2,2'-biquinoline profile

2,2'-Biquinoline is a heterocyclic organic compound with the formula C18H12N2. It is a colorless crystalline solid that is soluble in organic solvents. 2,2'-Biquinoline is an important ligand in coordination chemistry and has been used to synthesize a variety of metal complexes. It has been studied for its potential applications in areas such as luminescence, catalysis, and medicine. 2,2'-Biquinoline is synthesized through a variety of methods, including the reaction of 2-chloroquinoline with 2-lithioquinoline. It is also prepared through a condensation reaction involving 2-aminoquinoline and quinoline-2-carbaldehyde. 2,2'-Biquinoline has been shown to have a number of biological activities, including anticancer and antibacterial properties. For example, it has been shown to inhibit the growth of human cancer cells. It is also used in organic synthesis as a catalyst for a variety of reactions, including the Diels-Alder reaction. Due to its versatile nature, 2,2'-Biquinoline has attracted significant research interest in various fields, including coordination chemistry, material science, and medicinal chemistry. It is being explored for its potential applications in areas such as luminescent materials, catalysts, and pharmaceuticals. The compound exhibits photophysical properties that make it a good candidate for fluorescent sensors and probes. Research involving 2,2'-Biquinoline focuses on its structural modification to create new ligands with tailored properties for various applications. '

2,2'-biquinoline: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	8412
SCHEMBL ID	170196
MeSH ID	M0378641

Synonym
cuproine
nsc-1533
2,2'-diquinolyl
cuproin
nsc1533
2,2'-biquinoline
119-91-5
2,2'-biquinolyl
OPREA1_035027
STK359616
2,2'-biquinoline, 98%
biquinoline
B0470
wptcsqbwluuydv-uhfffaoysa-
inchi=1/c18h12n2/c1-3-7-15-13(5-1)9-11-17(19-15)18-12-10-14-6-2-4-8-16(14)20-18/h1-12h
2-quinolin-2-ylquinoline
AKOS000678368
unii-6ro6ga6rp3
6ro6ga6rp3 ,
nsc 1533
einecs 204-357-5
FT-0609160
AM84351
SCHEMBL170196
DTXSID8059500
2,2'-quinolyl
CS-B1769
W-108493
sr-01000596937
SR-01000596937-1
mfcd00006740
2,2'-biquinoline, for spectrophotometric det. of cu, >=99.0%
2,2-biquinoline
2,2/'-biquinoline
Q3597981
2,2 inverted exclamation mark -biquinoline
SY038917
2,8'-biquinoline
2,2'-bichinoline
2,2'-diquinoline
AS-15430
HMS3749A07
YSWG803
EN300-7409399
2-(quinolin-2-yl)quinoline

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (26.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (20.00)	29.6817
2010's	7 (46.67)	24.3611
2020's	1 (6.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.03	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	2.15	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
dimethyl sulfide dimethyl sulfide: structure. dimethyl sulfide : A methyl sulfide in which the sulfur atom is substituted by two methyl groups. It is produced naturally by some marine algae.. methyl sulfide : Any aliphatic sulfide in which at least one of the organyl groups attached to the sulfur is a methyl group.	2.1	1	aliphatic sulfide	algal metabolite; bacterial xenobiotic metabolite; EC 3.5.1.4 (amidase) inhibitor; Escherichia coli metabolite; marine metabolite
1,10-phenanthroline 1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases	2.13	1	phenanthroline	EC 2.7.1.1 (hexokinase) inhibitor; EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
quinoline [no description available]	7.03	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines
diphenyl diphenyl: RN given refers to unlabeled cpd; structure	6.93	1	aromatic fungicide; benzenes; biphenyls	antifungal agrochemical; antimicrobial food preservative
isoquinoline [no description available]	7.03	1	azaarene; isoquinolines; mancude organic heterobicyclic parent; ortho-fused heteroarene
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.03	1	metal allergen; nickel group element atom; platinum group metal atom
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.77	3	elemental platinum; nickel group element atom; platinum group metal atom
rhenium Rhenium: A metal, atomic number 75, atomic weight 186.207, symbol Re.	2.52	2	manganese group element atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.63	2	iron group element atom; platinum group metal atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	7.43	2	copper group element atom; elemental silver	Escherichia coli metabolite
terbium Terbium: An element of the rare earth family of metals. It has the atomic symbol Tb, atomic number 65, and atomic weight 158.92.	2.13	1	f-block element atom; lanthanoid atom
iodine [no description available]	2.11	1	halide anion; monoatomic iodine	human metabolite
sparfloxacin [no description available]	2.11	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone
neocuproine neocuproine: Spectrophotometric determination of copper and ultramicro blood sugar determinations; structure; RN given refers to parent cpd. neocuproine : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9.	2.11	1	phenanthrolines	chelator; copper chelator
xanthoxyline xanthoxyline: isolated from Sebastiania schottiana (Euphorbiaceae); structure given in first source; also present in Xanthoxylum, Rutaceae, Artemisia and other plants	2.13	1	carboxylic ester
1,7-phenanthroline [no description available]	2.82	3	phenanthroline
bicinchoninic acid [no description available]	6.93	1
bathophenanthroline 4,7-diphenyl-1,10-phenanthroline : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two phenyl substituents at positions 4 and 7.	2.13	1	benzenes; phenanthrolines	chelator
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.11	1	oxygen hydride; oxygen radical; reactive oxygen species
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.6	1	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
tartaric acid tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.	2.11	1	tartaric acid	Escherichia coli metabolite
betadex beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	2.01	1	cyclodextrin
alpha-cyclodextrin alpha-cyclodextrin : A cycloamylose composed of six alpha-(1->4) linked D-glucopyranose units.	2.01	1	cyclodextrin
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.01	1	glycoside
methyl orange methyl orange: indictor of pH with strong acids & bases; also used as reagent to form ion pairs with, and thereby isolate, certain compounds from biological material; minor descriptor (75-86); on-line & INDEX MEDICUS search AZO COMPOUNDS (75-86); file maintained to Azo cpds	2.11	1

Condition	Relationship Strength	Studies
Bacterial Disease [description not available]	2.13	1
Fungal Diseases [description not available]	2.13	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.13	1
Mycoses Diseases caused by FUNGI.	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.48	2

2,2'-biquinoline

Description

Cross-References

Synonyms (45)

Research

Studies (15)

Market Indicators

Research Demand Index: 26.96

Study Types