Page last updated: 2024-09-03

aj 76 and clozapine

aj 76 has been researched along with clozapine in 6 studies

Compound Research Comparison

Studies
(aj 76)
Trials
(aj 76)
Recent Studies (post-2010)
(aj 76)
Studies
(clozapine)
Trials
(clozapine)
Recent Studies (post-2010) (clozapine)
37029,6917473,148

Protein Interaction Comparison

ProteinTaxonomyaj 76 (IC50)clozapine (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)0.14
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.6
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.032
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.47
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.476
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.045
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.1233
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.1534
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.15
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.031
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.013
Alpha-2A adrenergic receptorHomo sapiens (human)0.09
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)0.14
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.1534
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.0096
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)2
D(2) dopamine receptorHomo sapiens (human)0.2044
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0886
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0567
Alpha-2B adrenergic receptorHomo sapiens (human)0.023
Alpha-2C adrenergic receptorHomo sapiens (human)0.0079
DRattus norvegicus (Norway rat)1.066
D(3) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.2695
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)3.5772
D(2) dopamine receptorBos taurus (cattle)1.804
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.078
D(1A) dopamine receptorHomo sapiens (human)0.107
D(4) dopamine receptorHomo sapiens (human)0.0796
Adenylate cyclase type 3Rattus norvegicus (Norway rat)0.14
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)3.5772
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0567
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.47
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)5.7544
Histamine H2 receptorHomo sapiens (human)3.61
Alpha-1D adrenergic receptorHomo sapiens (human)0.035
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.9312
Adenylate cyclase type 2Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 4Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0658
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.373
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.587
D(4) dopamine receptorRattus norvegicus (Norway rat)0.9312
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.587
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0338
Histamine H1 receptorRattus norvegicus (Norway rat)0.023
Sodium-dependent serotonin transporterHomo sapiens (human)0.546
5-hydroxytryptamine receptor 2C Mus musculus (house mouse)0.028
5-hydroxytryptamine receptor 2AMus musculus (house mouse)0.028
Histamine H1 receptorHomo sapiens (human)0.0049
D(3) dopamine receptorHomo sapiens (human)0.354
Adenylate cyclase type 8Rattus norvegicus (Norway rat)0.14
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.081
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0567
5-hydroxytryptamine receptor 6Homo sapiens (human)0.0171
D(2) dopamine receptorMus musculus (house mouse)0.29
D(2) dopamine receptorRattus norvegicus (Norway rat)0.6759
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.6
5-hydroxytryptamine receptor 2BMus musculus (house mouse)0.028
Adenylate cyclase type 6Rattus norvegicus (Norway rat)0.14
Adenylate cyclase type 5Rattus norvegicus (Norway rat)0.14
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4162
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.6
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.6
5-hydroxytryptamine receptor 1AMus musculus (house mouse)2
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)0.14
DBos taurus (cattle)4.09

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's2 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P1
Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P1
Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X1
Piercey, MF; Vanover, KE; Woolverton, WL1
Griffon, N; Pilon, C; Sautel, F; Schwartz, JC; Sokoloff, P1
Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD1

Other Studies

6 other study(ies) available for aj 76 and clozapine

ArticleYear
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
    European journal of pharmacology, 1992, Apr-10, Volume: 225, Issue:4

    Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection

1992
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
    Nature, 1990, Sep-13, Volume: 347, Issue:6289

    Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution

1990
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
    Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21

    Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water

2003
Evaluation of the reinforcing and discriminative stimulus effects of cocaine in combination with (+)-AJ76 or clozapine.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:2

    Topics: Animals; Clozapine; Cocaine; Discrimination Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Reinforcement, Psychology; Tetrahydronaphthalenes

1993
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
    Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:10

    Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA Replication; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Flupenthixol; Glioma; Haloperidol; Humans; Hybrid Cells; Naphthalenes; Neuroblastoma; Pertussis Toxin; Phenothiazines; Pimozide; Pyrrolidines; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Risperidone; Salicylamides; Second Messenger Systems; Sulpiride; Tetrahydronaphthalenes; Tumor Cells, Cultured; Virulence Factors, Bordetella

1996
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
    Pharmacological research, 2001, Volume: 43, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes

2001