Page last updated: 2024-10-06

Folate Biosynthesis

Proteins (11)

ProteinSynonymsTaxonomy
Dihydrofolate reductaseEC 1.5.1.3Escherichia coli K-12
Dihydrofolate synthase/folylpolyglutamate synthaseDHFS / FPGS; EC 6.3.2.12; EC 6.3.2.17; Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase; Folylpolyglutamate synthetase; Tetrahydrofolylpolyglutamate synthaseEscherichia coli K-12
Aminodeoxychorismate lyaseEC 4.1.3.38; 4-amino-4-deoxychorismate lyase; ADC lyase; ADCLEscherichia coli K-12
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseEC 2.7.6.3; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPKEscherichia coli K-12
Dihydropteroate synthaseDHPS; EC 2.5.1.15; Dihydropteroate pyrophosphorylaseEscherichia coli K-12
GTP cyclohydrolase 1EC 3.5.4.16; GTP cyclohydrolase I; GTP-CH-IEscherichia coli K-12
Dihydromonapterin reductaseH(2)-MPt reductase; EC 1.5.1.50; Dihydrofolate reductase; DHFR; 1.5.1.3Escherichia coli K-12
Dihydroneopterin aldolaseDHNA; EC 4.1.2.25; 7,8-dihydroneopterin 2'-epimerase; 7,8-dihydroneopterin aldolase; 7,8-dihydroneopterin epimerase; 5.1.99.8; Dihydroneopterin epimeraseEscherichia coli K-12
Dihydroneopterin triphosphate diphosphataseEC 3.6.1.67; Dihydroneopterin triphosphate pyrophosphatase; dATP pyrophosphohydrolaseEscherichia coli K-12
Aminodeoxychorismate synthase component 2ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 2; Aminodeoxychorismate synthase, glutamine amidotransferase componentEscherichia coli K-12
Aminodeoxychorismate synthase component 1ADC synthase; ADCS; EC 2.6.1.85; 4-amino-4-deoxychorismate synthase component 1Escherichia coli K-12

Compounds (14)

CompoundDescription
hydronium ion
pyruvic acidAn intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Orthophosphate
glutamic acidA non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Adenosine TriphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
glutamineA non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
6-hydroxymethyl-7,8-dihydropterin
chorismic acidA cyclohexadiene carboxylic acid derived from SHIKIMIC ACID and a precursor for the biosynthesis of UBIQUINONE and the AROMATIC AMINO ACIDS.
glycolaldehydestructure
creolinfrom refined coal tar oils
pyrophosphate