pwz-029 and Down-Syndrome

pwz-029 has been researched along with Down-Syndrome* in 1 studies

Reviews

1 review(s) available for pwz-029 and Down-Syndrome

ArticleYear
Treating enhanced GABAergic inhibition in Down syndrome: use of GABA α5-selective inverse agonists.
    Neuroscience and biobehavioral reviews, 2014, Volume: 46 Pt 2

    Excess inhibition in the brain of individuals carrying an extra copy of chromosome 21 could be responsible for cognitive deficits observed throughout their lives. A change in the excitatory/inhibitory balance in adulthood would alter synaptic plasticity, potentially triggering learning and memory deficits. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mature central nervous system and binds to GABAA receptors, opens a chloride channel, and reduces neuronal excitability. In this review we discuss methods to alleviate neuronal inhibition in a mouse model of Down syndrome, the Ts65Dn mouse, using either an antagonist (pentylenetetrazol) or two different inverse agonists selective for the α5-subunit containing receptor. Both inverse agonists, which reduce inhibitory GABAergic transmission, could rescue learning and memory deficits in Ts65Dn mice. We also discuss safety issues since modulation of the excitatory-inhibitory balance to improve cognition without inducing seizures remains particularly difficult when using GABA antagonists.

    Topics: Animals; Benzodiazepines; Down Syndrome; Drug Inverse Agonism; GABA-A Receptor Antagonists; Humans; Imidazoles; Neural Inhibition; Nootropic Agents; Pentylenetetrazole; Receptors, GABA-A

2014