pityriacitrin and Prostatic-Neoplasms

pityriacitrin has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pityriacitrin and Prostatic-Neoplasms

Article	Year
Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives. European journal of medicinal chemistry, 2011, Volume: 46, Issue:12 We report herein the chemical synthesis and biological evaluation of β-carboline alkaloid pityriacitrin and some of its new derivatives. Using tryptophan or 5-hydroxytryptophan and 5-substituted indole-3-glyoxals as the starting materials, pityriacitrin and some of its derivatives were synthesized via the acid-catalyzed Pictet-Spengler reaction and fully characterized by (1)H and (13)C NMR, mass spectroscopy and IR determinations. Biological studies revealed that pityriacitrin has a weak antiproliferative activity against a panel of breast and prostate cancer cell lines, whereas some of its derivatives exhibited stronger and potent activity, which was associated with induction of both cell apoptosis and necrosis. Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indole Alkaloids; Malassezia; Male; Prostatic Neoplasms	2011

Article

Year

Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.

European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

We report herein the chemical synthesis and biological evaluation of β-carboline alkaloid pityriacitrin and some of its new derivatives. Using tryptophan or 5-hydroxytryptophan and 5-substituted indole-3-glyoxals as the starting materials, pityriacitrin and some of its derivatives were synthesized via the acid-catalyzed Pictet-Spengler reaction and fully characterized by (1)H and (13)C NMR, mass spectroscopy and IR determinations. Biological studies revealed that pityriacitrin has a weak antiproliferative activity against a panel of breast and prostate cancer cell lines, whereas some of its derivatives exhibited stronger and potent activity, which was associated with induction of both cell apoptosis and necrosis.

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indole Alkaloids; Malassezia; Male; Prostatic Neoplasms

2011