Page last updated: 2024-12-08

mvt 101

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Description

MVT 101: peptide inhibitor [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID449521
CHEMBL ID48996
MeSH IDM0171624
PubMed CID78171629
MeSH IDM0171624

Synonyms (24)

Synonym
(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s,3s)-2-[[(2s,3r)-2-acetamido-3-hydroxy-butanoyl]amino]-3-methyl-pentanoyl]amino]hexyl]amino]hexanoyl]amino]-n-[(1s)-1-carbamoyl-4-guanidino-butyl]pentanediamide
acthrilenle[nch2]nleglnargnh2
l-argininamide, n-acetyl-l-threonyl-l-isoleucyl-l-norleucyl-y(ch2-nh)-l-norleucyl-l-glutaminyl
mvt-101
2AOG
ace-t-i-nle-r-nle-q-r
n-1465 ,
2AVQ
peptide inhibitor p2/nc
2AVM
bdbm13936
(2s)-n-[(1s)-4-carbamimidamido-1-carbamoylbutyl]-2-[(2s)-2-{[(2s)-2-[(2s,3s)-2-[(2s,3r)-2-acetamido-3-hydroxybutanamido]-3-methylpentanamido]hexyl]amino}hexanamido]pentanediamide
chembl48996 ,
n-{(2s)-2-[(n-acetyl-l-threonyl-l-isoleucyl)amino]hexyl}-l-norleucyl-l-glutaminyl-n~5~-[amino(iminio)methyl]-l-ornithinamide
2nc ,
(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s,3s)-2-[[(2s,3r)-2-acetamido-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]hexyl]amino]hexanoyl]amino]-n-[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
mfcd00133570
ac-thr-ile-nle-psi(ch2nh)nle-gln-arg-nh2
128657-47-6
CS-0107649
HY-P2054
AKOS040746138
125552-93-4
mvt 101
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (20)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Hiv-1 ProteaseHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain B, Hiv-1 ProteaseHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain A, Hiv-1 ProteaseHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain B, Hiv-1 ProteaseHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain A, Pol PolyproteinHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain B, Pol PolyproteinHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain A, Hiv-1 Protease (retropepsin)Human immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain B, Hiv-1 Protease (retropepsin)Human immunodeficiency virus type 1 (BH5 ISOLATE)Ki0.53000.53000.53000.5300AID977610
Chain A, HIV-1 proteaseHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain B, HIV-1 proteaseHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain A, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain B, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain A, Pol polyproteinHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki21.50000.00058.605841.0000AID977610
Chain B, Pol polyproteinHuman immunodeficiency virus type 1 (BH5 ISOLATE)Ki21.50000.00058.605841.0000AID977610
Chain A, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain B, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain A, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Chain B, Pol polyproteinHuman immunodeficiency virus 1Ki21.50000.00058.605841.0000AID977610
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (BRU ISOLATE)Ki12.11750.00000.08283.3000AID1797112
Protease Human immunodeficiency virus 1IC50 (µMol)1.90000.00010.22487.3200AID162056
Protease Human immunodeficiency virus 1Ki0.77810.00000.04433.1000AID160777; AID162713
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1797112Protease Inhibition Assay from Article 10.1016/j.jmb.2005.09.095: \\Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.\\2005Journal of molecular biology, Dec-09, Volume: 354, Issue:4
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2005Journal of molecular biology, Dec-09, Volume: 354, Issue:4
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
AID1811Experimentally measured binding affinity data derived from PDB2005Journal of molecular biology, Dec-09, Volume: 354, Issue:4
Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.
AID162713Binding affinity against HIV-1 aspartic proteinase was determined1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase.
AID160777Binding affinity to HIV-1 protease1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Three-dimensional pharmacophores from binding data.
AID162056Inhibition of HIV-1 Protease.1993Journal of medicinal chemistry, Jan-22, Volume: 36, Issue:2
Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2005The FEBS journal, Oct, Volume: 272, Issue:20
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
AID1811Experimentally measured binding affinity data derived from PDB2005The FEBS journal, Oct, Volume: 272, Issue:20
Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.56)18.7374
1990's12 (66.67)18.2507
2000's4 (22.22)29.6817
2010's1 (5.56)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]