Compounds > ethyl isonicotinate
Page last updated: 2024-11-05

ethyl isonicotinate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Ethyl isonicotinate is an ester of isonicotinic acid, which is a pyridine derivative. It is a colorless liquid with a pungent odor. The synthesis of ethyl isonicotinate can be achieved through various methods, including the esterification of isonicotinic acid with ethanol. The compound has been researched for its potential applications in medicinal chemistry and pharmaceutical development. Its importance lies in its ability to act as a building block for various bioactive compounds, including those exhibiting anti-inflammatory, antimicrobial, and antitumor properties. Research into ethyl isonicotinate is driven by its promising pharmacological activities and potential for the development of new therapeutic agents.'
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ethyl isonicotinate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15291
CHEMBL ID2251613
SCHEMBL ID24935
MeSH IDM0247756

Synonyms (51)

Synonym
HMS1754D18
ethyl isonicotinate
nsc-6854
.gamma.-pyridinecarboxylic acid ethyl ester
4-carboethoxypyridine
4-carbethoxypyridine
isonicotinic acid ethyl ester
wln: t6nj dvo2
ethyl 4-pyridinecarboxylate
nsc6854
isonicotinic acid, ethyl ester
4-pyridinecarboxylic acid, ethyl ester
1570-45-2
ethyl pyridine-4-carboxylate
brn 0122942
ai3-22194
einecs 216-379-2
gamma-pyridinecarboxylic acid ethyl ester
nsc 6854
ethyl isonicotinate, 98%
4-picolinic acid ethyl ester
AKOS001058465
I0137
A19456
5-22-02-00190 (beilstein handbook reference)
unii-ong7xti4bl
ong7xti4bl ,
ec 216-379-2
STL163966
BBL013187
FT-0625784
AM20050839
4-pyridinecarboxylic acid ethyl ester
SCHEMBL24935
CHEMBL2251613
DTXSID6061789
J-400966
ethyl isonicotinicate
CS-W020597
AC-22479
mfcd00006428
F0001-0560
ethyl isonicotinate, purum, >=99.0% (gc)
D70811
SY001919
4-ethoxycarbonylpyridine
AS-17585
ethylisonicotinate
BAA57045
EN300-176600
Z53833081
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1091224Thrips luring activity against female Frankliniella occidentalis (western flower thrips) assessed as induction of thrips to walk up odor-laden arm of Y-tube olfactometer by Y-tube olfactometer bioassay2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
4-Pyridyl carbonyl compounds as thrips lures: effectiveness for Western flower thrips in y-tube bioassays.
AID1091223Thrips luring activity against female New Zealand Thrips obscuratus (flower thrips) assessed as induction of thrips to walk up odor-laden arm of Y-tube olfactometer by Y-tube olfactometer bioassay2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
4-Pyridyl carbonyl compounds as thrips lures: effectiveness for Western flower thrips in y-tube bioassays.
AID1091222Thrips luring activity against female Frankliniella occidentalis (western flower thrips) assessed as trapping of thrips using compound treated yellow sticky traps relative to untreated control under commercial greenhouse2008Journal of agricultural and food chemistry, Aug-13, Volume: 56, Issue:15
4-Pyridyl carbonyl compounds as thrips lures: effectiveness for Western flower thrips in y-tube bioassays.
AID1090711Thrips luring activity against female Thrips tabaci (onion thrips) assessed as ratio of thrips in baited traps to unbaited traps during field trapping study2007Journal of agricultural and food chemistry, Jul-25, Volume: 55, Issue:15
4-pyridyl carbonyl and related compounds as thrips lures: effectiveness for onion thrips and new zealand flower thrips in field experiments.
AID1090713Thrips luring activity against female New Zealand Thrips obscuratus (flower thrips) assessed as ratio of thrips in baited traps to unbaited traps during field trapping study2007Journal of agricultural and food chemistry, Jul-25, Volume: 55, Issue:15
4-pyridyl carbonyl and related compounds as thrips lures: effectiveness for onion thrips and new zealand flower thrips in field experiments.
AID1090712Thrips luring activity against male New Zealand Thrips obscuratus (flower thrips) assessed as ratio of thrips in baited traps to unbaited traps during field trapping study2007Journal of agricultural and food chemistry, Jul-25, Volume: 55, Issue:15
4-pyridyl carbonyl and related compounds as thrips lures: effectiveness for onion thrips and new zealand flower thrips in field experiments.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.09 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.83 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzaldehyde
[no description available]		2.0310benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
methyl salicylate
methyl salicylate: used in over-the-counter liniments, ointments, lotions for relief of musculoskeletal aches and pains; has hemolytic effect on human & sheep erythrocytes; RN given refers to parent cpd; structure in Merck Index, 9th ed, #5990. methyl salicylate : A benzoate ester that is the methyl ester of salicylic acid.		2.0310benzoate ester;
methyl ester;
salicylates		flavouring agent;
insect attractant;
metabolite
phenylethyl alcohol
Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.. 2-phenylethanol : A primary alcohol that is ethanol substituted by a phenyl group at position 2.		2.0310benzenes;
primary alcohol		Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite
chloroform
Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.		2.0310chloromethanes;
one-carbon compound		carcinogenic agent;
central nervous system drug;
inhalation anaesthetic;
non-polar solvent;
refrigerant
linalool
linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.		2.1710monoterpenoid;
tertiary alcohol		antimicrobial agent;
fragrance;
plant metabolite;
volatile oil component
Ethyl 2-aminobenzoate
[no description available]		2.0310benzoate ester
salicylaldehyde
o-hydroxybenzaldehyde: structure in first source		2.0310hydroxybenzaldehydenematicide;
plant metabolite
methyl benzoate
methyl benzoate : A benzoate ester obtained by condensation of benzoic acid and methanol.		2.0310benzoate ester;
methyl ester		insect attractant;
metabolite
ethyl benzoate
ethyl benzoate : A benzoate ester obtained by condensation of benzoic acid and ethanol. It is a volatile oil component found in ripe kiwifruit, cranberry juice, and palm kernel oil.		2.0310benzoate ester;
ethyl ester		flavouring agent;
fragrance;
volatile oil component
4-cyanopyridine
4-cyanopyridine: spectroscopic probe for cytochrome P450 BM3		2.4420
ethyl salicylate
ethyl salicylate: causes erythema after topical application as an aerosol; found in blood		2.0310hydroxybenzoic acid
methyl anthranilate
methyl anthranilate : A benzoate ester that is the methyl ester of anthranilic acid.		2.0310benzoate esterflavouring agent;
metabolite
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.		2.0410diazine;
pyrimidines		Daphnia magna metabolite
4-hydroxymethylpyridine
4-hydroxymethylpyridine: structure in first source		2.0410
4-acetylpyridine
[no description available]		2.4420
n-methylaspartate
N-Methylaspartate: An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).. N-methyl-D-aspartic acid : An aspartic acid derivative having an N-methyl substituent and D-configuration.		1.9810amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
4-anisaldehyde
4-anisaldehyde: RN given refers to cpd with specified locants for methoxy moieties; structure in Merck, 9th ed, #696. p-methoxybenzaldehyde : A member of the class of benzaldehydes consisting of benzaldehyde itself carrying a methoxy substituent at position 4.		2.4420benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
selfotel
selfotel: a N-methyl-D-aspartate (NMDA) antagonist; used to treat stroke-induced impairment		1.9810non-proteinogenic alpha-amino acid
ethylnicotinate
[no description available]		2.4420aromatic carboxylic acid;
pyridines
beta-ionone
beta-ionone: stimulator of carotenogenesis; carotenoid inhibitor; intermediate in synthesis of Vit A; RN given refers to cpd without isomeric designation; structure. beta-ionone : An ionone that is but-3-en-2-one substituted by a 2,6,6-trimethylcyclohex-1-en-1-yl group at position 4.		2.0310iononeantioxidant;
fragrance
Jasmone
jasmone: RN refers to (Z)-isomer; structure given in first source		2.0310cyclic ketone
alpha-ionone
alpha-ionone: RN given refers to cpd without isomeric designation; structure		2.0310enone;
ionone;
methyl ketone
MeJA
[no description available]		2.0310Jasmonate derivatives
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610