| Protein | Synonyms | Taxonomy |
|---|
| Prostaglandin reductase 2 | PRG-2; EC 1.3.1.48; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1 | Homo sapiens (human) |
| Fatty-acid amide hydrolase 1 | EC 3.5.1.99; Anandamide amidohydrolase 1; Fatty acid ester hydrolase; 3.1.1.-; Oleamide hydrolase 1 | Homo sapiens (human) |
| Prostaglandin E synthase | EC 5.3.99.3; Glutathione peroxidase PTGES; 1.11.1.-; Glutathione transferase PTGES; 2.5.1.18; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein | Homo sapiens (human) |
| Polyunsaturated fatty acid 5-lipoxygenase | EC 1.13.11.-; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase; 1.13.11.34 | Homo sapiens (human) |
| Arachidonate 5-lipoxygenase-activating protein | FLAP; MK-886-binding protein | Homo sapiens (human) |
| Prostaglandin G/H synthase 1 | EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1 | Homo sapiens (human) |
| Multidrug resistance-associated protein 1 | EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter | Homo sapiens (human) |
| Prostaglandin G/H synthase 2 | EC 1.14.99.1; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2 | Homo sapiens (human) |
| Aldo-keto reductase family 1 member C3 | EC 1.1.1.-; EC 1.1.1.210; EC 1.1.1.53; EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 1.1.1.357; Chlordecone reductase homolog HAKRb; Di | Homo sapiens (human) |
| MAP kinase-activated protein kinase 2 | MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2; EC 2.7.11.1 | Homo sapiens (human) |
| Hematopoietic prostaglandin D synthase | H-PGDS; EC 5.3.99.2; GST class-sigma; Glutathione S-transferase; 2.5.1.18; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase | Homo sapiens (human) |
| Leukotriene A-4 hydrolase | LTA-4 hydrolase; EC 3.3.2.6; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H; 3.4.11.4 | Homo sapiens (human) |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; 12-LOX; 1.13.11.31; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; 1.13.11.33; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; 1.13.11.-; Linoleate 13S-lipoxygenase; 1.13. | Homo sapiens (human) |
| Carbonyl reductase [NADPH] 1 | EC 1.1.1.184; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 1.1.1.196; 1.1.1.197; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; PG-9-KR; Prostaglandin-E(2) 9-reductase; 1.1.1.189; Short chain | Homo sapiens (human) |
| Thromboxane-A synthase | TXA synthase; TXS; EC 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152 | Homo sapiens (human) |
| Bifunctional epoxide hydrolase 2 | | Homo sapiens (human) |
| Serum paraoxonase/lactonase 3 | EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 | Homo sapiens (human) |
| Dipeptidase 1 | EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP | Homo sapiens (human) |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | 15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase B; 15-LOX-B; 1.13.11.33; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb; 1.13.11.- | Homo sapiens (human) |
| Serum paraoxonase/arylesterase 1 | PON 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1 | Homo sapiens (human) |
| Fatty-acid amide hydrolase 2 | EC 3.5.1.99; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2 | Homo sapiens (human) |
| Dipeptidase 2 | EC 3.4.13.19 | Homo sapiens (human) |
| Dipeptidase 3 | EC 3.4.13.19 | Homo sapiens (human) |
| Arachidonate 12-lipoxygenase, 12R-type | 12R-LOX; 12R-lipoxygenase; EC 1.13.11.-; Epidermis-type lipoxygenase 12 | Homo sapiens (human) |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 15-PGDH; EC 1.1.1.141; Prostaglandin dehydrogenase 1; Short chain dehydrogenase/reductase family 36C member 1 | Homo sapiens (human) |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | EC 1.13.11.-; Arachidonate (12S)-lipoxygenase; 12S-LOX; 12S-lipoxygenase; 1.13.11.31; Arachidonate (15S)-lipoxygenase; 1.13.11.33; Linoleate (13S)-lipoxygenase; Lipoxin synthase 12-LO; 3.3.2.-; Platelet-type lipoxygenase 12 | Homo sapiens (human) |
| Cytosolic phospholipase A2 | cPLA2; Phospholipase A2 group IVA | Homo sapiens (human) |
| Leukotriene C4 synthase | LTC4 synthase; EC 4.4.1.20; Glutathione S-transferase LTC4; 2.5.1.-; Leukotriene-C(4) synthase; Leukotriene-C4 synthase | Homo sapiens (human) |
| Acyl-CoA wax alcohol acyltransferase 1 | EC 2.3.1.75; Diacylglycerol O-acyltransferase 2-like protein 3; Diacylglycerol acyltransferase 2; Long-chain-alcohol O-fatty-acyltransferase 1 | Homo sapiens (human) |
| Glutathione hydrolase 1 proenzyme | EC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Prostaglandin-H2 D-isomerase | EC 5.3.99.2; Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; L-PGDS; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2 | Homo sapiens (human) |
| Prostaglandin reductase 1 | PRG-1; 15-oxoprostaglandin 13-reductase; 1.3.1.48; Dithiolethione-inducible gene 1 protein; D3T-inducible gene 1 protein; DIG-1; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; 1.3.1.74 | Homo sapiens (human) |
| Serum paraoxonase/arylesterase 2 | PON 2; EC 3.1.1.2; EC 3.1.1.81; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2 | Homo sapiens (human) |
| Prostamide/prostaglandin F synthase | Prostamide/PG F synthase; Prostamide/PGF synthase; EC 1.11.1.20; Peroxiredoxin-like 2B; Protein FAM213B | Homo sapiens (human) |
| Glutathione hydrolase 5 proenzyme | EC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14 | Homo sapiens (human) |
| Hydroperoxide isomerase ALOXE3 | Epidermis-type lipoxygenase 3; Epidermal LOX-3; e-LOX-3; eLOX-3; Hydroperoxy dehydratase ALOXE3; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152; Hydroperoxy icosatetraenoate isomerase; 5.4.4.7 | Homo sapiens (human) |
| Compound | Description |
|---|
| hydronium ion | |
| Glutathione | A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. |
| NADH | |
| Calcium | A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| Glutathione Disulfide | A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized. |
| dinoprostone | The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa. |
| dinoprost | A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. |
| epoprostenol | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| Magnesium | A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| salicylates | The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis. |
| malondialdehyde | The dialdehyde of malonic acid. |
| nad | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| NADP | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| prostaglandin h2 | A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins. |
| n(1)-methylnicotinamide | RN given refers to parent cpd |
| leukotriene a4 | (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene b4 | The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene c4 | The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| thromboxane a2 | An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS). |
| 15-keto-5,8,11,13-eicosatetraenoic acid | RN given refers to (E,Z,Z,Z)-isomer; RN for cpd without isomeric designation not available 3/88 |
| 15-hydroxy-5,8,11,13-eicosatetraenoic acid | potent & selective inhibitor of platelet lipoxygenase; RN given refers to cpd without isomeric designation |
| 5-hydroxy-6,8,11,14-eicosatetraenoic acid | |
| 5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid | RN given refers to (S-(R*,R*-(E,E,Z,Z)))-isomer |
| arachidonic acid 5-hydroperoxide | 5-HPETE is used inconsistently in literature as syn for cpds with various tetraene locants; RN given refers to (6,8,11,14)-isomer; RN in CA Vol 91 Form Index for (E,Z,Z,Z)-isomer: 70968-82-0; RN for (5,8,11,13)-isomer: 71133-12-5; in Merck, arachidonic acid is the (5,8,11,14)-isomer |
| 12-oxoleukotriene B4 | structure given in first source |
| 20-carboxyleukotriene b4 | metabolite of leukotriene B4 |
| leukotriene d4 | One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| leukotriene e4 | A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990) |
| prostaglandin a2 | RN given refers to (5Z,13E,15S)-isomer |
| prostaglandin b2 | RN given refers to (5Z,13E,15S)-isomer |
| prostaglandin g2 | |
| 9-deoxy-delta-9-prostaglandin d2 | has potent antineoplastic & weak smooth muscle contracting activities; structure given in first source |
| 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin d2 | PGD2 metabolite in human plasma |
| Dinoprost | A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. |
| 6-ketoprostaglandin f1 alpha | The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue. |
| 11-dehydro-thromboxane b2 | structure given in first source |
| arachidonic acid omega-9 hydroperoxide | |
| 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (s)-(e,z,z,z)-isomer | |
| anandamide | |
| thromboxane b2 | A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin). |
| 12-hydroxy-5,8,10-heptadecatrienoic acid | metabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation |
| 12-hydroxy-5,8,10,14-eicosatetraenoic acid | A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51) |
| 20-hydroxy-5,8,11,14-eicosatetraenoic acid | stimulator of renal sodium, potassium atpase; RN given is for the (all-Z) isomer |
| 5-oxo-6,8,11,14-eicosatetraenoic acid | RN given is for cpd without isomeric designation; an arachidonate metabolite which stimulates neutrophils to mobilize Ca and promotes PMN degranulation responses |
| 12-keto-5,8,11,13-eicosatetraenoic acid | |
| 15-hydroxy-5,8,11,13-eicosatetraenoic acid | potent & selective inhibitor of platelet lipoxygenase; RN given refers to cpd without isomeric designation |
| 5,6-epoxy-8,11,14-eicosatrienoic acid | RN given refers to cpd without isomeric designation |
| 8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid | |
| 15-deoxy-delta(12,14)-prostaglandin j2 | 15-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions |
| glutamate | |
| adenosine triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| 18-carboxy-19,20-dinorleukotriene B4 | structure given in first source |
| 20-aldehyde leukotriene B4 | |
| ethanolamine | A viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases. |
| 5-hydroxy-6,8,11,14-eicosatetraenoic acid | |
| 19-hydroxy-5,8,11,14-eicosatetraenoic acid | potent stimulator of renal sodium, potassium atpase; RN given is for the (all-Z) isomer |
| Coenzyme A | |
| eoxin c4 | structure in first source |
| eoxin D4 | |
| prostaglandin d2 | The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects. |
| eoxin E4 | |
| creolin | from refined coal tar oils |