D-galactonate catabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid. [GOC:ai, GOC:mah]

The D-galactonate catabolic process is a metabolic pathway involved in the breakdown of D-galactonate, a sugar acid, to produce pyruvate and glyceraldehyde 3-phosphate. This process is essential for the utilization of galactose, a common sugar found in dairy products and other foods, as an energy source.

The pathway begins with the conversion of D-galactonate to L-galactonate by the enzyme D-galactonate dehydratase. This enzyme catalyzes the removal of a molecule of water from D-galactonate, producing a double bond between the carbon atoms at positions 2 and 3.

L-galactonate is then oxidized to L-galactose by the enzyme L-galactonate dehydrogenase. This enzyme uses NAD+ as an electron acceptor, reducing it to NADH.

L-galactose is then converted to D-galactose by the enzyme galactose mutarotase. This enzyme catalyzes the interconversion of the alpha and beta anomers of galactose.

D-galactose is then phosphorylated by the enzyme galactokinase, producing galactose 1-phosphate. This reaction requires the input of ATP, which is hydrolyzed to ADP.

Galactose 1-phosphate is then converted to UDP-galactose by the enzyme UDP-galactose pyrophosphorylase. This reaction uses UTP as a substrate, producing pyrophosphate as a byproduct.

UDP-galactose is then converted to UDP-glucose by the enzyme UDP-galactose 4-epimerase. This enzyme catalyzes the epimerization of the hydroxyl group at position 4 of UDP-galactose, producing UDP-glucose.

UDP-glucose is then converted to glucose 1-phosphate by the enzyme glucose 1-phosphatase. This reaction releases UDP as a byproduct.

Glucose 1-phosphate is then converted to glucose 6-phosphate by the enzyme phosphoglucomutase. This reaction involves the transfer of a phosphate group from position 1 to position 6 of glucose.

Glucose 6-phosphate is then processed through glycolysis, a metabolic pathway that breaks down glucose into pyruvate and glyceraldehyde 3-phosphate.

The D-galactonate catabolic process plays an important role in carbohydrate metabolism. It allows the body to utilize galactose as an energy source, and it contributes to the overall metabolic homeostasis of the organism.'
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Proteins (2)

Compounds (1)