| Assay ID | Title | Year | Journal | Article |
|---|
| AID230015 | Relative binding affinity for GABA-A receptor alpha-5 over alpha1 subunits | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID349344 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-4-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID72466 | Binding affinity for human GABA-A receptor alpha-1-beta-2-gamma-2 expressed in L(tk-) cell membranes | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID72622 | In vitro binding affinity for human GABA-A receptor alpha-4-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID219954 | Binding affinity against alpha-3-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID110445 | Dose required for 50% seizure of maximum number of animals | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID72917 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID1604600 | Negative allosteric modulation of GABAA alpha5beta3gamma2 (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current response at -60 mV holding potential by two electrode voltage clamp method relative to control | | | |
| AID232720 | Selectivity ratio of alpha1 beta-3 gamma2 GABA A / BzR and alpha5 beta-3 gamma2 GABA A / BzR | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID349341 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-1-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID349346 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-6-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID71548 | In vitro binding affinity for human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID349342 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID73234 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-3-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID71266 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID349345 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-5-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID71268 | Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID73089 | Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID73379 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID72639 | In vitro binding affinity for human GABA-A receptor alpha-6-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID73364 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-4-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID72626 | In vitro binding affinity for human GABA-A receptor alpha-5-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID107612 | Convulsant activity was evaluated | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID73530 | Binding affinity for Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID72476 | Binding affinity for human GABA-A receptor alpha-2-beta-2-gamma-2 expressed in L(tk-) cell membranes | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID349343 | Displacement of [3H]flunitrazepam from human recombinant GABAA alpha-3-beta-3-gamma-2 receptor expressed in HEK293 cells | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID72638 | Binding affinity for human GABA-A receptor alpha-6-beta-2-gamma-2 expressed in L(tk-) cell membranes | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID72621 | In vitro binding affinity for human GABA-A receptor alpha-3-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID219940 | Binding affinity tested against alpha-2-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID72927 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID219795 | It is the ratio of Ki value for alpha-1-beta-3-gamma-2 to that of alpha-5-beta-3-gamma-2 | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID72619 | Binding affinity for human GABA-A receptor alpha-3-beta-2-gamma-2 expressed in L(tk-) cell membranes | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID73244 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID72468 | In vitro binding affinity for human GABA-A receptor alpha-1-beta-3-gamma-2 subunits expressed in L(tk-) cell membranes | 2003 | Journal of medicinal chemistry, Dec-18, Volume: 46, Issue:26
| Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
| AID219794 | Binding affinity against alpha-1-beta-3-gamma-2 GABAA/BzR receptor subtype. | 1998 | Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21
| Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via compar |
| AID73079 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-2-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID73541 | In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-6-beta-3-gamma-2 subunits expressed in L(tk-)cells | 2004 | Bioorganic & medicinal chemistry letters, Mar-22, Volume: 14, Issue:6
| Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
| AID73523 | Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2 | 2000 | Journal of medicinal chemistry, Jan-13, Volume: 43, Issue:1
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
| AID72624 | Binding affinity for human GABA-A receptor alpha-5--beta-2-gamma-2 expressed in L(tk-) cell membranes | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors. |
| AID1798593 | Radioligand Binding Assay from Article 10.1016/j.bmc.2008.08.072: \\A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.\\ | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis. |
| AID1346489 | Rat GABAA receptor alpha5 subunit (GABAA receptors) | 1997 | The Journal of pharmacology and experimental therapeutics, Nov, Volume: 283, Issue:2
| [3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acidA receptors containing alpha-5 subunits. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |