Compounds > 1,3-dibromopropane
Page last updated: 2024-11-05

1,3-dibromopropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,3-Dibromopropane is an organic compound with the formula CH2BrCH2CH2Br. It is a colorless liquid with a pungent odor. It is used as a reagent in organic synthesis, particularly in the preparation of other organic compounds. 1,3-Dibromopropane is also used as a solvent, a fumigant, and a fire retardant. 1,3-Dibromopropane is a toxic and flammable compound. It is also a potential human carcinogen. It is important to handle this compound with care and to use appropriate personal protective equipment. 1,3-Dibromopropane is studied for its potential use in the synthesis of new drugs and materials. It is also studied for its environmental effects. It is important to understand the properties and effects of this compound in order to use it safely and responsibly.'

1,3-dibromopropane: see also record for dibromopropane [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8001
SCHEMBL ID2175
MeSH IDM0101875

Synonyms (64)

Synonym
1,3-dibromo-propane
nsc62663
nsc-62663
wln: e3e
trimethylene bromide
trimethylene dibromide
.omega.,.omega.'-dibromopropane
.alpha.,.gamma.-dibromopropane
ccris 6711
einecs 203-690-3
nsc 62663
hsdb 7408
ai3-28592
alpha,gamma-dibromopropane
1,3-dibromopropane
propane, 1,3-dibromo-
109-64-8
inchi=1/c3h6br2/c4-2-1-3-5/h1-3h
1,3-dibromopropane, reagentplus(r), 99%
D0202
AKOS000118758
A802067
yqr3048ix9 ,
unii-yqr3048ix9
NCGC00260264-01
dtxsid1021902 ,
tox21_202716
dtxcid701902
cas-109-64-8
BBL011375
c3h6br2
STL146473
286013-06-7
1,3-dibromopropane-2-13c
FT-0606630
trimethylene bromide [mi]
dibromopropane, 1,3-
1,3-dibromopropane [hsdb]
SCHEMBL2175
J-503888
br(ch2)3br
1,3-dibromo- propane
1,3- dibromopropane
1,3-di-bromopropane
1,3dibromopropane
1,3-dibrompropane
1, 3-dibromopropane
1,3 dibromopropane
1,3-dibromopropan
1,3-dibromo -propane
1,3-dibromo propane
1.3-dibromopropane
dibromo-1,3 propane
ch2brch2ch2br
CS-W020641
J-802013
F0001-0197
mfcd00000255
1,3-dibromopropane, vetec(tm) reagent grade, 97.5%
Q408240
AMY25527
D77913
BP-31190
EN300-19283

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Newborn rat studies were conducted with oral administration of 1,3-dibromopropane (DBP) and 1,1,2,2-tetrabromoethane (TBE) from postnatal Days 4 to 21 to allow comparison of NOAELs and unequivocally toxic levels with those from 28-day young rat studies starting at 5-6 weeks of age."( Susceptibility of newborn rats to hepatotoxicity of 1,3-dibromopropane and 1,1,2,2-tetrabromoethane, compared with young rats.
Ema, M; Fukuda, N; Hasegawa, R; Hirata-Koizumi, M; Ito, Y; Kamata, E; Kusuoka, O; Nishimura, N; Ogata, H; Wada, H, 2005)		0.82
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency24.70920.000714.592883.7951AID1259369; AID1259392
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (21.43)18.7374
1990's2 (14.29)18.2507
2000's4 (28.57)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 44.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index44.88 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index63.62 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (44.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethylene dichloride
ethylene dichloride: RN given refers to 1,2-isomer; structure given in first source. 1,2-dichloroethane : A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.		2.110chloroethaneshepatotoxic agent;
mutagen;
non-polar solvent
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		1.9610halide anion;
monoatomic bromine
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		1.981017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
serine
Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.		1.9810L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		1.9810amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
propane
Propane: A three carbon alkane with the formula H3CCH2CH3.		4.01140alkane;
gas molecular entity		food propellant
1,2-dibromopropane
1,2-dibromopropane: structure given in first source		2.110
propylene dichloride
propylene dichloride: Russian drug; structure. 1,2-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.		2.110chloroalkane;
volatile organic compound
1,2,3-trichloropropane
[no description available]		2.110organochlorine compound
1-bromopropane
1-bromopropane: used as a solvent. 1-bromopropane : A bromoalkane that is propane carrying a bromo substituent at position 1.		2.110bromoalkane;
bromohydrocarbon		neurotoxin;
solvent
pentane
Pentanes: Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.. pentane : A straight chain alkane consisting of 5 carbon atoms.		1.9810alkane;
volatile organic compound		non-polar solvent;
refrigerant
tetrahydrofuran
oxolane : A cyclic ether that is butane in which one hydrogen from each methyl group is substituted by an oxygen.		1.9810cyclic ether;
oxolanes;
saturated organic heteromonocyclic parent;
volatile organic compound		polar aprotic solvent
1-bromohexane
[no description available]		2.110
hydrazine
diamine : Any polyamine that contains two amino groups.		2.0510azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		2.110thiazolidine
1,6-dichlorohexane
[no description available]		2.110
1-chlorohexadecane
[no description available]		2.110
dibromopropane
dibromopropane: see also record for 1,3-dibromopropane		7.3620
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9810cysteiniumfundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Liver Injury, Drug-Induced
[description not available]		02.0310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0310
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.0310
Glycosuria
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).		01.9610