Compounds > n-methyl-2-pyridone
Page last updated: 2024-11-05

n-methyl-2-pyridone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-methyl-2-pyridone is a heterocyclic compound that has been studied for its potential applications in various fields. It has been investigated as a precursor for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. The compound is also known to exhibit biological activity, including antimicrobial and anti-inflammatory properties. Research into N-methyl-2-pyridone is driven by its potential for use in the development of novel therapeutics and materials. The compound has shown promising results in studies examining its effectiveness against various bacterial and fungal infections. Additionally, its anti-inflammatory properties have led to exploration of its potential in treating inflammatory conditions. The synthetic versatility of N-methyl-2-pyridone allows for its modification to generate a range of derivatives with tailored properties, further expanding its application in medicinal chemistry and materials science.'

N-methyl-2-pyridone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12755
CHEMBL ID12607
CHEBI ID194916
SCHEMBL ID17685
SCHEMBL ID9496826
MeSH IDM000614516

Synonyms (51)

Synonym
einecs 211-777-2
ai3-11540
1-methylpyridine-2-one
n-methylpyridone
nsc 9383
brn 0107805
94071-56-4
nsc-176168
nsc176168
AC-907/25014126
nsc-9383
1-methyl-1,2-dihydro-2-pyridinone
1-methyl-2-pyridinone
nsc9383
1-methyl-2(1h)-pyridinone
1-methyl-2-pyridone
1-methyl-2(1h)-pyridone
2(1h)-pyridinone, 1-methyl-
2(1h)-pyridone, 1-methyl-
694-85-9
n-methyl-2-pyridone
1-methylpyridin-1-ium-2-ol
inchi=1/c6h7no/c1-7-5-3-2-4-6(7)8/h2-5h,1h
1-methylpyridin-2(1h)-one
n-methyl-2-pyridone, >=99%
CHEMBL12607
M0412
1-methylpyridin-2-one
CHEBI:194916
A9192
AKOS006306699
ny6mvo4k7r ,
unii-ny6mvo4k7r
5-21-07-00109 (beilstein handbook reference)
FT-0632827
AKOS015891684
SCHEMBL17685
SCHEMBL9496826
DTXSID8061008
859803-97-7
1-methyl-2-oxopyridine
1-methyl-1h-pyridin-2-one
mfcd00006520
1-methyl-1,2-dihydropyridin-2-one
n-methylpyridinium oxide
F0001-1804
CS-0063949
DS-14672
EN300-122028
pyridinium,2-hydroxy-1-methyl-,inner salt
SY023863
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
pyridone
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID1144175Drug excretion in po dosed beagle dog urine assessed as metabolite formation treated with [14C]-labelled N-Methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride by radiochromatography1976Journal of medicinal chemistry, Jan, Volume: 19, Issue:1
Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.
AID1136154Induction of erythroid differentiation in DBA/2J mouse Friend erythroleukemia cells assessed as cell growth after 3 days relative to control1978Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells.
AID70691Concentration producing the maximum percentage of benzidine-positive cells after 6-days of continuous exposure in murine leukemia cells.1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones.
AID70688Percentage of benzidine-positive murine erythroleukemia cells on day 6.1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones.
AID1144179Retardation factor of the compound1976Journal of medicinal chemistry, Jan, Volume: 19, Issue:1
Improved delivery through biological membranes. 2. Distribution, excretion, and metabolism of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, a pro-drug of N-methylpyridinium-2-carbaldoxime chloride.
AID1136157Induction of erythroid differentiation in DBA/2J mouse Friend erythroleukemia cells assessed as cell growth after 6 days relative to control1978Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells.
AID1136153Induction of erythroid differentiation in DBA/2J mouse Friend erythroleukemia cells assessed as concentration required for maximum proportion of benzidine positive cells after 6 days1978Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells.
AID70689Cell growth was measured on day 3, after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL.1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones.
AID1136156Induction of erythroid differentiation in DBA/2J mouse Friend erythroleukemia cells assessed as hemoglobin level per 10'7 cells after 3 to 6 days relative to control1978Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells.
AID70690Cell growth was measured on day 6 after murine erythroleukemia cells were exposed at a cell concentration of 1*10e5 cells/mL.1981Journal of medicinal chemistry, Sep, Volume: 24, Issue:9
Induction of differentiation of leukemia cells in vitro by N-substituted amides, lactams, and 2-pyridones.
AID1136155Induction of erythroid differentiation in DBA/2J mouse Friend erythroleukemia cells assessed as benzidine positive cells after 6 days relative to control1978Journal of medicinal chemistry, Sep, Volume: 21, Issue:9
Pyridine derivatives as potent inducers of erythroid differentiation in Friend leukemia cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.54 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		1.9510sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
hydrogen cyanide
Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.. hydrogen cyanide : A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom		1.9510hydracid;
one-carbon compound		Escherichia coli metabolite;
human metabolite;
poison
acetanilide
acetanilide: a phenylacetamide; use ACETANILIDES for the plural group meaning of the singular term. N-phenylacetamide : A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a phenyl group.		1.9610acetamides;
anilide		analgesic
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		2.0710pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
n-methylacetamide
N-methylacetamide: RN given refers to parent cpd. N-methylacetamide : A monocarboxylic acid amide that is the N-methyl derivative of acetamide.		1.9610acetamides;
monocarboxylic acid amide		metabolite
caprolactam
Caprolactam: Cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. Can cause local irritation.. epsilon-caprolactam : A member of the class of caprolactams that is azepane substituted by an oxo group at position 2.		1.9610caprolactamshuman blood serum metabolite
2-hydroxypyridine
hydroxypyridine : Any member of the class of pyridines with at least one hydroxy substituent.. pyridin-2-ol : A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2.		2.3620monohydroxypyridineplant metabolite
n-methylbenzamide
N-methylbenzamide: RN given refers to parent cpd		1.9610
2-pyrrolidone
2-pyrrolidone: RN given refers to parent cpd. pyrrolidin-2-one : The simplest member of the class of pyrrolidin-2-ones, consisting of pyrrolidine in which the hydrogens at position 2 are replaced by an oxo group. The lactam arising by the formal intramolecular condensation of the amino and carboxy groups of gamma-aminobutyric acid (GABA).		1.9610pyrrolidin-2-onesmetabolite;
polar solvent
2-piperidone
2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2.		1.9610delta-lactam;
piperidones		EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
n-methylpyrrolidone
1-methylpyrrolidin-2-one: structure in first source. N-methylpyrrolidin-2-one : A member of the class of pyrrolidine-2-ones that is pyrrolidin-2-one in which the hydrogen attached to the nitrogen is replaced by a methyl group.		1.9610lactam;
N-alkylpyrrolidine;
pyrrolidin-2-ones		polar aprotic solvent
n-ethyl-2-pyrrolidone
N-ethyl-2-pyrrolidone: structure in first source		1.9610N-alkylpyrrolidine
dimethylacetamide
hallucinogen : Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.. N,N-dimethylacetamide : A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.		1.9610acetamides;
monocarboxylic acid amide		human metabolite
n-methylnicotinamide
N-methylnicotinamide: structure. N-methylnicotinamide : A pyridinecarboxamide that is nicotinamide in which one of the amide hydrogens is substituted by a methyl group.		1.9610pyridinecarboxamidemetabolite
1,3-dimethyluracil
1,3-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 1 and 3.		2.0710pyrimidonemetabolite
n-methylpyridine-2-carboxamide
N-methylpyridine-2-carboxamide: structure in first source		1.9610
pralidoxime chloride
[no description available]		1.9510organic chloride salt;
pyridinium salt		cholinergic drug;
cholinesterase reactivator
ConditionIndicatedRelationship StrengthStudiesTrials
Di Guglielmo Disease
[description not available]		02.3620
Experimental Leukemia
[description not available]		02.3620
Leukemia, Erythroblastic, Acute
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.		02.3620