Page last updated: 2024-10-06
Folate Biosynthesis
Proteins (11)
| Protein | Synonyms | Taxonomy |
|---|
| Dihydrofolate reductase | EC 1.5.1.3 | Escherichia coli K-12 |
| Dihydrofolate synthase/folylpolyglutamate synthase | DHFS / FPGS; EC 6.3.2.12; EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase; Folylpolyglutamate synthetase; Tetrahydrofolylpolyglutamate synthase | Escherichia coli K-12 |
| Aminodeoxychorismate lyase | EC 4.1.3.38; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCL | Escherichia coli K-12 |
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | EC 2.7.6.3; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK | Escherichia coli K-12 |
| Dihydropteroate synthase | DHPS; EC 2.5.1.15; Dihydropteroate pyrophosphorylase | Escherichia coli K-12 |
| GTP cyclohydrolase 1 | EC 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I | Escherichia coli K-12 |
| Dihydromonapterin reductase | H(2)-MPt reductase; EC 1.5.1.50; Dihydrofolate reductase; DHFR; 1.5.1.3 | Escherichia coli K-12 |
| Dihydroneopterin aldolase | DHNA; EC 4.1.2.25; 7,8-dihydroneopterin 2'-epimerase; 7,8-dihydroneopterin aldolase; 7,8-dihydroneopterin epimerase; 5.1.99.8; Dihydroneopterin epimerase | Escherichia coli K-12 |
| Dihydroneopterin triphosphate diphosphatase | EC 3.6.1.67; Dihydroneopterin triphosphate pyrophosphatase; dATP pyrophosphohydrolase | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 2 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase component | Escherichia coli K-12 |
| Aminodeoxychorismate synthase component 1 | ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 1 | Escherichia coli K-12 |
Compounds (14)
| Compound | Description |
|---|
| hydronium ion | |
| pyruvic acid | An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) |
| Orthophosphate | |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| glutamine | A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| 6-hydroxymethyl-7,8-dihydropterin | |
| chorismic acid | A cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS. |
| glycolaldehyde | structure |
| creolin | from refined coal tar oils |
| pyrophosphate | |