Compounds > sk&f 94482
Page last updated: 2024-09-25

sk&f 94482

Cross-References

ID SourceID
PubMed CID135156
CHEMBL ID4643501
SCHEMBL ID4607536
MeSH IDM0149174

Synonyms (20)

Synonym
86134-80-7
8v3s9m26de ,
sk&f 94482
skf 94482
3-cyclobutene-1,2-dione, 3-amino-4-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)-
unii-8v3s9m26de
skf-94482
bmy-25368
bmy 25368
3-amino-4-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]cyclobut-3-ene-1,2-dione
1-[3-[3-(piperidinomethyl)phenoxy]prop-1-ylamino]-2-amino-cyclobut-1-ene-3,4-dione
KSBYXRUNSLGUNE-UHFFFAOYSA-N ,
1-amino-2-[3-(3-piperidinomethylphenoxy)propylamino]-1-cyclobutene-3,4-dione
SCHEMBL4607536
DTXSID50235421
3-amino-4-((3-(3-(1-piperidinylmethyl)phenoxy)propyl)amino)-3-cyclobutene-1,2-dione
bdbm50543289
CHEMBL4643501 ,
PD161090
AKOS040745620

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histamine H2 receptorHomo sapiens (human)Ki0.01590.00062.197310.0000AID1661712
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
gastric acid secretionHistamine H2 receptorHomo sapiens (human)
immune responseHistamine H2 receptorHomo sapiens (human)
positive regulation of vasoconstrictionHistamine H2 receptorHomo sapiens (human)
G protein-coupled serotonin receptor signaling pathwayHistamine H2 receptorHomo sapiens (human)
chemical synaptic transmissionHistamine H2 receptorHomo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerHistamine H2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
histamine receptor activityHistamine H2 receptorHomo sapiens (human)
G protein-coupled serotonin receptor activityHistamine H2 receptorHomo sapiens (human)
neurotransmitter receptor activityHistamine H2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
plasma membraneHistamine H2 receptorHomo sapiens (human)
synapseHistamine H2 receptorHomo sapiens (human)
plasma membraneHistamine H2 receptorHomo sapiens (human)
dendriteHistamine H2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1661706Antagonist activity at Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins in presence of histamine by GTPgammaS binding assay2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Fluorescent H
AID1661712Binding affinity to human H2R expressing Sf9 cells incubated for 60 mins by microbeta scintillation counter method2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Fluorescent H
AID1661708Selectivity index, ratio of Ki for human H3R expressed in baculovirus infected Sf9 cells to Ki for Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells2020ACS medicinal chemistry letters, Aug-13, Volume: 11, Issue:8
Fluorescent H
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (37.50%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (62.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
histamine[no description available]medium10aralkylamino compound;
imidazoles		human metabolite;
mouse metabolite;
neurotransmitter
piperidines[no description available]medium73
propionic acid[no description available]medium10saturated fatty acid;
short-chain fatty acid		antifungal drug
phenolsulfonphthalein[no description available]medium102,1-benzoxathiole;
arenesulfonate ester;
phenols;
sultone		acid-base indicator;
diagnostic agent;
two-colour indicator
gastrins[no description available]medium11
ranitidine[no description available]medium10C-nitro compound;
furans;
organic sulfide;
tertiary amino compound		anti-ulcer drug;
drug allergen;
environmental contaminant;
H2-receptor antagonist;
xenobiotic
pentagastrin[no description available]medium10organic molecular entity
aspirin[no description available]medium10benzoic acids;
phenyl acetates;
salicylates		anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
chlorpheniramine[no description available]medium10monochlorobenzenes;
pyridines;
tertiary amino compound		anti-allergic agent;
antidepressant;
antipruritic drug;
H1-receptor antagonist;
histamine antagonist;
serotonin uptake inhibitor
cimetidine[no description available]medium10aliphatic sulfide;
guanidines;
imidazoles;
nitrile		adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor
impromidine[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Gastric Ulcer0low10
Stomach Ulcer0low10

Research Highlights

Dosage (4)

ArticleYear
The effect of SK&F 94482 (BMY-25368) on 24-hour intragastric acidity and plasma gastrin concentration in healthy subjects.
Alimentary pharmacology & therapeutics, Volume: 3, Issue: 6		1989
Do H2 receptor antagonists have to be given at night? A study of the antisecretory profile of SKF 94482, a new H2 receptor antagonist which has a profound effect on daytime acidity.
Gut, Volume: 30, Issue: 5		1989
Is the time of dosing of a potent long-acting H2-receptor antagonist critical? Twenty-four-hour pH measurements with SKF-94482.
Scandinavian journal of gastroenterology, Volume: 26, Issue: 5		1991
Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.
American journal of veterinary research, Volume: 52, Issue: 1		1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]