Compounds > 4,4'-dichlorobenzophenone
Page last updated: 2024-12-05

4,4'-dichlorobenzophenone

Description

4,4'-Dichlorobenzophenone is a white, crystalline solid that is used as an intermediate in the synthesis of various chemical compounds, including pharmaceuticals, pesticides, and dyes. Its synthesis typically involves the Friedel-Crafts acylation of chlorobenzene with benzoyl chloride. 4,4'-Dichlorobenzophenone exhibits a wide range of biological activities, including antibacterial, antifungal, and anticancer properties. It is also known to be a photoinitiator, which means it can initiate polymerization reactions when exposed to ultraviolet light. Research on 4,4'-Dichlorobenzophenone focuses on its potential applications in various industries, particularly in the development of new pharmaceuticals and materials. Its diverse biological activities and photoinitiating properties make it a subject of interest for researchers in various fields.

4,4'-dichlorobenzophenone: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7034
CHEMBL ID1870191
CHEBI ID194706
SCHEMBL ID51827
MeSH IDM0045906

Synonyms (67)

Synonym
EN300-31834
p-dichlorobenzophenone
4,4'-dichlorobenzophenone (dbp)
di(4-chlorophenyl)ketone
einecs 202-030-1
nsc 8787
bis(p-chlorophenyl)ketone
benzophenone, 4,4'-dichloro-
ai3-03064
brn 0643345
dbp (van)
bis(4-chlorophenyl)ketone
wln: gr dvr dg
di(p-chlorophenyl)ketone
nsc-8787
nsc8787
p,p'-dichlorobenzophenone
dcbp
bis(4-chlorophenyl) ketone
methanone, bis(4-chlorophenyl)-
usaf do-4
bis(4-chlorophenyl)methanone
4,4'-dichlorobenzophenone
C06643
90-98-2
STK290986
4,4'-dichlorobenzophenone, 99%
NCGC00163933-01
AC-10278
AKOS000282714
BMSE000517
D1621
CHEBI:194706
4-4-dichlorobenzophenone
cas-90-98-2
dtxsid3037626 ,
tox21_302130
dtxcid1017626
NCGC00255637-01
bis(4-chlorophenyl)-methanone
4,4'-dbp
unii-3mtl0yc2q5
3mtl0yc2q5 ,
4-07-00-01376 (beilstein handbook reference)
FT-0617037
4,4-dichlorobenzophenone
AE-641/00433006
SCHEMBL51827
4,4'-dichloro-benzophenone
bis-(4-chloro-phenyl)-methanone
p,p-dichlorobenzophenone
bis(4-chlorophenyl)methanone #
W-100319
CHEMBL1870191
mfcd00000623
4,4;-dichlorobenzophenone
4,4 inverted exclamation mark -dichlorobenzophenone
4,4'-dichlorobenzophenone, purum, >=99.0% (gc)
4,4'-dbp, pestanal(r), analytical standard
4,4'-dichlorobenzophenone 10 microg/ml in cyclohexane
SY009660
Q4637048
4,4'-dichlorobenzophenone-d8
AS-11851
CS-W012634
HY-W011918
Z335453234
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzophenonesAny aromatic ketone in which the carbonyl group is bonded to 2 phenyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency47.28120.001022.650876.6163AID1224838; AID1224893
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency39.40960.003041.611522,387.1992AID1159552; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency64.27640.001530.607315,848.9004AID1224841; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency21.68990.005428.02631,258.9301AID1346982
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.00280.010039.53711,122.0200AID588547
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (27.27)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.30

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.30 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.19 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.30)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hexachlorocyclohexane
Lindane: An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. It has been used as a pediculicide and scabicide, and shown to cause cancer.. beta-hexachlorocyclohexane : The beta-isomer of hexachlorocyclohexane.		210chlorocyclohexane
theophylline
[no description available]		1.9510dimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
dichlorodiphenyl dichloroethylene
Dichlorodiphenyl Dichloroethylene: An organochlorine pesticide, it is the ethylene metabolite of DDT.		1.9610chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt
1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source		8.2560benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
dichlorodiphenyldichloroethane
Dichlorodiphenyldichloroethane: An organochlorine insecticide that is slightly irritating to the skin. (From Merck Index, 11th ed, p482)		2.3720chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
bis(p-chlorophenyl)acetic acid
bis(p-chlorophenyl)acetic acid: a metabolite of DDT; RN given refers to parent cpd.. bis(4-chlorophenyl)acetic acid : A organochlorine compound comprising acetic acid having two 4-chlorophenyl substituents attached at the 2-position.		1.9510monocarboxylic acid;
monochlorobenzenes
tetrahydrophthalimide
tetrahydrophthalimide: captan metabolite in fruit crops		2.1710
phthalimide
phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.		2.1710phthalimides
dicofol
Dicofol: An organochlorine insecticide.. dicofol : A tertiary alcohol that is DDT in which the benzylic hydrogen has been replaced by a hydroxy group.		3.1250monochlorobenzenes;
organochlorine acaricide;
tertiary alcohol
captan
Captan: One of the phthalimide fungicides.. captan : A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops.		2.1710isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		210cadmium molecular entity;
zinc group element atom
dieldrin
Dieldrin: An organochlorine insecticide whose use has been cancelled or suspended in the United States. It has been used to control locusts, tropical disease vectors, in termite control by direct soil injection, and non-food seed and plant treatment. (From HSDB). dieldrin : An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin.		210epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		210carbon group element atom;
elemental lead;
metal atom		neurotoxin
ConditionIndicatedRelationship StrengthStudiesTrials
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