Page last updated: 2024-12-05

1,6-dichlorohexane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1,6-Dichlorohexane: A Building Block for Polymers and More

1,6-Dichlorohexane is a colorless liquid with a faint, sweet odor. Its chemical formula is Cl(CH2)6Cl, meaning it has two chlorine atoms attached to the ends of a six-carbon chain (hexane).

**Why is it important for research?**

1,6-Dichlorohexane is a valuable starting material in the synthesis of various organic compounds, including polymers, pharmaceuticals, and other chemicals. Here's why:

* **Polymer Synthesis:** Its two reactive chlorine atoms allow for easy coupling with other molecules, making it an ideal building block for creating polymers. This includes:
* **Polyamides (Nylons):** 1,6-Dichlorohexane can be used to create monomers like adipic acid, which is a crucial component of nylon, a strong and versatile material.
* **Polyesters:** Similar to nylon, 1,6-Dichlorohexane can be incorporated into monomers for polyester production, known for their flexibility and durability.
* **Pharmaceutical Applications:** Its reactivity also makes it useful in the synthesis of certain pharmaceuticals, as it can be used to introduce chlorine atoms into drug molecules, influencing their properties and potential applications.
* **Industrial Chemistry:** It plays a role in the production of other chemicals like plasticizers, which are used to increase the flexibility of plastics, and solvents, which are used to dissolve other substances.

**Research Focus:**

Research on 1,6-Dichlorohexane focuses on:

* **Improving its synthesis:** Exploring more efficient and sustainable methods for producing 1,6-Dichlorohexane.
* **Developing new applications:** Exploring its potential in new areas like biocompatible materials and advanced polymers.
* **Evaluating its environmental impact:** Studying its toxicity and degradation in the environment to ensure safe and responsible use.

**Overall, 1,6-Dichlorohexane is a versatile chemical that plays a significant role in various industries and research fields, showcasing its importance in modern science and technology.**

Cross-References

ID SourceID
PubMed CID16551
CHEMBL ID3183456
SCHEMBL ID22252
MeSH IDM0507921

Synonyms (38)

Synonym
hexane, 1,6-dichloro-
nsc-60700
2163-00-0
nsc60700
hexane,6-dichloro-
1,6-dichlorohexane ,
1,6-dichlorohexane, 98%
D0372
hexamethylene chloride
hexamethylene dichloride
ovismsjckcdopu-uhfffaoysa-
inchi=1/c6h12cl2/c7-5-3-1-2-4-6-8/h1-6h2
AKOS009156467
einecs 218-491-7
nsc 60700
ec 218-491-7
yk75382q85 ,
unii-yk75382q85
dtxsid9044409 ,
tox21_302121
NCGC00255999-01
dtxcid7024409
cas-2163-00-0
A815545
FT-0600492
AM84762
SCHEMBL22252
1,6-dichloro hexane
1,6-dichlorohexane(hexamethylene dichloride)
CHEMBL3183456
mfcd00001020
J-014192
E76677
CS-W016259
AS-14371
Q161559
1,6-dichloro-hexane
EN300-58846
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.77610.001024.504861.6448AID743215
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's5 (62.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.65 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]