| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1797909 | Enzyme Inhibition Assay and Whole Cell Enzyme Occupancy Assay from Article 10.1021/jm0504961: \\Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.\\ | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID1797910 | Enzyme Inhibition Assay and Bone Resorption Assay from Article 10.1021/jm0504961: \\Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.\\ | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID1797908 | Enzyme Inhibition Assay from Article 10.1021/jm0504961: \\Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.\\ | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257094 | Inhibitory activity against mouse cathepsin S | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256990 | Terminal half-life in rat | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257085 | Inhibitory activity against human cathepsin B expressed in HepG2 cells | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID254762 | Inhibitory activity against cathepsin S from human | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. |
| AID256977 | Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257088 | Inhibitory activity against human cathepsin S | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256976 | Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrate | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID256992 | Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257100 | Effect of compound on antigen presentation in mouse A20 cells transfected with PC-specific mIgM by IL-2 secretion | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256978 | Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID254886 | Inhibitory activity against cathepsin K using humanized rabbit enzyme | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. |
| AID254760 | Inhibitory activity against cathepsin B from human | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. |
| AID257084 | Inhibitory activity against human cathepsin B | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257096 | Volume of distribution in rat administered with 10 mg/kg, po | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256991 | Reduction of collagen breakdown products in ovariectomized rhesus monkey dosed at 15, 3 and 0.6 mg/kg, po | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID256985 | Oral bioavailability in rat | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257086 | Inhibitory activity against human cathepsin L | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257090 | Partition co-efficient, logP of the compound | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257092 | Inhibitory activity against rabbit cathepsin K | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID254761 | Inhibitory activity against cathepsin L from human | 2005 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 15, Issue:21
| Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. |
| AID256975 | Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257083 | Inhibitory activity against humanized rabbit cathepsin K | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256979 | In vitro bone resorption in isolated rabbit osteoclasts | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257095 | Inhibitory activity against mouse cathepsin S in mouse splenocytes | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257087 | Inhibitory activity against human cathepsin L expressed in HepG2 cells | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257091 | Dissociation constant, pKa of the compound | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257098 | Plasma concentration in rat at 10 mg/kg, po | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID257093 | Effect of compound on degradation of collagen in osteoclast bone resorption assay | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| AID256989 | Maximum concentration in rat administered with 20 mg/kg, po | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. |
| AID257089 | Inhibitory activity against human cathepsin S expressed in ramos cells | 2005 | Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24
| Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |