Compounds > n,n-bis(carboxymethyl)glutamic acid
Page last updated: 2024-11-07

n,n-bis(carboxymethyl)glutamic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n,n-bis(carboxymethyl)glutamic acid, also known as N,N-bis(carboxymethyl)-L-glutamic acid or bis(carboxymethyl)glutamate, is a synthetic amino acid that functions as a chelating agent. It has been studied for its potential use in various applications, including:
* **Metal chelation:** n,n-bis(carboxymethyl)glutamic acid is a powerful chelator of various metal ions, including calcium, iron, copper, and zinc. This property has led to its investigation as a potential therapeutic agent for metal overload diseases, such as hemochromatosis.
* **Bioavailability enhancement:** n,n-bis(carboxymethyl)glutamic acid can improve the bioavailability of certain drugs and nutrients by forming complexes with them, enhancing their absorption and reducing their degradation.
* **Antioxidant activity:** Studies have shown that n,n-bis(carboxymethyl)glutamic acid exhibits antioxidant properties, protecting cells against oxidative damage. This is attributed to its ability to scavenge free radicals and chelate metal ions that can catalyze oxidative reactions.
* **Other applications:** n,n-bis(carboxymethyl)glutamic acid has also been investigated for its potential use in cosmetics, food additives, and agricultural applications.

The synthesis of n,n-bis(carboxymethyl)glutamic acid typically involves the reaction of glutamic acid with chloroacetic acid in the presence of a base. The resulting product is then purified and characterized.

The importance of studying n,n-bis(carboxymethyl)glutamic acid lies in its potential therapeutic applications and its diverse properties. Further research is needed to fully understand its mechanisms of action, safety, and efficacy in different contexts.'

N,N-bis(carboxymethyl)glutamic acid: a biodegradable chelating agent for heavy metals [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID100909
SCHEMBL ID130992
MeSH IDM000614885

Synonyms (10)

Synonym
2-[bis(carboxymethyl)amino]pentanedioic acid
n,n-bis(carboxymethyl)glutamic acid
einecs 261-530-8
l-glutamic acid, n,n-bis(carboxymethyl)-
220253-76-9
SCHEMBL130992
2-[bis(carboxymethyl)amino]glutaric acid
FT-0775241
2-[bis(carboxymethyl) amino]pentanedioic acid
DTXSID70860638

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"Chelating agents can increase the bioavailability of heavy metals and enhance their enrichment in plants."( [Enhanced Phytoextraction of Cadmium Contaminated Soil by
He, H; He, YL; Li, PR; Xie, SQ; Yu, J; Zhou, K, 2020)		0.56

Dosage Studied

ExcerptRelevanceReference
" The preliminary, dynamic, equilibrium activation experiments and speciation analysis of Pb, Cd and Tl in contaminated red soils were used to select six chelates with relatively good activation performance from nine chelates, and the effects of dosage and pH on the heavy metals activation were studied systematically."( Comparative Activation Process of Pb, Cd and Tl Using Chelating Agents from Contaminated Red Soils.
Huang, X; Liu, G; Liu, L; Liu, Y; Luo, D; Mai, X; Wei, L; Wu, Q; Xiao, T; Yao, G, 2020)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-butanol
1-Butanol: A four carbon linear hydrocarbon that has a hydroxy group at position 1.. butan-1-ol : A primary alcohol that is butane in which a hydrogen of one of the methyl groups is substituted by a hydroxy group. It it produced in small amounts in humans by the gut microbes.		2.2110alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol		human metabolite;
mouse metabolite;
protic solvent
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		2.5820tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
glycine
[no description available]		3.4260alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
nickel
Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.		2.1110metal allergen;
nickel group element atom		epitope;
micronutrient
pentetic acid
Pentetic Acid: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.		2.2510pentacarboxylic acidcopper chelator
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.2110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.2510ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.8830cadmium molecular entity;
zinc group element atom
yttrium
Yttrium: An element of the rare earth family of metals. It has the atomic symbol Y, atomic number 39, and atomic weight 88.91. In conjunction with other rare earths, yttrium is used as a phosphor in television receivers and is a component of the yttrium-aluminum garnet (YAG) lasers.		2.2110d-block element atom;
rare earth metal atom;
scandium group element atom
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.5720glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
n,n'-ethylenediamine disuccinic acid
N,N'-ethylenediamine disuccinic acid: from Actinomycetes MG417-CF17; structure given in first source		2.2510
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		2.2510carbon group element atom;
elemental lead;
metal atom		neurotoxin
barium
Barium: An element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.		2.2110alkaline earth metal atom;
elemental barium
strontium
Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.		2.2110alkaline earth metal atom
thallium
Thallium: A heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.. thallium : A metallic element first identified and named from the brilliant green line in its flame spectrum (from Greek thetaalphalambdalambdaomicronsigma, a green shoot).		2.2510boron group element atom
ConditionIndicatedRelationship StrengthStudiesTrials