acid that is phenol substituted with trans-2-propenoic acid at position C-3.. 3-coumaric acid : A monohydroxycinnamic acid in which the hydroxy substituent is located at C-3 of the phenyl ring.		2.06103-coumaric acid
trans-4-coumaric acid
hydroxycinnamic acid : Any member of the class of cinnamic acids carrying one or more hydroxy substituents.. trans-4-coumaric acid : The trans-isomer of 4-coumaric acid.. 4-coumaric acid : A coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring.		2.06104-coumaric acidfood component;
mouse metabolite;
plant metabolite
4-chlorocinnamic acid
4-chlorocinnamic acid : An organochlorine compound comprising trans-cinnamic acid having a chloro substituent at the 4-position on the phenyl ring.		2.0610monochlorobenzenes
Methylenedioxycinnamic acid
[no description available]		2.0610hydroxycinnamic acid
caffeic acid
trans-caffeic acid : The trans-isomer of caffeic acid.		2.0610caffeic acidgeroprotector;
mouse metabolite
4-methoxycinnamic acid
[no description available]		2.0610cinnamic acids
ethyl fumarate
[no description available]		2.0610
monomethyl fumarate
monomethyl fumarate : A dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol. Is is a metabolite of dimethyl fumarate and used for the the treatment of patients with relapsing multiple sclerosis (MS). It also induces the NFE2L2 (Nrf2) transcription factor by binding to KEAP1.		2.0610dicarboxylic acid monoester;
enoate ester;
methyl ester		antioxidant;
drug metabolite;
immunomodulator
angiotensin i
Angiotensin I: A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME.. angiotensin I : A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.. angiotensin I dizwitterion : A peptide zwitterion that is the dizwitterionic form of angiotensin I having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3.		2.3620angiotensin;
peptide zwitterion		human metabolite;
neurotransmitter agent
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610