| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID266255 | Inhibition of p53-mediated increase in p21/WAF1 level at 30 nM | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID580132 | Reduction of paclitaxel-induced p21 expression in human IGROV1 cells at 5 uM after 24 hrs by Western blot analysis | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. |
| AID266253 | Protection against axotomy-induced RGC apoptosis in Wistar rat intravitreally injected with 6 uM | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID255408 | Concentration for 95% confidence interval (CI) in dexamethasone-induced mice thymocytes; range 1.45-2.80 uM | 2005 | Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
| Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. |
| AID266250 | Inhibition of etoposide-induced death of mouse E15.5 cortical neurones | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID266252 | Protection against axotomy-induced RGC apoptosis in Wistar rat intravitreally injected with 0.06 uM | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID580130 | Antiproliferative activity against human IGROV1 cells after 72 hrs by cell counter | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. |
| AID255646 | Concentration required to inhibit dexamethasone-induced death of mice thymocytes | 2005 | Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
| Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. |
| AID266251 | Inhibition of p53-mediated increase in p21/WAF1 level at 300 nM | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID266254 | Toxicity against mouse E15.5 cortical neurones at 10 uM | 2006 | Journal of medicinal chemistry, Jun-15, Volume: 49, Issue:12
| Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. |
| AID580133 | Reduction of paclitaxel-induced p21 expression in human IGROV1 cells at 0.3 uM after 24 hrs by Western blot analysis | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. |
| AID580131 | Reduction of paclitaxel-induced p21 expression in human IGROV1 cells at 0.12 uM after 24 hrs by Western blot analysis | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. |
| AID256221 | Average percent survival of C57Bl/6 mice thymocytes from Dexamethasone (5 uM) induced apoptosis at 5 uM | 2005 | Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
| Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. |
| AID580134 | Reduction of paclitaxel-induced p21 expression in human IGROV1 cells at 10 uM after 24 hrs by Western blot analysis | 2011 | Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
| Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |